Aerosol generation and exposure system

Patent metadata

Field	Value
Publication number	US-11000065-B2
Application number	US-201716319814-A
Country	US
Kind code	B2
Filing date	Aug 2, 2017
Priority date	Aug 4, 2016
Publication date	May 11, 2021
Grant date	May 11, 2021

Abstract

A system is disclosed that includes a holder having a pressurized chamber and configured to secure an aerosol delivery device at least partially within the pressurized chamber. A test chamber is connected to the holder, the test chamber having an inlet allowing an aerosol from the aerosol delivery device to enter the test chamber.

First claim

What is claimed is:

1. A system comprising:
a pressurized gas source configured to generate a flow of gas;
a regulator configured to receive and regulate the flow of gas from the source, the regulator comprising a filter configured to filter the flow of gas from the gas source and a first pressure gauge configured to determine a pressure of the flow of gas from the source;
a multi-way solenoid valve configured to receive the flow of gas after passing through the regulator, the solenoid valve configured to selectively direct the flow of gas along a first pathway and a second pathway,
wherein the first pathway comprises:
a flowmeter configured to determine a flow rate of the flow of gas in the first pathway;
a second pressure gauge configured to determine a pressure of the flow of gas in the first pathway;
a multichannel manual valve configured to selectively direct gas from the second pathway to at least one of a plurality of holders;
at least one holder configured to receive the flow of gas from the multichannel manual valve through a channel linking the multichannel manual valve and the holder, the channel comprising an individual manual valve configured to control the flow of gas through the channel to the holder, the holder comprising a chamber pressurized by the flow of gas and an aerosol delivery device secured at least partially within the pressurized chamber; and
a test chamber connected to the holder, the test chamber comprising an inlet allowing an aerosol from the aerosol delivery device to enter the test chamber; and

wherein the second pathway comprises a different channel that leads to the test chamber without passing through the chamber pressurized by the flow of gas or the aerosol delivery device.

2. The system of claim 1 , wherein:
the flow of gas is configured to fill the pressurized chamber and cause the aerosol emitted from the aerosol delivery device to transfer from the pressurized chamber to the test chamber.

3. The system of claim 1 , further comprising the plurality of holders, the plurality of holders comprising the holder.

4. The system of claim 1 wherein the holder is configured to cause the aerosol delivery device to extend into the test chamber.

5. The system of claim 1 wherein the aerosol delivery device is an electronic cigarette.

6. A method comprising:
generating a flow of gas with a gas source;
receiving, regulating, and filtering the flow of gas with a regulator;
determining a pressure of the flow of gas from the gas source with a first pressure gauge;
receiving, with a multi-way solenoid valve, the flow of gas after the regulating, filtering, and pressure determination;
selectively directing, with the solenoid valve, the flow of gas along a first pathway and a second pathway,
wherein selectively directing the flow of gas along the first pathway comprises:
determining a flow rate of the flow of gas in the first pathway with a flowmeter:
determining a pressure of the flow of gas in the first pathway with a second pressure gauge;
selectively directing, with a multichannel manual valve, gas from the second pathway to at least one of a plurality of holders;
receiving, with at least one holder, the flow of gas from the multichannel manual valve through a channel linking the multichannel manual valve and the holder, the channel comprising an individual manual valve configured to control the flow of gas through the channel to the holder;
securing an aerosol delivery device at least partially within the holder, the holder comprising a pressurized chamber;
activating the aerosol delivery device to cause aerosol to be emitted from the aerosol delivery device; and
transferring the aerosol from the aerosol delivery device to a test chamber by at least pressurizing the pressurized chamber with the flow of gas; and

wherein selectively directing the flow of gas along the second pathway comprises directing the flow of gas to the test chamber in a different channel without passing through the chamber pressurized by the flow of gas or the aerosol delivery device.

7. The method of claim 6 , further comprising:
pressurizing the pressurized chamber to have a pressure greater than the test chamber, the pressure causing the aerosol to transfer from the aerosol delivery device to the test chamber through the aerosol delivery device.

8. The method of claim 6 wherein the pressurized chamber is pressurized to between 1 and 200 psi.

9. The system of claim 1 , wherein the different channel of the second pathway leads to the test chamber without passing through the flowmeter, the second pressure gauge, the multichannel manual valve, the individual manual valve, the pressurized chamber, or the aerosol delivery device.

10. The system of claim 9 , wherein the second pathway comprises a second flowmeter configured to determine a flow rate of the flow of gas in the different channel.

11. The system of claim 1 , wherein the solenoid valve is a four-way solenoid valve.

12. The system of claim 1 , wherein the test chamber comprises a platform configured to support a test subject inside the test chamber.

13. The system of claim 12 , wherein the test chamber further comprises a door for the test subject.

14. The system of claim 13 , wherein the test chamber further comprises an outlet configured to permit displaced gas to exit the test chamber.

15. The system of claim 1 , wherein the aerosol delivery device comprises a mouthpiece that protrudes into the test chamber.

16. The method of claim 6 , further comprising providing a platform configured to support a test subject inside the test chamber, and providing a door for the test subject.

17. The method of claim 16 , further comprising providing an outlet in the test chamber configured to permit displaced gas to exit the test chamber.

Assignees

• Charles R Drew Univ Of Medicine And Science
• Univ California

Inventors

• Friedman Theodore
• Shao Xuesi Max

Classifications

• A61D3/00

  Arrangements for supporting or fettering animals for veterinary purposes · CPC title

• A61M2016/0027

  pressure meter · CPC title

• A61D7/00

  Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals (for reproduction or fertilisation A61D19/00 {; devices for implanting pellets, radon seeds or the like A61M37/0069}) · CPC title

• A61M2209/02

  Equipment for testing the apparatus · CPC title

• A61M15/06

  Inhaling appliances shaped like cigars, cigarettes or pipes · CPC title