Preservative system

Patent metadata

Field	Value
Publication number	US-10987292-B2
Application number	US-201315035648-A
Country	US
Kind code	B2
Filing date	Nov 11, 2013
Priority date	Nov 11, 2013
Publication date	Apr 27, 2021
Grant date	Apr 27, 2021

Abstract

Provided herein is a cost-effective and potent preservative system for a composition comprising a salicylate salt and a benzoate salt in an amount of from 0.2 weight % to 0.5 weight % by total weight of the composition and in a molar ratio of salicylate to benzoate of 1:6 to 1:1.2, wherein the composition has a pH of 5 or less. Further provided herein is a method of using a combination of a salicylate salt and a benzoate salt in a preservative system in a composition, and a method of preserving a composition.

First claim

We claim:

1. A composition comprising a preservative system,
wherein the preservative system comprises a salicylate salt and a benzoate salt,
wherein a total amount of the salicylate salt and the benzoate salt is from 0.2 to 0.6 weight % by total weight of the composition,
wherein a weight ratio of the salicylate to the benzoate is 1:5 to 1:1, and
wherein the pH of the composition is from 4 to 4.5.

2. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:4.5 to 1:1.2.

3. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:3.4 to 1:1.2.

4. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:3.33.

5. The composition of claim 1 , wherein the salicylate salt comprises sodium salicylate.

6. The composition of claim 1 , wherein the benzoate salt comprises sodium benzoate.

7. The composition of claim 1 , wherein the preservative system consists of the salicylate salt and the benzoate salt.

8. The composition of claim 1 , wherein the composition is free of preservatives other than those of the preservative system.

9. The composition of claim 1 , wherein the total amount of the salicylate salt and the benzoate salt is 0.25 to 0.4 weight %, by total weight of the composition.

10. The composition of claim 1 , wherein the total amount of the salicylate salt and the benzoate salt is 0.2 weight %, 0.25 weight %, 0.3 weight %, 0.35 weight %, 0.4 weight %, by total weight of the composition.

11. The composition of claim 1 , wherein the total amount of the salicylate salt and the benzoate salt is 0.4 weight % by total weight of the composition.

12. The composition of claim 1 , wherein the salicylate salt is sodium salicylate and the benzoate salt is sodium benzoate.

13. The composition of claim 12 , wherein the weight ratio of sodium salicylate to sodium benzoate is 1:4.7 to 1:3.

14. The composition of claim 12 , wherein the weight ratio of sodium salicylate to sodium benzoate is one of 1:5, 1:4.7, 1:4.5, 1:4, 1:3, 1:3.5, 1:2.5, 1:2, or 1:1.5.

15. The composition of claim 1 , wherein the composition is a liquid cleaning composition.

16. The composition of claim 12 , wherein the weight ratio of sodium salicylate to sodium benzoate is 1:3, and adequate microrobustness is achieved with an AUC value of greater than 75, as compared to an inadequate microrobustness with an AUC value of lower than 75 when salicylate is absent.

17. The composition of claim 1 , wherein the salicylate:benzoate weight ratio is 1:3, the total concentration of salicylate and benzoate is 0.4 weight %, and adequate microrobustness is achieved with an AUC value of greater than 75, as compared to an inadequate microrobustness with an AUC value of lower than 75 when salicylate is absent.

18. The composition of claim 1 , wherein the salicylate:benzoate weight ratio is 1:5, adequate microrobustness is achieved at pH values of 4 to 4.5 with an AUC value of greater than 75, as compared to an inadequate microrobustness with an AUC value of lower than 75 when the weight ratio of salicylate:benzoate is reduced further.

19. The composition of claim 1 , which is selected from body lotions, ointments, creams and salves.

Assignees

• Colgate Palmolive Co

Inventors

• Lewus Catherine
• Du-Thumm Laurence D
• Begum-Gafur Rehana
• Smith-Webster Kimdra
• Vandeven Mark

Classifications

• A61Q19/10

  Washing or bathing preparations · CPC title

• A61Q15/00

  Anti-perspirants or body deodorants (deodorisation of air A61L9/00) · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/368 Primary

  with carboxyl groups directly bound to carbon atoms of aromatic rings · CPC title

• A61K2800/5922

  At least two compounds being classified in the same subclass of A61K8/18 · CPC title