Gradient induced particle motion in suspensions

Patent metadata

Field	Value
Publication number	US-11007500-B2
Application number	US-201815913649-A
Country	US
Kind code	B2
Filing date	Mar 6, 2018
Priority date	Mar 10, 2017
Publication date	May 18, 2021
Grant date	May 18, 2021

Abstract

Methods of inducing or controlling particle motion in suspensions and colloids are described. In one aspect, a method of inducing particle motion in a suspension comprises contacting the suspension with a gas phase to establish at least one interface between the gas phase and continuous phase of the suspension. One or more gases of the gas phase are transferred across the interface to provide a solute gradient in the continuous phase, the solute gradient inducing motion of the suspended particles.

First claim

The invention claimed is:

1. A method of inducing or affecting particle motion in a suspension comprising:
contacting the suspension with a gas phase to establish at least one interface between the gas phase and suspension continuous phase;
transferring one or more gases of the gas phase across the interface to provide a solute gradient in the continuous phase, the solute gradient inducing or affecting motion of the suspended particles.

2. The method of claim 1 , wherein the solute gradient induces the suspended particles to move toward the interface.

3. The method of claim 1 , wherein the solute gradient induces the suspended particles to move away from the interface.

4. The method of claim 1 , wherein the one or more gases are dissolved in the continuous phase.

5. The method of claim 4 , wherein the one or more gases react with the continuous phase to provide an ion concentration gradient.

6. The method of claim 1 , wherein the one or more gases interact with an additive in the continuous phase to provide the solute gradient.

7. The method of claim 1 , wherein the one or more gases are transferred across the interface out of the continuous phase.

8. The method of claim 1 , wherein the suspended particles are dispersed throughout the continuous phase prior to contact of the suspension with the gas phase.

9. The method of claim 1 , wherein the suspension is a colloid.

10. The method of claim 1 , wherein the continuous phase is water or aqueous-based.

11. The method of claim 1 , wherein the continuous phase is a gas.

12. The method of claim 1 , wherein the suspended particles exhibit surface charge.

13. The method of claim 1 , wherein the suspended particles are concentrated by the solute gradient.

14. The method of claim 13 further comprising isolating the suspended particles from the suspension.

15. The method of claim 1 , wherein a plurality of gases are transferred across the interface.

16. The method of claim 1 , wherein the suspended particles comprise biological species selected from the group consisting of bacteria, viruses, nucleic acids, proteins, lipids and mixtures thereof.

17. An analytical method comprising:
disposing a suspension in a chamber, the suspension comprising analyte particles suspended in a continuous phase;
contacting the suspension with a gas phase to establish at least one interface between the gas phase and continuous phase;
transferring one or more gases of the gas phase across the interface to provide a solute gradient in the continuous phase, the solute gradient concentrating the analyte particles in a region of the chamber; and
detecting the concentrated analyte particles and/or determining one or more properties of the concentrated analyte particles.

18. A method of inhibiting fouling of a surface in contact with a fluid comprising:
contacting the fluid with a gas phase to establish at least one gas-fluid interface;
transferring one or more gases of the gas phase across the interface to provide a solute gradient in the fluid, the solute gradient inducing particle motion in the fluid away from the surface.

19. The method of claim 18 , wherein the gas-fluid interface is adjacent to the surface, and the solute gradient repels particles from the surface.

20. The method of claim 18 , wherein the gas-fluid interface is spaced apart from the surface, and the solute gradient attracts particles, thereby directing particle motion away from the surface.

21. The method of claim 18 , wherein the surface is porous.

22. The method of claim 21 , wherein the surface is a filter or membrane.

23. A method of detecting a soluble gas comprising:
providing a suspension in a chamber, the suspension comprising particles suspended in a continuous phase;
contacting the suspension with a gas sample to establish at least one interface between the gas sample and the continuous phase; and
detecting particle motion in the continuous phase in response to a solute gradient produced by dissolution of one or more gases from the sample after crossing the interface.

Assignees

• Univ Princeton

Inventors

• Shardt Orest
• Shin Sangwoo
• Shim Suin
• Warren Patrick B
• Stone Howard A

Classifications

• G01N33/0004 Primary

  Gaseous mixtures, e.g. polluted air · CPC title

• G01N1/4005

  by transferring a selected component through a membrane · CPC title

• G01N1/4055

  by solubility techniques · CPC title

• B01D61/00

  Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor (separation of gases or vapours by diffusion B01D53/22) · CPC title

• B01D61/147

  Microfiltration · CPC title