Test device and test method using the same

Patent metadata

Field	Value
Publication number	US-11000355-B2
Application number	US-201616061298-A
Country	US
Kind code	B2
Filing date	Dec 6, 2016
Priority date	Dec 11, 2015
Publication date	May 11, 2021
Grant date	May 11, 2021

Abstract

A test device is disclosed. The test device includes a supporter providing a seating surface for an experimental animal, and a chair formed on the supporter and configured to induce a drug inhalation posture in which a head of the experimental animal is directed downward. Thus, a mecca position may be induced by a simple operation of seating an unconscious experimental animal on the chair. As a result, nose-to-brain drug delivery may be performed.

First claim

What is claimed is:

1. A test device comprising:
a supporter providing a seating surface for an experimental animal; and
a chair formed on the supporter and configured to induce a drug inhalation posture in which a head of the experimental animal is directed downward,
wherein a drug is injected to a brain of the experimental animal through a nose of the experimental animal induced in the drug inhalation posture, and
wherein the supporter extends in a longitudinal direction and the chair is provided in plurality in the longitudinal direction.

2. The test device of claim 1 , wherein a warm pad is formed on the supporter, and the warm pad is configured to maintain a body temperature of the experimental animal.

3. The test device of claim 2 , wherein a bottom of the chair is opened, and the warm pad is exposed through the chair.

4. The test device of claim 1 , wherein the chair comprises: a belt connected to both sides of the chair and configured to fix the experimental animal.

5. The test device of claim 4 , wherein the chair surrounds a left side, a right side and a back side of the experimental animal, and the belt surrounds and fixes a front side of the experimental animal.

6. The test device of claim 1 , wherein the supporter is configured to rotate on an axis parallel to the longitudinal direction.

7. The test device of claim 1 , further comprising: holders disposed at both sides of the supporter to support the supporter, wherein the supporter is vertically movable in a height direction of the holders.

8. A test method comprising:
inducing an experimental animal to be in a drug inhalation posture in which the experimental animal is seated on a supporter and is fixed in a state where a head thereof is directed downward; and
injecting a drug to a brain of the experimental animal through a nose of the experimental animal induced in the drug inhalation posture.

9. The test method of claim 8 , further comprising:
maintaining a body temperature of the experimental animal to which the drug is injected.

Assignees

• Iucf Hyu

Inventors

• Lee Sang-Kyung
• Ullah Irfan
• Chung Kunho
• Lee Sangah
• Kumar Priti

Classifications

• A61D7/00

  Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals (for reproduction or fertilisation A61D19/00 {; devices for implanting pellets, radon seeds or the like A61M37/0069}) · CPC title

• A61D3/00 Primary

  Arrangements for supporting or fettering animals for veterinary purposes · CPC title

• A61K49/0008

  Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure · CPC title

• A61D7/04

  Devices for anaesthetising animals by gases or vapours; Inhaling devices · CPC title