Compositions and methods for the treatment of chronic pain

Patent metadata

Field	Value
Publication number	US-11000487-B2
Application number	US-201716473300-A
Country	US
Kind code	B2
Filing date	Apr 19, 2017
Priority date	Dec 26, 2016
Publication date	May 11, 2021
Grant date	May 11, 2021

Abstract

The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX, formula X, formula XI, formula XII, formula XIII, formula XIV and formula XV and the methods for the treatment of chronic pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic pain.

First claim

The invention claimed is:

1. A compound of Formula VI

and a pharmaceutically acceptable hydrate, solvate, enantiomer, and stereoisomer thereof, wherein RH independently represents
menthol, retinoic acid, vitamin A, retinol, retinal, isotretinoin, curcumin, tretinoin, α-carotene, β-carotene retinol, d2 ergosterol, ergocalciferol, 7-dehydrocholesterol, cholecalciferol, 25-hydroxycholecalciferol, calcitriol (1,25-dihydroxycholecalciferol), calcitroic acid, d4 dihydroergocalciferol, alfacalcidol, dihydrotachysterol, calcipotriol, tacalcitol, paricalcitol, tocopherol, naphthoquinone, phylloquinone, menaquinone, menadione, menadiol, thiamine, acefurtiamine, allithiamine, benfotiamine, fursultiamine, octotiamine, prosultiamine, sulbutiamine, riboflavin, niacin, nicotinamide, pantothenic acid, dexpanthenol, pantethine, pyridoxine, pyridoxal phosphate, pyridoxamine, pyritinol, biotin, folic acid, dihydrofolic acid, folinic acid, levomefolic acid, adenosylcobalamin, cyanocobalamin, hydroxocobalamin, methylcobalamin, choline, ascorbic acid, dehydroascorbic acid, 1-docosanol or

wherein, within the proviso —R 1 , R 2 , R 3 independently represents

2. The compound of claim 1 , selected from the group consisting of:

3. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

4. The pharmaceutical composition of claim 3 , wherein said pharmaceutical composition is formulated to treat a patient in need with an effective amount of said pharmaceutical composition by oral administration, delayed release or sustained release, transmucosal administration, syrup, topical administration, parenteral administration, injection, subdermal, administration, oral solution, rectal administration, buccal administration or transdermal administration.

5. The pharmaceutical composition of claim 4 , wherein said pharmaceutical composition is formulated for the treatment of chronic pain, surgery pain, wound pain, ulcer pain, neuropathic pain, central and peripheral nerve damage pain.

Assignees

• Cellix Bio Private Ltd

Inventors

• Kandula Mahesh

Classifications

• C07D295/088

  to an acyclic saturated chain · CPC title

• C07C2601/14

  The ring being saturated · CPC title

• C07C225/20

  having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton · CPC title

• C07C219/32

  having amino groups bound to carbon atoms of six-membered aromatic rings and esterified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton · CPC title

• C07C219/14

  having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring · CPC title