Temozolomide compounds, polymers prepared therefrom, and method of treating a disease

Patent metadata

Field	Value
Publication number	US-10995094-B2
Application number	US-202016735910-A
Country	US
Kind code	B2
Filing date	Jan 7, 2020
Priority date	Sep 22, 2016
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

A temozolomide compound according to formula (I)

is described, wherein R 1 , L 1 , and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

First claim

The invention claimed is:

1. A temozolomide compound of structure (I)

wherein
X is —O—;
L 1 is a divalent C 1-6 alkylene group;
n is 1; and
R 1 is an aldehyde group.

2. A temozolomide compound of structure (I)

wherein
X is —O—;
L 1 is a divalent C 1-6 alkylene group;
n is 1; and
R 1 is a ketone group
of the formula

wherein R 5 is a C 1-6 alkyl group.

Assignees

• Univ Massachusetts

Inventors

• Emrick Todd
• Skinner Matthew
• Ward Sarah M
• Saha Banishree

Classifications

• C08F220/365

  containing further carboxylic moieties · CPC title

• C07D487/04 Primary

  Ortho-condensed systems · CPC title

• A61K31/80

  Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795 · CPC title

• A61K47/60

  the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title

• A61K47/58

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin · CPC title