Macrocyclic polyphenols for universal coatings

Patent metadata

Field	Value
Publication number	US-10995225-B2
Application number	US-201716078493-A
Country	US
Kind code	B2
Filing date	Feb 22, 2017
Priority date	Feb 23, 2016
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

The disclosure provides for coating compositions comprising macrocycles and salts in aqueous buffer and the use of the coating composition to prevent absorption of small molecules into polymeric surfaces.

First claim

What is claimed is:

1. A coating composition comprising one or more salts selected from MgCl 2 , CaCl 2 and combination thereof, and one or more macrocycles in a bicine buffer, wherein the one or more macrocycles comprise the structure:

wherein,
x is an integer selected from 1, 2, 3, and 4, or a range including any two of the foregoing integers.

2. The coating composition of claim 1 , wherein the composition comprises between 0.5 mg/mL and 5 mg/mL of the one or more macrocycles.

3. The coating composition of claim 2 , wherein the composition comprises 1 mg/mL of the one or more macrocycles.

4. The coating composition of claim 1 , wherein the one or more macrocycles is dissolved in polar aprotic solvent.

5. The coating composition of claim 1 , wherein the one or more salts is used at a concentration of 0.1M to 3.0M.

6. The coating composition of claim 1 , wherein the pH of the aqueous buffer is from pH 7 to pH 10.

7. A method of coating one or more surfaces of a substrate comprising coating the substrate with the coating composition of claim 1 .

8. The method of claim 7 , wherein the one or more surfaces of the substrate is coated with the coating composition using dip coating or spin coating.

9. The method of claim 7 , wherein the one or more surfaces of the substrate comprises a polymer material.

10. The method of claim 9 , wherein the polymer material is a synthetic polymer material.

11. The method of claim 10 , wherein the synthetic polymer material is poly(dimethyl siloxane) (PDMS).

12. The method of claim 7 , wherein one of more surfaces that of a microfluidic or microphysiological system (MPS) are coated with the coating composition.

13. A microfluidic or MPS comprising one or more surfaces coated with the coating composition of claim 1 .

14. The microfluidic or MPS of claim 13 , wherein the microfluidic or MPS comprises PDMS.

Assignees

• Univ California

Inventors

• Healy Kevin
• Messersmith Phillip B
• Reese Willie Mae
• Burch Patrick

Classifications

• C07C217/94

  having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton · CPC title

• C07C245/20

  Diazonium compounds · CPC title

• C07C39/23

  polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings · CPC title

• C07C2603/54

  containing more than five condensed rings · CPC title

• C07C2603/52

  containing five condensed rings · CPC title