System and method for collecting plasma

Patent metadata

Field	Value
Publication number	US-10980926-B2
Application number	US-202016866078-A
Country	US
Kind code	B2
Filing date	May 4, 2020
Priority date	May 30, 2017
Publication date	Apr 20, 2021
Grant date	Apr 20, 2021

Abstract

A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.

First claim

What is claimed is:

1. A method for collecting plasma comprising:
(a) determining a weight of a donor;
(b) determining a hematocrit of the donor;
(c) calculating a volume of anticoagulant to be collected with a plasma component in a plasma collection container, the volume of anticoagulant to be collected with the plasma component based, at least in part on the hematocrit of the donor;
(d) calculating a target volume of pure plasma to collect in the plasma collection container based, at least in part, on the weight of the donor;
(e) determining a target collection volume based, at least in part, on the calculated volume of anticoagulant and the calculated volume of pure plasma;
(f) withdrawing whole blood from the donor through a venous-access device and a draw line, the draw line connected to a blood component separation device;
(g) introducing anticoagulant into the withdrawn whole blood through an anticoagulant line at a predetermined ratio of anticoagulant to whole blood;
(h) separating the withdrawn whole blood into the plasma component and at least a second blood component using the blood component separation device;
(i) collecting the plasma component from the blood component separation device and into a plasma collection container;
(j) continuing steps (f) through (i) until the target collection volume is reached in the plasma collection container.

2. A method according to claim 1 , wherein the target collection volume is the calculated volume of pure plasma.

3. A method according to claim 1 , wherein the target collection volume is the calculated volume of pure plasma plus the calculated volume of anticoagulant.

4. A method according to claim 1 , wherein the calculated volume of anticoagulant is further based, in least in part, on the predetermined ratio of anticoagulant.

5. A method according to claim 1 , wherein the calculated volume of anticoagulant includes at least a portion of the anticoagulant to be introduced into the withdrawn blood and at least a portion of a volume of anticoagulant to be added during a priming step.

6. A method according to claim 1 , wherein calculating the volume of anticoagulant includes calculating the volume of anticoagulant before withdrawing whole blood.

7. A method according to claim 1 , wherein calculating the target volume of pure plasma includes calculating the target volume of pure plasma before withdrawing whole blood from the donor.

8. A system for collecting plasma comprising:
a venous-access device for drawing whole blood from a donor and returning blood components to the donor;
a blood component separation device for separating the drawn blood into a plasma component and a second blood component, the blood component separation device having an outlet and being configured to send the plasma component to a plasma container;
a blood draw line fluidly connected to the venous-access device and configured to transport drawn whole blood to the blood component separation device, the flow through the blood draw line being controlled by a blood draw pump;
an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce anticoagulant into the drawn whole blood; and
a controller configured to control the operation of the blood component separation device, the controller configured to calculate (1) a volume of anticoagulant to be collected with plasma component in the plasma container, the volume of anticoagulant to be collected with the plasma component based, at least in part on the hematocrit of the donor, (2) a target volume of pure plasma to collect in the plasma container based, at least in part, on the weight of the donor, and (3) a target collection volume based, at least in part, on the calculated volume of anticoagulant and the calculated volume of pure plasma, the system configured to stop the blood draw pump when the target collection volume is collected within the plasma container.

9. A system according to claim 8 , wherein the target collection volume is the calculated volume of pure plasma.

10. A system according to claim 8 , wherein the target collection volume is the calculated volume of pure plasma plus the calculated volume of anticoagulant to be collected in the plasma container.

11. A system according to claim 8 , wherein the volume of anticoagulant to be collected within the plasma container is further based, in least in part, on the predetermined ratio of anticoagulant.

12. A system according to claim 8 , wherein the volume of anticoagulant to be collected in the collected plasma component includes at least a portion of the anticoagulant to be introduced into the withdrawn blood and at least a portion of a volume of anticoagulant to be added during a priming step.

13. A system according to claim 8 , wherein the controller is configured to calculate the volume of anticoagulant before withdrawing whole blood from the donor.

14. A system according to claim 8 , wherein the controller is configured to calculate the target volume of pure plasma before withdrawing whole blood from the donor.

15. A method for programming a blood component processing device:
(a) receiving, in a control system, a weight of a donor;
(b) receiving, in the control system, a hematocrit of the donor;
(c) calculating, using the control system, a volume of anticoagulant to be collected with a plasma component in a plasma collection container of the blood component processing device, the control system calculating the volume of anticoagulant to be collected with the plasma component based, at least in part on the hematocrit of the donor;
(d) calculating, using the control system, a target volume of pure plasma to collect in the plasma collection container, the control system calculating the target volume of pure plasma based, at least in part, on the weight of the donor;
(e) determining a target collection volume based, at least in part, on the calculated volume of anticoagulant and the calculated volume of pure plasma; and
(f) programming a controller of the blood component processing device with a blood processing end point, the blood processing end point being based, at least in part on the target collection volume.

16. A method according to claim 15 , wherein the target collection volume is the calculated volume of pure plasma.

17. A method according to claim 15 , wherein the target collection volume is the calculated volume of pure plasma plus the calculated volume of anticoagulant to be collected in the plasma collection container.

18. A method according to claim 15 , wherein the volume of anticoagulant to be collected within the plasma collection container is further based, in least in part, on a predetermined ratio of anticoagulant.

19. A method according to claim 15 , wherein the volume of anticoagulant to be collected in the collected plasma component includes at least a portion of the anticoagulant to be introduced into the withdrawn blood and at least a portion of a volume of anticoagulant to be added during a priming step.

20. A method according to claim 15 , wherein the volume of anticoagulant to be collected with the plasma component in the plasma collection container is also based, at least in part, on a volume of anticoagulant to be added to the drawn whole blood.

21. A method according to claim 15 , wherein the blood processing end point is when the target collection volume has been collected within the plasma collection container.

22. A method according to claim 15 , wherei

Assignees

• Haemonetics Corp

Inventors

• Ragusa Michael

Classifications

• A61M2205/3393

  by weighing the reservoir · CPC title

• A61M2205/3379

  Masses, volumes, levels of fluids in reservoirs, flow rates · CPC title

• A61M2205/3327

  Measuring · CPC title

• A61M2205/3306

  Optical measuring means · CPC title

• A61M1/38 Primary

  Removing constituents from donor blood and {storing or} returning remainder to body {, e.g. for transfusion} · CPC title