Eye coupling mechanism for noninvasive glucose measurements with polarized light

Patent metadata

Field	Value
Publication number	US-10987035-B2
Application number	US-201715683282-A
Country	US
Kind code	B2
Filing date	Aug 22, 2017
Priority date	Aug 22, 2016
Publication date	Apr 27, 2021
Grant date	Apr 27, 2021

Abstract

Embodiments concern coupling polarized light at two or more wavelengths across the aqueous humor of the eye (e.g., as part of a noninvasive glucose monitoring system). An approach discloses non-contact and minimal contact eye-coupling designs that are part of a system for providing glucose concentration levels via measurements acquired by passing two or more optical beams through the cornea/aqueous chamber in the eye. The approach provides for coupling the light to account for the index mismatch incurred while allowing for monitoring the light polarization. Specifically, in an embodiment the light transitions from the device, through the air, through the proximal side of the cornea, through the aqueous humor, through the medial side of the cornea, and through the air back into the device. Embodiments address the index of refraction mismatch and polarized light maintaining concerns with a coupling approach that can take the form of contact and non-contact mechanisms.

First claim

What is claimed is:

1. A system comprising:
first and second light sources respectively configured to generate a first light beam from the first light source having a first wavelength and a second light beam from the second light source having a second wavelength unequal to the first wavelength;
a polarizer configured to linearly polarize the first and second light beams to generate first and second linearly polarized light beams;
a polarization modulator to modulate a rotation of a plane of polarization of each of the first and second linearly polarized light beams to generate first and second modulated light beams;
a first mirror configured to receive the first and second modulated light beams and transmit the first and second modulated light beams into a first half of an eye;
a second mirror configured to receive first and second phase shifted light beams, which correspond to the first and second modulated light beams, from a second half of the eye;
a signal processor configured to receive the first and second phase shifted light beams and configured to convert the first and second phase shifted light beams into first and second signals;
wherein the first mirror is adjustable for alignment and the second mirror has a concave reflective surface; and
wherein the first and second phase shifted light beams respectively include first and second phase shifts in response to the first and second modulated light beams contacting an analyte in an aqueous humor of the eye.

2. The system of claim 1 wherein the concave reflective surface includes a metal.

3. The system of claim 2 wherein the metal is selected from the group comprising gold and silver.

4. The system of claim 1 wherein: the first and second wavelengths are both between 400 and 900 nm; and the concave reflective surface includes a material configured to reflect the first and second wavelengths.

5. The system of claim 1 comprising a third mirror to receive the first and second phase shifted light beams from the second mirror and transmit the first and second phase shifted light beams to the signal processor.

6. The system of claim 5 comprising a fourth mirror to receive the first and second modulated light beams and transmit the first and second modulated light beams to the first mirror.

7. The system of claim 1 comprising a third mirror to receive the first and second modulated light beams and transmit the first and second modulated light beams to the first mirror.

8. The system of claim 7 , wherein at least one the first and third mirrors includes a concave reflective surface and at least another of the first and third mirrors includes a predominantly a reflective surface.

9. The system of claim 1 ; wherein at least one the first and second mirrors is respectively configured to rotate to adjust an angle at which at least one of (a) the first and second modulated light beams are transmitted to the eye, and (b) the first and second phase shifted light beams are received from the eye.

10. The system of claim 9 , comprising: a motor; and a feedback loop; wherein the motor is configured to pivot the at least one the first and second mirrors in response to feedback from the feedback loop.

11. The system of claim 1 wherein the first mirror is arranged to transmit the first and second modulated light beams into the eye in an anterior direction at an angle of between 10 and 20 degrees from a coronal plane that intersects the eye.

12. The system of claim 11 wherein the second mirror is arranged to receive the first and second phase shifted light beams traveling from the eye in a posterior direction.

13. The system of claim 11 wherein each of the first and second mirrors is less than 4 mm in diameter.

14. The system of claim 1 including eye glass frames coupled to the first and second mirrors.

15. The system of claim 14 comprising: a lens coupled to the eye glass frames; and an additional light source configured to transmit a first image onto the lens.

16. The system of claim 15 wherein the additional light source is configured to transmit the first image onto the lens at a location such that the eye must be focused in a direction selected from group consisting of laterally and medially.

17. The system of claim 1 comprising a contact lens configured to be placed upon the eye and so that the first and second modulated light beams from the first mirror pass through the contact lens to match an index of refraction of air with an index of refraction of tissue of the eye.

Assignees

• Texas A & M Univ Sys

Inventors

• Cote Gerard
• Hanks John
• Pirnstill Casey

Classifications

• A61B5/6821

  Eye · CPC title

• A61B5/6803

  Head-worn items, e.g. helmets, masks, headphones or goggles · CPC title

• G02C11/00

  Non-optical adjuncts; Attachment thereof (G02C7/16 takes precedence) · CPC title

• A61B5/14507

  specially adapted for measuring characteristics of body fluids other than blood (devices for taking samples of body liquids A61B10/0045) · CPC title

• A61B5/14558 Primary

  by polarisation · CPC title