Devices and methods for repairing damage to a nerve

Patent metadata

Field	Value
Publication number	US-10994130-B2
Application number	US-201715697358-A
Country	US
Kind code	B2
Filing date	Sep 6, 2017
Priority date	Sep 6, 2016
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve.

First claim

What is claimed:

1. A device for repairing a nerve, comprising:
at least one flexible carrier layer, wherein the at least one flexible carrier layer is a biologic material; and
a metallic support member comprising a plurality of elongate strips and a plurality of micro-protrusions, the micro-protrusions extending from the elongate strips, wherein:
the metallic support member is at least partially integrated with the at least one flexible carrier layer,
the at least one flexible carrier layer is configured to cover at least a portion of the nerve,
the micro-protrusions are configured to attach to a superficial tissue of the nerve,
the elongate strips are not interconnected with one another within the at least one flexible carrier layer, and
wherein, for each of the elongate strips, a respective length extending along a longitudinal axis of the nerve is longer than a respective length extending along an axis perpendicular to the longitudinal axis of the nerve.

2. The device of claim 1 , wherein the micro-protrusions are sized and shaped to pierce the outer epineurium of the nerve.

3. The device of claim 2 , wherein the micro-protrusions are sized and shaped to not pierce a fascicle of the nerve.

4. The device of claim 1 , wherein the metallic support member is a superelastic alloy.

5. The device of claim 4 , wherein the superelastic alloy is of a composition that comprises nickel and titanium.

6. The device of claim 1 , wherein the biologic material is small intestine submucosa (SIS).

7. The device of claim 1 , wherein the at least one flexible carrier layer is a two-dimensional sheet.

8. The device of claim 7 , wherein the at least one flexible carrier layer is further configured to entubulate a repair site or sandwich a repair site.

9. The device of claim 8 , wherein the at least one flexible carrier layer comprises a wrapping portion for maintaining entubulation or sandwiching of the repair site.

10. The device of claim 8 , further comprising a fastener for maintaining entubulation or sandwiching of the repair site.

11. The device of claim 1 , wherein the micro-protrusions are bent out of plane with respect to the metallic support member in a direction of a first axis or a second axis of the metallic support member.

12. The device of claim 11 , wherein the micro-protrusions are bent out of plane with respect to the metallic support member in the direction of the first axis, and wherein the first axis substantially corresponds to the longitudinal axis of the nerve.

13. The device of claim 11 , wherein the micro-protrusions are bent out of plane with respect to the metallic support member in the direction of the second axis, wherein the first axis substantially corresponds to the longitudinal axis of the nerve, and wherein the second axis is substantially perpendicular to the first axis.

14. The device of claim 1 , wherein the micro-protrusions comprise a first group of micro-protrusions and a second group of micro-protrusions, and wherein the first and second groups of micro-protrusions are oriented in opposite directions.

15. The device of claim 14 , wherein the first and second groups of micro-protrusions are oriented to face each other.

16. The device of claim 1 , wherein each of the elongate strips comprises one or more projecting members.

17. The device of claim 1 , wherein the elongate strips are configured to not directly overlay a repair site.

18. The device of claim 1 , wherein at least one of the at least one flexible carrier layer or the metallic support member is configured for drug delivery or cell transplantation.

19. The device of claim 1 , wherein the micro-protrusions comprise at least one of micro-hooks or micro-needles.

20. The device of claim 1 , wherein at least one of the micro-protrusions comprises a barb.

21. The device of claim 1 , wherein at least one of the metallic support member or the micro-protrusions is configured for delivering electrical stimulation or recording electrical activity.

22. The device of claim 1 , further comprising wherein the at least one flexible carrier layer comprises a plurality of flexible carrier layers, each flexible carrier layer being a biologic material, wherein the metallic support member is sandwiched between the plurality of flexible carrier layers.

Assignees

• Biocircuit Tech Inc
• Univ Virginia Commonwealth

Inventors

• Clements Isaac Perry
• Willsie Andrew
• Ross James David
• Weidenbach Alex
• Isaacs Jonathan

Classifications

• A61B5/6882

  Anchoring means · CPC title

• A61N1/0558

  Anchoring or fixation means therefor · CPC title

• A61N1/0556 Primary

  Cuff electrodes · CPC title

• A61B5/6877

  Nerve · CPC title

• A61B5/24

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title