Compositions and methods for immunooncology
US-2024417722-A1 · Dec 19, 2024 · US
Microbubble tether for diagnostic and therapeutic applications
US11007285B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11007285-B2 |
| Application number | US-202016935998-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 22, 2020 |
| Priority date | Nov 21, 2014 |
| Publication date | May 18, 2021 |
| Grant date | May 18, 2021 |
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- Title
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Abstract
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The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
First claim
Opening claim text (preview).
The invention claimed is: 1. An ultrasound-based treatment method, comprising: introducing an albumin microbubble composition into a patient, wherein the albumin microbubble composition comprises: an albumin shell, a therapeutic or diagnostic agent, and a cyanine 5 acid or cyanine 5-PEG linking the albumin microbubble and the therapeutic or diagnostic agent; and directing ultrasonic energy at an anatomic region of interest to cause cavitation of the albumin microbubbles at the anatomic region of interest. 2. The ultrasound-based treatment method of claim 1 , further comprising: visualizing the presence of albumin microbubbles at the anatomic region of interest based on fluorescence of the therapeutic or diagnostic agent. 3. The ultrasound-based treatment method of claim 1 , wherein the therapeutic or diagnostic agent comprises a small molecule drug or a nucleic acid structure. 4. The ultrasound-based treatment method of claim 1 , wherein the therapeutic or diagnostic agent preferentially binds to the albumin shell relative to free, native human serum albumin at a ratio greater than 2. 5. The ultrasound-based treatment method of claim 1 , wherein the therapeutic or diagnostic agent preferentially binds to the albumin shell relative to free, native human serum albumin at a ratio greater than 4.0.
Assignees
Inventors
Classifications
- A61K9/0009Primary
involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title
Proteins, e.g. albumin · CPC title
- A61K49/223Primary
Microbubbles, hollow microspheres, free gas bubbles, gas microspheres · CPC title
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Frequently asked questions
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- What does patent US11007285B2 cover?
- The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
- Who is the assignee on this patent?
- Gen Electric
- What technology area does this patent fall under?
- Primary CPC classification A61K9/0009. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 18 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).