Compounds and compositions for inhibition of FASN
US-10472342-B2 · Nov 12, 2019 · US
Compounds and compositions for inhibition of FASN
US10995078B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10995078-B2 |
| Application number | US-202015929751-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 20, 2020 |
| Priority date | Mar 13, 2013 |
| Publication date | May 4, 2021 |
| Grant date | May 4, 2021 |
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- Title
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- Abstract
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- Assignees and inventors
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- First independent claim
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Abstract
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The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
First claim
Opening claim text (preview).
What is claimed is: 1. A compound selected from the group consisting of: NAME Structure 1-({4-[(4- phenylphenyl)carbonyl]piperazin-1- yl}carbonyl)cyclopropan-1-ol 2-hydroxy-2-methyl-1-{4-[(4- phenylphenyl)carbonyl]piperazin-1- yl}propan-1-one 2-hydroxy-1-{4-[(4- phenylphenyl)carbonyl]piperazin-1- yl}ethan-1-one 1-({4-[(4- phenylphenyl)carbonyl]piperazin-1- yl}carbonyl)cyclopentan-1-ol 3,3,3-trifluoro-2-hydroxy-2-methyl-1- {4[(4- phenylphenyl)carbonyl]piperazin-1- yl}propan-1-one 1-[(4-{[4-(3- methylphenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(4- methylphenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2-fluoro-3- methoxyphenyl)phenyl]carbonyl} piperazin-1-yl)carbonyl]cyclopropan-1- ol 1-[(4-{[4-(2-fluoro-4- methylphenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2-fluoro-4- methoxyphenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2-chloro-4- fluorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(3-chloro-4- fluorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(4-chloro-2- fluorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2,4- dichlorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(5-fluoro-2- methylphenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(3-fluoro-5- methylphenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2,3- dichlorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2,5- dichlorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(4-chloro-3- fluorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(2,5- difluorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan-1-ol 1-[(4-{[4-(3,4- difluorophenyl)phenyl]carbonyl}piperazin- 1-yl)carbonyl]cyclopropan
Assignees
Inventors
Classifications
Non-condensed pyrazines · CPC title
- C07D295/192Primary
from aromatic carboxylic acids · CPC title
linked by a carbon chain containing aromatic rings · CPC title
linked by a carbon chain containing aromatic rings · CPC title
linked by a carbon chain containing aromatic rings · CPC title
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Frequently asked questions
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- What does patent US10995078B2 cover?
- The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
- Who is the assignee on this patent?
- Forma Therapeutics Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D295/192. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 04 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 10 related publications on this page (citations in our corpus or others sharing the same primary CPC).