Compositions comprising non-crystalline forms of cannabidiol

Patent metadata

Field	Value
Publication number	US-10993928-B2
Application number	US-201916408428-A
Country	US
Kind code	B2
Filing date	May 9, 2019
Priority date	Apr 26, 2019
Publication date	May 4, 2021
Grant date	May 4, 2021

Abstract

Various aspects of this patent document relate to liquid compositions comprising cannabidiol, which have either freezing points or glass-liquid transition temperatures less than the melting point of pure cannabidiol.

First claim

What is claimed is:

1. A composition, comprising cannabidiol at a concentration of 50% to 99.5% by mass and one or more solutes selected from terpenes, terpene alcohols, and terpenoids at a combined concentration of 0.5% to 40% by mass, in which:
the one or more solutes are dissolved in the cannabidiol;
the composition has either a freezing point or a glass-liquid transition temperature; and
the freezing point or the glass-liquid transition temperature is either at least 50 degrees Fahrenheit less than the freezing point of pure cannabidiol or at least 27 degrees Celsius less than the freezing point of pure cannabidiol.

2. The composition of claim 1 , in which:
the composition has a freezing point;
the composition lacks a glass-liquid transition temperature; and
the freezing point is less than either 70 degrees Fahrenheit or 21 degrees Celsius.

3. The composition of claim 1 , in which:
the composition has a glass-liquid transition temperature;
the composition lacks a freezing point; and
the glass-liquid transition temperature is less than either 70 degrees Fahrenheit or 21 degrees Celsius.

4. The composition of claim 1 , in which the composition lacks crystals of cannabidiol.

5. The composition of claim 1 , in which the composition comprises cannabidiol at a concentration of 75% to 99% by mass.

6. The composition of claim 1 , in which the composition lacks tetrahydrocannabinol at a concentration greater than 0.3% by mass.

7. The composition of claim 1 , in which:
the composition comprises tetrahydrocannabinol at a concentration greater than 0.3% by mass;
the tetrahydrocannabinol is dissolved in the cannabidiol; and
the composition comprises cannabidiol and tetrahydrocannabinol at a ratio of 3:1 to 200:1 by mass.

8. The composition of claim 1 , comprising (6aS,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol at a concentration of 0.05% to 5% by mass, in which the (6aS,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol is dissolved in the cannabidiol.

9. The composition of claim 1 , in which the composition comprises molecules having a boiling point lower than either 360 degrees Fahrenheit or 182 degrees Celsius at a combined concentration of at least 95% by mass.

10. The composition of claim 1 , in which the composition lacks propylene glycol, glycerol, triglycerides, phospholipids, fatty acids, and waxes at a combined concentration greater than 5% by mass.

11. The composition of claim 1 , in which the composition is a liquid.

12. The composition of claim 11 , in which the composition has a viscosity, and the viscosity is less than 100 pascal-seconds at a temperature of either 70 degrees Fahrenheit or 21 degrees Celsius.

13. The composition of claim 12 , in which the viscosity is 50 millipascal-seconds to 50 pascal-seconds at a temperature of either 70 degrees Fahrenheit or 21 degrees Celsius.

14. The composition of claim 1 , in which the one or more solutes comprise one or more of alpha-bisabolol, alpha-phellandrene, alpha-pinene, alpha-terpinene, alpha-terpineol, beta-caryophyllene, beta-pinene, borneol, cadinene, camphene, camphor, caryophyllene oxide, citral, citronellol, delta-3-carene, eucalyptol, eugenol, gamma-terpinene, geraniol, guaiol, humulene, isopulegol, limonene, linalool, myrcene, nerol, nerolidol, ocimene, para-cymene, phytol, pulegone, terpineol, terpinolene, and valencene at a combined concentration of 0.5% to 40% by mass.

15. The composition of claim 1 , in which the one or more solutes comprise one or more of alpha-bisabolol, beta-caryophyllene, guaiol, humulene, limonene, myrcene, and terpinolene at a combined concentration of 0.5% to 40% by mass.

16. The composition of claim 1 , in which:
the composition comprises cannabidiol at a concentration of 65% to 99% by mass;
the composition lacks crystals of cannabidiol;
the composition lacks tetrahydrocannabinol at a concentration greater than 0.3% by mass;
the one or more solutes comprise one or more of alpha-bisabolol, beta-caryophyllene, guaiol, humulene, limonene, myrcene, and terpinolene at a combined concentration of 0.5% to 35% by mass;
the composition comprises molecules having a boiling point lower than either 360 degrees Fahrenheit or 182 degrees Celsius at a combined concentration of at least 95% by mass;
the composition lacks propylene glycol, glycerol, triglycerides, phospholipids, fatty acids, and waxes at a combined concentration greater than 5% by mass;
the composition has a glass-liquid transition temperature;
the glass-liquid transition temperature is less than either 70 degrees Fahrenheit or 21 degrees Celsius;
the composition lacks a freezing point;
the composition is a liquid; and
the composition has a viscosity, and the viscosity is 50 millipascal-seconds to 50 pascal-seconds at a temperature of either 70 degrees Fahrenheit or 21 degrees Celsius.

17. The composition of claim 1 , in which:
the composition comprises cannabidiol at a concentration of 65% to 99% by mass;
the composition lacks crystals of cannabidiol;
the composition comprises tetrahydrocannabinol at a concentration greater than 0.3% by mass;
the tetrahydrocannabinol is dissolved in the cannabidiol;
the composition comprises cannabidiol and tetrahydrocannabinol at a ratio of 3:1 to 200:1 by mass;
the one or more solutes comprise one or more of alpha-bisabolol, beta-caryophyllene, guaiol, humulene, limonene, myrcene, and terpinolene at a combined concentration of 0.5% to 35% by mass;
the composition comprises molecules having a boiling point lower than either 360 degrees Fahrenheit or 182 degrees Celsius at a combined concentration of at least 95% by mass;
the composition lacks propylene glycol, glycerol, triglycerides, phospholipids, fatty acids, and waxes at a combined concentration greater than 5% by mass;
the composition has a glass-liquid transition temperature;
the glass-liquid transition temperature is less than either 70 degrees Fahrenheit or 21 degrees Celsius;
the composition lacks a freezing point;
the composition is a liquid; and
the composition has a viscosity, and the viscosity is 50 millipascal-seconds to 50 pascal-seconds at a temperature of either 70 degrees Fahrenheit or 21 degrees Celsius.

Assignees

• Natural Extraction Sys Llc

Inventors

• Malcolm Nixon

Classifications

• A61K36/3482

  Cannabis · CPC title

• A61K31/658 Primary

  o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol · CPC title

• A61K36/348

  Cannabaceae · CPC title

• A61K36/5777

  Theobroma, e.g. cocao or cocoa · CPC title

• A61K36/3486

  Humulus · CPC title