LRH-1 modulators

Patent metadata

Field	Value
Publication number	US-10980755-B2
Application number	US-201615758549-A
Country	US
Kind code	B2
Filing date	Sep 9, 2016
Priority date	Sep 10, 2015
Publication date	Apr 20, 2021
Grant date	Apr 20, 2021

Abstract

Disclosed herein are compositions and methods for modulating the liver receptor homolog-1.

First claim

What is claimed is:

1. A compound having the formula:

wherein
W 1 and W 2 are independently CH or N;
L 1 is C(O)NH—, —NHC(O)—,

or —NHC(NH)NH;
R 1 is

unsubstituted alkyl;
R 2 is unsubstituted tert-butyl;
R 3 is unsubstituted tert-butyl;
R 4 is —OR 22 ;
R 22 is hydrogen,

halogen, —CX 3 , —CHX 2 , —CH 2 X, —OCX 3 , —OCH 2 X, —OCHX 2 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O) NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
X is —Cl, —Br, —I, or —F;
wherein R 1 is not unsubstituted methyl or unsubstituted tert-butyl; and
wherein the compound does not have the formula

2. The compound of claim 1 , wherein
R 1 is unsubstituted C 1 -C 8 alkyl.

3. The compound of claim 1 , having the formula:

4. The compound of claim 1 , wherein R 1 is unsubstituted C 1 -C 6 alkyl.

5. The compound of claim 1 , wherein R 4 is —OH.

6. The compound of claim 1 , wherein R 1 is unsubstituted butyl, unsubstituted pentyl, or unsubstituted hexyl.

7. The compound of claim 1 , wherein R 1 is unsubstituted C 3 -C 5 alkyl.

8. The compound of claim 1 , wherein R 1 is unsubstituted n-butyl.

9. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

10. The compound of claim 1 , having the formula

Assignees

• Univ California

Inventors

• England Pamela M
• Cortez Felipe De Jesus

Classifications

• C07D207/337

  Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

• C07D333/24

  Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

• C07D213/56

  Amides · CPC title

• C07D333/22

  Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom · CPC title

• C07C317/46

  the carbon skeleton being further substituted by singly-bound oxygen atoms · CPC title