Rationally developed african swine fever attenuated virus strain protects against challenge with parental virus georgia 2007 isolate
US-9808520-B1 · Nov 7, 2017 · US
Development of a novel live attenuated African Swine Fever vaccine based in the deletion of gene I177L
US11007263B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11007263-B2 |
| Application number | US-201916580058-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 24, 2019 |
| Priority date | Sep 24, 2019 |
| Publication date | May 18, 2021 |
| Grant date | May 18, 2021 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises the ASFV-GΔI1771 modified virus, a recombinant ASFV-G modified by deleting a portion of the I177L ORF rendering the I177L gene nonfunctional.
First claim
Opening claim text (preview).
What is claimed is: 1. A genetically modified virus, wherein the virus genome comprises a viral genome at least 95% identical to SEQ ID NO: 2. 2. The virus of claim 1 , wherein the virus genome comprises a viral genome at least 99% identical to SEQ ID NO: 2. 3. The virus of claim 1 , wherein the viral genome comprises SEQ ID NO:2. 4. A vaccine composition against African Swine Fever Virus (ASFV), comprising the genetically modified virus of claim 1 , wherein the ASFV is ASFV-Georgia 2007 isolate (ASFV-G). 5. A method for the protection of swine against ASFV-G, comprising administering to a swine a live attenuated vaccine comprising the genetically modified virus of claim 1 in an amount effective to protect said swine from clinical ASFV-G disease. 6. A recombinant ASFV mutant virus, comprising a synthetic mutation in the I177L open reading frame or in a regulatory element controlling the expression of the I177L protein, resulting in a non-functional genomic I177L gene, wherein the mutant ASFV comprises a genome at least 95% identical to SEQ ID NO: 2. 7. The recombinant virus of claim 6 , wherein the mutant ASFV comprises a genome at least 99% identical to SEQ ID NO: 2.
Assignees
Inventors
Classifications
Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein · CPC title
- C12N7/00Primary
Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00) · CPC title
- A61P31/20Primary
for DNA viruses · CPC title
avirulent or attenuated · CPC title
- A61K39/12Primary
Viral antigens · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US11007263B2 cover?
- Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises the ASFV-GΔI1771 modified virus, a recombinant ASFV-G modified by deleting a portion of the I177L ORF rendering the I177L gene…
- Who is the assignee on this patent?
- Us Agriculture
- What technology area does this patent fall under?
- Primary CPC classification C12N7/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 18 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).