Nanochanneled device with electrodes and related methods

Patent metadata

Field	Value
Publication number	US-10987500-B2
Application number	US-201414449683-A
Country	US
Kind code	B2
Filing date	Aug 1, 2014
Priority date	Aug 1, 2013
Publication date	Apr 27, 2021
Grant date	Apr 27, 2021

Abstract

A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, electrodes and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.

First claim

The invention claimed is:

1. A nanochannel delivery device comprising:
a plurality of inlet microchannels;
a first electrode;
a second electrode;
a plurality of nanochannels; and
a plurality of outlet microchannels, wherein:
each inlet microchannel is in direct fluid communication with an outlet microchannel via a single nanochannel;
the single nanochannel is perpendicular to the inlet microchannel and the outlet microchannel with which it is in direct fluid communication; and
the first electrode is directly coupled to a first surface of the nanochannel delivery device.

2. The nanochannel delivery device of claim 1 , wherein the second electrode is directly coupled to a second surface of the nanochannel delivery device.

3. The nanochannel delivery device of claim 2 , wherein the second surface is a surface of a first inlet microchannel of the plurality of inlet microchannels, a first outlet microchannel of the plurality of outlet microchannels, or a first nanochannel of the plurality of nanochannels.

4. The nanochannel delivery device of claim 3 , wherein the first surface is a surface of the first inlet microchannel, the first outlet microchannel, or the first nanochannel.

5. The nanochannel delivery device of claim 3 , wherein the nanochannel delivery device is configured to control a release rate of molecules passing through the first nanochannel by application of a voltage to the first electrode and the second electrode.

6. The nanochannel delivery device of claim 5 , wherein the nanochannel delivery device comprises a second nanochannel of the plurality of nanochannels, and wherein application of the voltage to the first electrode and the second electrode does not control a release rate of molecules passing through the second nanochannel.

7. The nanochannel delivery device of claim 3 , wherein the first electrode comprises electrically-conductive material deposited on the first surface and the second electrode comprises electrically-conductive material deposited on the second surface.

8. The nanochannel delivery device of claim 1 wherein the nanochannel is oriented parallel to a primary plane of the nanochannel delivery device.

9. The nanochannel delivery device of claim 1 wherein an inlet microchannel of the plurality of inlet microchannels and an outlet microchannel of the plurality of outlet microchannels are in direct fluid communication with a common nanochannel of the plurality of nanochannels.

10. The nanochannel delivery device of claim 1 wherein:
individual inlet and outlet microchannels are arranged perpendicular to a primary plane of the nanochannel delivery device;
the plurality of inlet microchannels form a first array;
the plurality of outlet microchannels form a second array; and
the first array and the second array are overlapping so that individual inlet microchannels are distributed between individual outlet microchannels when viewed along a section taken perpendicular to the primary plane.

11. A nanochannel delivery device comprising:
an inlet channel;
an outlet channel; and
a nanochannel in fluid communication with the inlet channel and the outlet channel, wherein:
the nanochannel comprises a first surface and a second surface, wherein the first surface is substantially parallel to the second surface;
the nanochannel is perpendicular to the inlet channel; and
the nanochannel is perpendicular to the outlet channel;
the first surface and the second surface are electrically conductive.

12. The nanochannel delivery device of claim 11 , wherein nanochannel delivery device is configured to control a release rate of molecules passing through the nanochannel by application of a voltage to the first surface and the second surface.

13. The nanochannel delivery device of claim 11 wherein the first surface is electrically coupled to the second surface.

14. The nanochannel delivery device of claim 11 wherein the first surface and the second surface of the nanochannel are separated by a distance that is less than 500 nm.

15. The nanochannel delivery device of claim 11 wherein the first surface and the second surface of the nanochannel are separated by a distance that is less than 100 nm.

16. The nanochannel delivery device of claim 11 wherein the first surface and the second surface of the nanochannel are separated by a distance that is less than 50 nm.

17. The nanochannel delivery device of claim 11 wherein:
the first surface and the second surface of the nanochannel form a first electrode;
the nanochannel delivery device comprises a second electrode; and
at least one of the inlet channel and the outlet channel is between the nanochannel and the second electrode.

18. The nanochannel delivery device of claim 11 wherein the first surface and the second surface of the nanochannel are electrically coupled via a third surface extending substantially perpendicular to the first surface and the second surface of the nanochannel.

19. The nanochannel delivery device of claim 11 wherein during operation a voltage can be applied to the first surface and the second surface and movement of a fluid through the nanochannel can be controlled by varying the voltage.

20. The nanochannel delivery device of claim 11 wherein the nanochannel is in direct fluid communication with the first microchannel and the second microchannel.

21. A nanochannel delivery device comprising:
a first exterior surface and a second exterior surface;
a first electrode and a second electrode;
a nanochannel;
a first microchannel in fluid communication with the nanochannel; and
a second microchannel in fluid communication with the nanochannel, wherein:
the first microchannel extends from the nanochannel to the first exterior surface; the second microchannel extends from the nanochannel to the second exterior surface;
the nanochannel is perpendicular to the first microchannel; and
the nanochannel is perpendicular to the second microchannel channel;
the first electrode and the second electrode extend from the nanochannel to the first exterior surface.

22. The nanochannel delivery device of claim 21 , wherein the first electrode is directly coupled to a first surface of the nanochannel.

23. The nanochannel delivery device of claim 21 , wherein the second electrode is directly coupled to a second surface of the nanochannel.

24. The nanochannel delivery device of claim 21 , wherein the first electrode is directly coupled to a first end of the nanochannel proximal to the first microchannel.

25. The nanochannel delivery device of claim 21 , wherein the second electrode is directly coupled to a second end of the nanochannel proximal to the second microchannel.

26. The nanochannel delivery device of claim 21 , wherein nanochannel delivery device is configured to control a release rate of molecules passing through the nanochannel by application of a voltage to the first electrode and the second electrode.

27. The nanochannel delivery device of claim 21 wherein the nanochannel delivery device comprises a substantially planar body and wherein the first exterior surface and the second exterior surface are substantially parallel.

28. The nanochannel delivery device of claim 21 wherein the nanochannel is in direct fluid communication with the first microchannel and the second microchannel.

Assignees

• Univ Texas

Inventors

• Fine Daniel
• Grattoni Alessandro
• Ferrari Mauro
• Liu Xuewu
• Goodall Randal
• Hosali Sharath

Classifications

• B81C1/00071

  Channels · CPC title

• B81B2201/058

  Microfluidics not provided for in B81B2201/051 - B81B2201/054 · CPC title

• B81B2203/04

  Electrodes · CPC title

• A61M37/00 Primary

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title