Drug delivery system with electromagnetic field generator

Patent metadata

Field	Value
Publication number	US-10994112-B2
Application number	US-201515039946-A
Country	US
Kind code	B2
Filing date	Feb 3, 2015
Priority date	Feb 5, 2014
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

A drug delivery device (100) includes a base (102) having a first region (104) with a drug delivery assembly (106) associated therewith. The drug delivery device also includes an antenna (112) disposed in the first region to radiate an electromagnetic field, the base defining a plane (114) and the antenna disposed in the plane of the base, and an electromagnetic field generator (116) selectively coupled to the antenna.

First claim

We claim:

1. A drug delivery device comprising:
a base having a first region and a second region adjacent to the first region;
a drug delivery assembly carried by the first region of the base for facilitating the delivery of a medicament to a patient during use of the drug delivery device, the drug delivery assembly including a plurality of needles disposed on the base;
an antenna disposed in the first region of the base and at least partially between at least two of the plurality of needles; and
an electromagnetic field generator carried by the base and in selective electrical communication with the antenna for selectively radiating an electromagnetic field from the antenna at least in a direction directly away from the base and into a tissue of the patient during use of the drug delivery device, thereby facilitating transfer of the medicament to the patient.

2. The drug delivery device according to claim 1 , wherein the needles are microneedles having a first end attached to the base and a second end spaced therefrom and the antenna disposed adjacent to the plurality of microneedles.

3. The drug delivery device according to claim 1 , wherein the drug delivery assembly comprises the medicament.

4. The drug delivery device of claim 2 , wherein the plurality of microneedles defines an array of microneedles, and the antenna is disposed in a pattern adjacent to the array of microneedles.

5. The drug delivery device of claim 4 , wherein the antenna is disposed in a serpentine pattern adjacent to the array of microneedles.

6. The drug delivery device of claim 2 , further comprising a layer of antimicrobial agent disposed on the outer surface of the microneedles.

7. The drug delivery device of claim 2 , wherein each microneedle has a longitudinal axis between the first and second ends, and the longitudinal axes of the microneedles are disposed at an angle to the plane of the base.

8. The drug delivery device of claim 7 , wherein the angle is between approximately 15 degrees and approximately 90 degrees.

9. The drug delivery device of claim 8 , wherein the angle is between approximately 15 degrees and approximately 45 degrees.

10. The drug delivery device of claim 9 , wherein the angle is 30 degrees.

11. The drug delivery device of claim 2 , wherein the each of the microneedles has a tear-drop cross-section in a plane parallel to the base.

12. The drug delivery device of claim 1 , further comprising a controller coupled to the electromagnetic field generator and having a first state wherein the antenna is decoupled from the electromagnetic field generator and a second state wherein the controller couples the electromagnetic field generator to the antenna.

13. A method of delivering a drug to a patient comprising:
applying a drug delivery device to a patient,
the delivery device comprising a base having a first region with a drug delivery assembly associated therewith, the drug delivery assembly including a plurality of needles carried by the base, and an antenna disposed in the first region and at least partially between at least two of the plurality of needles to radiate an electromagnetic field, the base defining a plane and the antenna disposed in the plane of the base;
emitting an electromagnetic field using the antenna, the electromagnetic field radiating directly away from the base and into a tissue of the patient adjacent to the drug delivery device, the electromagnetic field for causing migration of cells within the tissue of the patient; and
delivering a drug to the patient via the drug delivery assembly, the drug being delivered to the tissue of the patient exposed to the electromagnetic radiation.

14. The method according to claim 13 , wherein delivering the drug comprises delivering the drug to the patient through the plurality of needles, wherein the needles are microneedles carried by the base of the drug delivery device, the microneedles having a first end attached to a base of the drug delivery device and a second end spaced therefrom, the antenna disposed adjacent to the plurality of microneedles.

15. A drug delivery device comprising:
a base having a first region and a second region with adhesive disposed thereon, the first region disposed within a plane defined by the base;
a plurality of microneedles, each microneedle having a conical wall with a first end attached to the base and a second end spaced from the base and defining an opening, and an inner surface and an outer surface, the inner surface defining a needle reservoir in communication with the opening;
an antenna disposed in the first region of the base and adjacent to the first end of at least one of the plurality of microneedles; and
an electromagnetic field generator carried by the base and in electrical communication with the antenna, the antenna radiating an electromagnetic field that is generated by the electromagnetic field generator at least in a direction directly away from the base during use of the drug delivery device;
wherein the antenna is at least partially between at least two of the plurality of microneedles.

16. The drug delivery device of claim 15 , wherein the plurality of microneedles defines an array of microneedles, and the antenna is disposed in a pattern adjacent to the array of microneedles.

17. The drug delivery device of claim 16 , wherein the antenna is disposed in a serpentine pattern adjacent to the array of microneedles.

18. The drug delivery device of claim 15 , further comprising a controller coupled to the electromagnetic field generator and having a first state wherein the antenna is decoupled from the electromagnetic field generator and a second state wherein the controller couples the electromagnetic field generator to the antenna.

19. The drug delivery device of claim 1 , further comprising a container and a volume of the medicament in the container, the medicament comprising a monoclonal antibody (IgG) that binds human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).

20. The drug delivery device of claim 15 , further comprising a container and a volume of a medicament in the container, the medicament comprising a monoclonal antibody (IgG) that binds human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).

21. The drug delivery device of claim 1 , further comprising a container and a volume of the medicament in the container, the medicament comprising a granulocyte colony-stimulating factor (G-CSF).

22. The drug delivery device of claim 15 , further comprising a container and a volume of a medicament in the container, the medicament comprising a granulocyte colony-stimulating factor (G-CSF).

23. The method of claim 13 , wherein delivering the drug comprises delivering a monoclonal antibody (IgG) that binds human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).

24. The method of claim 13 , wherein delivering the drug comprises delivering a granulocyte colony-stimulating factor (G-CSF).

Assignees

• Amgen Inc

Inventors

• Toy Stephanie
• Lee Mark Ka Lai
• Busby Donald
• Norton Melissa D
• Chen Jeffrey

Classifications

• A61N1/0412

  Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs · CPC title

• A61N1/0428

  Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs · CPC title

• A61M37/00

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• A61N1/325

  for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body (electrodes for external use A61N1/0428) · CPC title

• A61M37/0015 Primary

  by using microneedles · CPC title