Topical compositions of dutasteride

Patent metadata

Field	Value
Publication number	US-10993934-B2
Application number	US-201816485152-A
Country	US
Kind code	B2
Filing date	Jun 18, 2018
Priority date	Jul 11, 2017
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

The present invention relates to a composition for topical application for preventing hair loss, androgenic alopecia (AA) and stimulating hair growth having dutasteride. The composition for topical application for preventing hair loss and stimulating hair growth according to the present invention provides equal or superior hair loss prevention and hair growth stimulating effects while using much smaller dosage than the conventional compositions (oral dosage form) which use finasteride and dutasteride.

First claim

We claim:

1. A composition for topical application for preventing hair loss and stimulating hair growth, the composition consisting of
(a) about 0.022 wt % (equivalent to 0.02% w/v) of dutasteride,
(b) about 30 wt % of medium chain triglycerides,
(c) about 30 wt % of ethanol and
(d) about 40 wt % of castor oil based on total weight of the composition, wherein dutasteride contained in the composition is in an amount to provide a daily dose of about 0.1 to about 0.5 mg.

Assignees

• Shilpa Medicare Ltd

Inventors

• Medishetty Rajendar
• Thippeswamy Agadihiremath
• Reddy Sreenivasa
• Pradeep Shivakumar

Classifications

• A61Q7/00

  Preparations for affecting hair growth · CPC title

• A61P17/14

  for baldness or alopecia · CPC title

• A61K47/44

  Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) · CPC title

• A61K47/14

  Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title