Electroporation of tissue products
US-2015343101-A1 · Dec 3, 2015 · US
US10980903B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10980903-B2 |
| Application number | US-201716308200-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 8, 2017 |
| Priority date | Jun 9, 2016 |
| Publication date | Apr 20, 2021 |
| Grant date | Apr 20, 2021 |
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Methods and Apparatus are provided for irradiating a liquid with accelerated electrons. The liquid is prepared. The liquid is mixed with particles having at least one luminescent substance, where the particles are formed such that the particles are dispersed in the liquid after mixing. The liquid is irradiated with an electromagnetic radiation, which induces the at least one luminescent substance to luminesce. An actual value of a physical quantity characterizing the luminescence of the luminescent substance is detected. The liquid is irradiated with accelerated electrons until the detected actual value corresponds to a target value.
Opening claim text (preview).
The invention claimed is: 1. A method for irradiating a liquid with accelerated electrons, the method comprising: preparing the liquid; mixing the liquid with particles, which have at least one luminescent substance, wherein the particles are formed such the particles are dispersed in the liquid after mixing, wherein the particles are dispersed within the liquid when sinking and rising velocities of the particles within a non-flowing volume of the liquid are less than 100 nm/s; detecting an actual value of a physical quantity characterizing a luminescence of the luminescent substance in the liquid by irradiating the liquid with an electromagnetic radiation, which induces the at least one luminescent substance to luminesce; inactivating microorganisms in the liquid with a plurality of accelerated electrons by irradiating the liquid with the accelerated electrons until the actual value of the physical quantity characterizing the luminescence of the luminescent substance detected has changed from an initial value to a target value, wherein the physical quantity characterizing the luminescence of the luminescent substance is changed from the initial value to the target value by the accelerated electrons. 2. The method of claim 1 , wherein UV radiation or light is used as the electromagnetic radiation. 3. The method of claim 1 , wherein the particles comprise a base material upon whose surface the luminescent substance is applied and/or in which the luminescent substance is embedded. 4. The method of claim 3 , wherein the base material comprises a plastic. 5. The method of claim 3 , wherein the base material comprises a biocompatible material. 6. The method of claim 3 , wherein the luminescent substance is embedded in the base material, and the luminescent substance is fully encased by the base material, which is transparent with respect to the electromagnetic radiation. 7. The method of claim 1 , wherein the size and/or the density of the particles is selected such that the particles are dispersed in the liquid after mixing. 8. The method of claim 1 , further comprising forming the liquid into a fluid film before irradiating with accelerated electrons. 9. The method of claim 1 , wherein the physical quantity characterizing the luminescence of the luminescent substance comprises: luminescence lifetime, intensity of at least one wavelength of the luminescence, or a wavelength at which the luminescence reaches its maximum intensity. 10. The method of claim 1 , wherein detecting the initial value and the target value of the actual value of the physical quantity characterizing the luminescence of the luminescent substance is detected while irradiating the liquid with accelerated electrons.
Living organisms or biological materials · CPC title
Particle radiation, e.g. electron-beam, alpha or beta radiation · CPC title
Disinfection · CPC title
Ultraviolet [UV] radiation · CPC title
with electrons · CPC title
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