System and method for collecting plasma

Patent metadata

Field	Value
Publication number	US-10980934-B2
Application number	US-202016931333-A
Country	US
Kind code	B2
Filing date	Jul 16, 2020
Priority date	May 30, 2017
Publication date	Apr 20, 2021
Grant date	Apr 20, 2021

Abstract

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume.

First claim

What is claimed is:

1. A method for collecting plasma comprising:
(a) determining the weight and height of a donor;
(b) determining the hematocrit of the donor;
(c) calculating a donor plasma volume based, at least in part, on the weight and height of the donor and the hematocrit of the donor;
(d) calculating a target plasma volume to collect based, at least in part, on the calculated donor plasma volume and a target percentage of plasma;
(e) withdrawing whole blood from the donor through a venous-access device and a first line, the first line connected to a blood component separation device;
(f) introducing anticoagulant into the withdrawn whole blood through an anticoagulant line;
(g) separating the withdrawn whole blood into a plasma component and at least a second blood component;
(h) collecting the plasma component from the blood component separation device and into a plasma collection container;
(i) continuing steps (e) through (h) until the target plasma volume to collect is reached in the plasma collection container.

2. A method according to claim 1 , further comprising:
calculating a volume of anticoagulant to be collected with the plasma component in the plasma collection container, the volume of anticoagulant to be collected with the plasma component based, at least in part, on the hematocrit of the donor.

3. A method according to claim 2 , wherein the target plasma volume to collect is a target volume of pure plasma to collect plus the calculated volume of anticoagulant to be collected.

4. A method according to claim 2 , wherein the target plasma volume to collect is a target volume of pure plasma to collect in the plasma collection container, the target volume of pure plasma to collect based, at least in part, upon the volume of anticoagulant to be collected with the plasma component in the plasma collection container.

5. A method according to claim 1 , further comprising:
calculating the donor's body mass index based, at least in part on the weight and height of the donor, the donor plasma volume calculated based, at least in part, on the donor's body mass index.

6. A method according to claim 1 , wherein the target plasma volume to collect is calculated before withdrawing whole blood.

7. A method according to claim 1 , wherein the target percentage of plasma is between 26.5 and 29.5 percent of the donor's plasma volume.

8. A system for collecting plasma comprising:
a venous-access device for drawing whole blood from a donor and returning blood components to the donor;
a blood component separation device for separating the drawn blood into a plasma component and a second blood component, the blood component separation device having an outlet and being configured to send the plasma component to a plasma collection container;
a first line fluidly connected to the venous-access device and configured to transport drawn whole blood to the blood component separation device and return fluid within the blood component separation device to the donor, the flow through the first line being controlled by a first pump;
an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce anticoagulant into the drawn whole blood; and
a controller configured to control the operation of the blood component separation device and the first pump, the controller configured to calculate (1) a donor plasma volume based, at least in part, on a weight and height of the donor and a hematocrit of the donor, (2) a target plasma volume to collect based, at least in part, on the calculated donor plasma volume and a target percentage of plasma, and (3) a volume of plasma component collected within the plasma collection container, the controller configured to stop the first pump when the calculated volume of plasma component collected within the plasma collection container equals the target plasma volume to collect.

9. A system according to claim 8 , wherein the controller is further configured to calculate a volume of anticoagulant to be collected with the plasma component in the plasma collection container, the volume of anticoagulant to be collected with the plasma component based, at least in part, on the hematocrit of the donor.

10. A system according to claim 9 , wherein the target plasma volume to collect is a target volume of pure plasma to collect plus the calculated volume of anticoagulant to be collected.

11. A system according to claim 9 , wherein the target plasma volume to collect is a target volume of pure plasma to collect within the plasma collection container, the target volume of pure plasma to collect based, at least in part, upon the volume of anticoagulant to be collected with the plasma component in the plasma collection container, the controller configured to stop the first pump when the volume of pure plasma collected within the plasma collection container equals the target plasma collection volume.

12. A system according to claim 8 , wherein the controller is further configured to calculate the donor's body mass index based, at least in part on the weight and height of the donor, the donor plasma volume calculated based, at least in part, on the donor's body mass index.

13. A system according to claim 8 , wherein the target plasma volume to collect is calculated before withdrawing whole blood.

14. A system according to claim 8 , wherein the target percentage of plasma is between 26.5 and 29.5 percent of the donor's plasma volume.

15. A method for programming a blood processing device comprising:
(a) receiving, in a control system, a weight and height of a donor;
(b) receiving, in a control system, a hematocrit of the donor;
(c) calculating, using the control system, a donor plasma volume, the control system calculating the donor plasma volume based, at least in part, on the weight and height of the donor and the hematocrit of the donor;
(d) calculating, using the control system, a target plasma volume to collect, the control system calculating the target plasma volume to collect based, at least in part, on the calculated donor plasma volume and a target percentage of plasma;
(e) determining a target collection volume based, at least in part, on the calculated target plasma volume to collect; and
(f) programming a controller of a blood processing device with a blood processing end point, the blood processing end point being based, at least in part, on the target collection volume.

16. A method according to claim 15 , further comprising:
calculating, using the control system, a volume of anticoagulant to be collected with a plasma component in a plasma collection container, the control system calculating the volume of anticoagulant to be collected with the plasma component based, at least in part, on the hematocrit of the donor.

17. A method according to claim 16 , wherein the target plasma volume to collect is a target volume of pure plasma to collect, the target volume of pure plasma to collect based, at least in part, upon the volume of anticoagulant to be collected with the plasma component.

18. A method according to claim 17 , wherein the target collection volume is the target volume of pure plasma to collect.

19. A method according to claim 17 , wherein the target collection volume is the target volume of pure plasma to collect plus the calculated volume of anticoagulant to be collected in the plasma collection container.

20. A method according to claim 15 , further comprising:
calculating, using the control system, the donor's body mass index

Assignees

• Haemonetics Corp

Inventors

• Ragusa Michael

Classifications

• A61M1/38 Primary

  Removing constituents from donor blood and {storing or} returning remainder to body {, e.g. for transfusion} · CPC title

• A61M1/3693

  using separation based on different densities of components, e.g. centrifuging · CPC title

• A61M2230/207

  hematocrit · CPC title

• A61M2205/3306

  Optical measuring means · CPC title

• A61M2205/3393

  by weighing the reservoir · CPC title