Gas chromatography-ion mobility spectrometry detector and gas chromatograph-ion mobility spectrometer

Patent metadata

Field	Value
Publication number	US-10989689-B2
Application number	US-201816235315-A
Country	US
Kind code	B2
Filing date	Dec 28, 2018
Priority date	Dec 29, 2017
Publication date	Apr 27, 2021
Grant date	Apr 27, 2021

Abstract

A gas chromatography-ion mobility spectrometry detector and a hyphenated apparatus, the gas chromatography-ion mobility spectrometry detector comprises a gas chromatography mechanism and an ion mobility spectrometry mechanism. The gas chromatography mechanism comprises a chromatographic column and a sample injection port. The ion mobility spectrometry mechanism comprises a mobility tube and a connecting body, while a metal connection plate of the connecting body comprises a chromatographic metal plate, an ion mobility metal plate and a semipermeable membrane; on the ion mobility metal plate there are provided an ion mobility sample and carrier gas inlet, an ion mobility sample chamber and a sample injection port; the chromatography sample chamber and the ion mobility sample chamber are separated by semipermeable membrane.

First claim

What is claimed is:

1. A gas chromatograph-ion mobility spectrometer, comprising a gas path system, a gas chromatography mechanism and an ion mobility spectrometry mechanism, wherein
the gas chromatography mechanism comprises a chromatographic column and a sample injection port, and the sample injection port is positioned at one end of the chromatographic column and communicated with the chromatographic column;
the ion mobility spectrometry mechanism comprises a mobility tube and a connecting body, the connecting body is provided and communicated between the chromatographic column and the mobility tube, and the connecting body is provided with an ion mobility sample and carrier gas inlet, and a sample injection port communicated with each other; and
the gas path system comprises a chromatography gas path, a first mobility gas path and a second mobility gas path, the chromatography gas path is communicated with the sample injection port of the gas chromatography mechanism, a chromatography sample and carrier gas can enter into the chromatographic column via the chromatography gas path and the sample injection port, a part of sample molecules pre-separated through the chromatographic column can enter into the mobility tube; one end of the first mobility gas path is communicated with the mobility tube; the second mobility gas path is communicated with the mobility tube for supporting mobility gas to the mobility tube; mobility tube discharging gas discharged from the mobility tube can enter into the mobility tube via the first mobility gas path, the second mobility gas path and the ion mobility sample and carrier gas inlet, and the sample molecules can enter into the mobility tube via the sample injection port, under the action of the mobility sample and carrier gas, and is ionized, and then reach a Faraday plate under the action of a mobility electric field to be detected,
wherein the first mobility gas path comprises a first branch, a second branch and a third branch connected by a T-connector, the second branch is provided a molecular sieve and is communicated with the ion mobility sample and carrier gas inlet, and the third branch is provided a purifier and a microfiltration membrane, a part of the mobility tube discharging gas coming from the first branch enters into the second branch and the other part of the mobility tube discharging gas enters into the third branch.

2. The gas chromatograph-ion mobility spectrometer according to claim 1 , wherein the chromatography gas path comprises a filter, a combination valve and a flow controller, the chromatography sample and carrier gas can enter into the sample injection port via the filter, the combination valve and the flow controller.

3. The gas chromatograph-ion mobility spectrometer according to claim 1 , wherein the mobility tube comprises a positive mode tube, a negative mode tube, a positive discharging gas port and a negative discharging gas port, the positive mode tube and the negative mode tube are communicated by the connecting body, the positive discharging gas port is communicated with the positive mode tube, and the negative discharging gas port is communicated with the negative mode tube; the gas path system further comprises a cushioning bottom plate, the cushioning bottom plate comprises a first cushioning chamber and a second cushioning chamber, the first cushioning chamber is connected between the positive discharging gas port and the first mobility gas path, and the second cushioning chamber is connected between the negative discharging gas port and the first mobility gas path.

4. The gas chromatograph-ion mobility spectrometer according to claim 3 , wherein the mobility tube discharging gas coming from the first cushioning chamber and the second cushioning chamber is confluent at the first branch.

5. The gas chromatograph-ion mobility spectrometer according to claim 4 , wherein the cushioning bottom plate further comprises a third cushioning chamber, the first mobility gas path further comprises a fourth branch, while the second branch is connected with the third cushioning chamber, the fourth branch communicates the third cushioning chamber and the ion mobility sample and carrier gas inlet, and a flow controller is provided on the fourth branch.

6. The gas chromatograph-ion mobility spectrometer according to claim 5 , wherein the second mobility gas path comprises a positive mode branch and a negative mode branch, the positive mode branch is connected between the third cushioning chamber and the positive mode tube, and the negative mode branch is connected between the third cushioning chamber and the negative mode tube.

7. The gas chromatograph-ion mobility spectrometer according to claim 1 , further comprising an electric circuit, the electric circuit comprising a power module, a mainboard, a preamplifier module, a positive voltage module, a heating module and a control module, the mainboard being used for connecting a mobility tube outgoing cable and for providing slots for the preamplifier module, the positive voltage module, a control board; the preamplifier module being used for shaping, filtering and amplifying a signal received by the Faraday plate; the positive voltage module being used for providing a hopping pulse to an ion gate, providing an electric field to an mobility area and to a grid-plate; the heating module being used for heating; the control module being used to modifying and controlling the heating as well as the start and stop of the gas chromatography-ion mobility spectrometer.

8. The gas chromatograph-ion mobility spectrometer according to claim 1 , further comprising a shielding shell which comprises a mobility tube heating shielding shell, a Faraday plate shielding cylinder, a mobility tube integral shielding shell, and a positive voltage and preamplifier shielding shell.

Assignees

• Nuctech Co Ltd
• Univ Tsinghua

Inventors

• Zhang Qingjun
• Zhu Weiping
• Li Yuanjing
• Chen Zhiqiang
• Zhao Ziran
• Liu Yinong
• Liu Yaohong
• Ma Qiufeng
• Li Ge
• Cao Biao
• Bai Nan

Classifications

• G01N30/7206

  interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title

• G01N27/622 Primary

  Ion mobility spectrometry · CPC title

• G01N2030/025

  Gas chromatography · CPC title

• G01N30/72

  Mass spectrometers {(mass spectrometers per se H01J49/00)} · CPC title

• G01N30/20

  using a sampling valve · CPC title