Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same

Patent metadata

Field	Value
Publication number	US-10995086-B2
Application number	US-201916359985-A
Country	US
Kind code	B2
Filing date	Mar 20, 2019
Priority date	Mar 21, 2018
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

The present technology provides triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

First claim

What is claimed is:

1. A compound of Formula X

or an isomer thereof, or a pharmaceutically acceptable salt thereof,
wherein
n is 1 or 2,
A is a heteroaryl group; said heteroaryl group has 1 to 5 heteroatom ring members chosen from O, N, and S, and said heteroaryl group is optionally substituted with a substituent chosen from C 1-3 alkyl, halogen, —R, —CH═CH—R, and —C≡C—R, and
R is benzyl; or a substituted or unsubstituted cyclic ring, optionally containing 1 to 5 heteroatom ring members chosen from O, N, and S, and the cyclic ring is aromatic or non-aromatic.

2. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein A is selected from thiazole, thiophene, pyrrole, pyrazole, imidazole, triazole, tetrazole, furan, oxazole, isoxazole, oxadiazole, thiadiazole, pyridine, pyrimidine, pyrazine, triazine, indole, azaindole, isoindole, azaisoindole, indazole, azaindazole, benzimidazole, azabenzimidazole, benzothiophene, azabenzothiophene, benzofuran, azabenzofuran, isobenzofuran, benzoisoxazole, benzooxazole, benzothiazole, benzothiadiazole, purine, and pyrazolo[1,5-a]pyrimidine.

3. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein A is selected from thiophene, thiazole, and benzothiophene.

4. A compound of Formula Y

or an isomer thereof, or a pharmaceutically acceptable salt thereof;
wherein
n is 1 or 2,
wherein A is a heteroaryl group selected from the group consisting of thiophene, thiazole, and benzothiophene,
wherein said heteroaryl group is optionally substituted with a substituent selected from the group consisting of C 1-3 alkyl, halogen, —R, —CH═CH—R, and —C≡C—R,
wherein said R is benzyl or a cyclic ring selected from the group consisting of benzene, pyridine, pyridin-2-one, tetrahydropyridine, pyrimidine, pyridazine, thiophene, imidazole, pyrazole, oxadiazol-5-one, 1,1-dioxidothiomorpholin-4-yl-methyl, benzodioxole, benzooxadiazole, benzothiadiazole, benzooxazole, benzooxazolone, benzothiazole, 1,3-dihydrobenzofuran, indazole, thiazolo[5,4-b]pyridine, pyrrolo[2,3-b]pyridine, pyrrolo[2,3-b]pyridin-2-one, triazolone[1,5-a]pyridine, 1,3-dihydroindol-2-one, 2,3-dihydroisoindol-1-one, triazolone, quinoline, isoquinoline, quinolin-2-one, 3,4-dihydroquinolin-2-one, 3,4-dihydroisoquinolin-1-one, 3,4-dihydroquinazolin-2-one, 3,4-dihydronaphthyridin-2-one, 3,4-dihydro-1,4-benzooxazine, 1,4-benzooxazin-3-one, 1,4-dihydro-3,1-benzooxazin-2-one, 1,4-benzothiazin-3-one, 3,4-dihydro-quinoxaline, 3,4-dihydro-2H-chromene, 1,2,3,4-tetrahydroquinoline, 5,6,7,8-tetrahydronaphthyridine, oxazolo[4,5-b]pyridin-2-one, imidazo[4,5-b]pyridine, pyrido[2,3-b][1,4]oxazine, pyrido[2,3-b][1,4]oxazin-2-one, pyrido[2,3-d][1,3]oxazin-2-one, pyrido[2,3-b][1,4]oxazin-3-one, pyrido[3,2-b][1,4]oxazine, and pyrido[3,2-b][1,4]oxazin-3-one, and
wherein said R is optionally substituted with one to three substituents selected from the group consisting of hydroxy, halogen, cyano, C 1-6 alkyl, C 3-6 cycloalkyl, benzyl, trifluoromethyl, hydroxy-C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkoxy, difluoromethoxy, trifluoro-C 1-6 alkoxy, 3,5-dimethoxybenzyloxy, (C 3-6 cycloalkyl)methoxy, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy-C 1-6 alkylamino, C 1-6 alkylsulfonylamino, C 1-6 alkylcarbonylamino, C 1-6 alkylthio, mono- or di-C 1-6 alkylaminocarbonyl, mono- or di-C 1-6 alkylaminosulfonyl, mono- or di-C 3-6 cycloalkylaminosulfonyl, pyrrolidinylsulfonyl, morpholinylsulfonyl, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfonyl-C 1-6 alkyl, C 1-6 alkoxycarbonyl, morpholinylcarbonyl, pyrrolidinyl, 5-oxopyrrolidinyl, piperidinyl, C 1-6 alkyl-piperidinyl, piperazinyl, acetylpiperazinyl, morpholinyl, morpholinyl-C 1-6 alkyl, tetrahydropyranyl, pyrazolyl, triazolyl, isoxazolyl, oxazolyl, oxadiazolyl, 1,2,4-oxadiazol-5(4H)-onyl, cyclopropyl-oxadiazolyl, and C 1-6 alkyl-oxadiazolyl.

5. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein n is 1.

6. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein A is thiophene.

7. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein said heteroaryl group is substituted with —R.

8. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein said R is a cyclic ring selected from the group consisting of benzene, pyridin-2-one, pyrazole, pyrrolo[2,3-b]pyridin-2-one, 1,3-dihydroindol-2-one, 2,3-dihydroisoindol-1-one, quinolin-2-one, 3,4-dihydroquinolin-2-one, 3,4-dihydroisoquinolin-1-one, 3,4-dihydroquinazolin-2-one, 1,4-benzooxazin-3-one, 1,4-dihydro-3,1-benzooxazin-2-one, 1,4-benzothiazin-3-one, pyrido[2,3-b][1,4]oxazin-2-one, and pyrido[3,2-b][1,4]oxazine.

9. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein said R is a cyclic ring selected from the group consisting of benzene, pyridin-2-one, pyrazole, 3,4-dihydroquinolin-2-one, 3,4-dihydroquinazolin-2-one, 1,4-benzooxazin-3-one, and 1,4-dihydro-3,1-benzooxazin-2-one.

10. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein said cyclic ring is substituted with halogen, C 1-6 alkyl or di-C 1-6 alkylaminocarbonyl.

11. The compound, or an isomer thereof, or a pharmaceutically acceptable salt thereof, of claim 1 ,
wherein n is 1,
wherein A is thiophene substituted with a cyclic ring selected from the group consisting of benzene, pyridin-2-one, pyrazole, 3,4-dihydroquinolin-2-one, 3,4-dihydroquinazolin-2-one, 1,4-benzooxazin-3-one, and 1,4-dihydro-3,1-benzooxazin-2-one, and
wherein said cyclic ring is substituted with halogen, C 1-6 alkyl or di-C 1-6 alkylaminocarbonyl.

12. A compound selected from:
2-[(2Z)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-4-[(5-bromothiophen-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;
2-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-4-[(5-bromothiophen-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride;
2-[(2Z)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-4-[5-(4-aminophenyl)thiophen-2-yl]methyl-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride;
2-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-4-(5-[3-(dimethylamino)phenyl]thiophen-2-ylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride;
2-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-4-(5-[4-(dimethylamino)phenyl]thiophen-2-ylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride;
2-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-4-(5-[3-(dimethylamino)-4-fluorophenyl]thiophen-2-ylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride;
N-4-[5-(1-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-ylmethyl)thiophen-2-yl]phenylmethansulfonamide hydrochloride;
3-[5-(1-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-ylmethyl)thiophen-2-yl]-N-methylbenzenesulfonamide hydrochloride;
4-[5-(1-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-ylmethyl)thiophen-2-yl]-N,N-dimethylbenzesulfonamide hydrochloride;
methyl 4-[5-(1-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-ylmethyl)thiophen-2-yl]benzoate hydrochloride;
methyl 3-[5-(1-[(2E)-2-(aminomethyl)-3-fluoroprop-2-en-1-yl]

Assignees

• Yuhan Corp

Inventors

• Han Tae Dong
• Tak Hee Jae
• Kim Eun Kyung
• Choi Su Bin
• Park Sol
• Kim Dong Hoon
• Kim So Young
• Choi Hyun Ho
• Kim Tae Wang
• Ju Mi Kyeong
• Ha Na Ry
• Lee Eui Chul

Classifications

• C07D409/04 Primary

  directly linked by a ring-member-to-ring-member bond · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• C07D409/06 Primary

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title