Extraction of materials from liquids

Patent metadata

Field	Value
Publication number	US-10976228-B2
Application number	US-202016813041-A
Country	US
Kind code	B2
Filing date	Mar 9, 2020
Priority date	Aug 21, 2018
Publication date	Apr 13, 2021
Grant date	Apr 13, 2021

Abstract

An apparatus for extracting a material from a liquid includes a concentration stage having a filter, a first path from the filter, and a second path from the filter. Under this configuration, the concentration stage accepts an initial liquid volume. A first liquid not having material collected by the filter is passed along the first path, and concentrated liquid having material therein, which is entrapped by the filter, is directed to the second path. The apparatus also includes an aerosolizing stage coupled to the concentration stage that converts the concentrated liquid into an aerosol and a drying stage that dries the aerosol such that material extracted from the aerosol onto a material substrate.

First claim

What is claimed is:

1. An apparatus that extracts materials from liquids, the apparatus comprising:
a concentration stage that accepts an initial liquid volume, the initial liquid volume having an initial concentration of a material, the concentration stage comprising:
a filter that accepts the initial liquid volume, collects the material from the initial liquid volume, produces a permeate that is substantially devoid of the collected material, and produces a retentate that has a higher concentration of the material than the initial concentration;
a recirculating loop comprising:
a concentrator reservoir that flows to the filter; and
a retentate control valve that controls flow back to the concentrator reservoir;

a first path from the filter that defines a conduit for the permeate; and
a second path from the filter that defines a conduit for the retentate;

an aerosolizing stage coupled to the second path, wherein the aerosolizing stage converts the retentate into an aerosol; and
a drying stage that dries the aerosol to extract the material, the extracted material collected onto a material substrate.

2. The apparatus of claim 1 , wherein:
the second path comprises a retentate control valve; and
the first path comprises:
a flow meter; and
a permeate control valve, wherein the permeate control valve is open and the retentate control valve is closed during collection of the material.

3. The apparatus of claim 2 , wherein the retentate control valve comprises:
a closed position;
an open position; and
an open to drain position, wherein the open to drain position provides a drain path to prime and clean the filter that directs fluid to a drain line and bypasses the aerosolizing stage.

4. The apparatus of claim 3 , wherein the drain path directs the liquid through the concentration stage and into the drain line and does not enter the aerosolizing stage.

5. The apparatus of claim 1 further comprising:
a pressure regulator that controls a pressure of the liquid in the concentration stage, the liquid in the concentration stage operated at a higher pressure than a pressure of a liquid source.

6. The apparatus of claim 1 , wherein:
the aerosolizing stage comprises:
a peristaltic pump; and
a nebulizer; and

the drying stage comprises:
a drying chamber,

wherein:
the peristaltic pump controls a flow of the liquid into the nebulizer;
the nebulizer receives the liquid and coverts the received liquid into aerosolized liquid droplets; and
the drying chamber receives the aerosolized liquid droplets and separates cellular material from the droplets.

7. The apparatus of claim 6 , wherein the peristaltic pump controls the flow of the liquid into the nebulizer at a flow rate, the flow rate substantially proportional to a drying capacity of the drying chamber.

8. The apparatus of claim 1 , further comprising a controller coupled to the concentration stage, the controller further coupled to the aerosolizing stage, wherein the controller automates liquid sample collection.

9. The apparatus of claim 8 , wherein the controller is further coupled to an analyzer station, such that liquid sample collection operates in parallel with the analyzer.

10. The apparatus of claim 1 , wherein the filter is a tangential flow filter.

11. A process for extracting materials from liquids, the process comprising:
introducing an initial liquid volume into a concentration stage, the initial liquid volume having an initial concentration of a material;
directing the initial liquid volume along a permeate path such that a portion of the initial liquid volume flows through a filter and toward a drain line, the filter for entrapping the material to produce a concentrated liquid, the concentrated liquid having a higher concentration of the material than the initial concentration; and
directing the concentrated liquid out of the concentration stage;
introducing a portion of the concentrated liquid into an aerosolizing stage comprising a nebulizer to produce aerosolized liquid droplets; and
heating the aerosolized liquid droplets in a drying stage comprising a drying chamber to extract the material from the liquid droplets.

12. The method of claim 11 further comprising providing the extracted material to an analyzer to classify particulates contained within the extracted material.

13. The method of claim 11 further comprising:
directing the concentrated liquid into a storage container; and
introducing a second liquid volume upon directing the concentrated liquid into the storage container.

14. The method of claim 11 further comprising controlling a pressure of the initial liquid volume upon introducing the initial liquid volume into the concentration stage, the pressure of the initial liquid volume being higher than a pressure of a liquid source.

15. The method of claim 11 further comprising controlling a flow rate of the concentrated liquid into the nebulizer, the flow rate being substantially proportional to a drying capacity of the drying chamber.

16. The method of claim 11 , wherein directing a concentrated liquid out of the concentration stage comprises directing the concentrated liquid along a retentate path into a storage container.

17. The method of claim 16 further comprising initiating a cleaning cycle, the cleaning cycle being initiated after directing the concentrated liquid along the retentate path into the storage container, the cleaning cycle further being initiated prior to introducing a second liquid volume into the concentration stage.

18. The method of claim 17 , wherein the cleaning cycle comprises directing a cleaning liquid along a drain path when:
a selector valve is in an open position;
a first control valve is in an open position; and
a second control valve is in a closed position.

19. An apparatus for extracting materials from liquids, the apparatus comprising:
a concentration stage that accepts an initial liquid volume, the initial liquid volume having an initial concentration of a material, the concentration stage comprising:
a filter that accepts the initial liquid volume, the filter further collects the material from the initial liquid volume, the filter further produces a permeate that is substantially devoid of the collected material, the filter further produces a retentate, the retentate having a higher concentration of the material than the initial concentration;
a permeate path from the filter, which defines a conduit for the permeate, the permeate path comprising:
a flow meter; and
a permeate control valve; and

a retentate path from the filter, which defines a conduit for the retentate, the retentate path comprising a retentate control valve;

an aerosolizing stage coupled to the retentate path, wherein the aerosolizing stage converts the retentate into an aerosol;
a drying stage that dries the aerosol to extract the material, wherein the extracted material is collected onto a material substrate;
a controller coupled to the concentration stage, the controller further coupled to the aerosolizing stage, wherein the controller automates liquid sample collection; and
an analyzer coupled to the controller, which operates in parallel with the liquid sample collection.

Assignees

• Battelle Memorial Institute

Inventors

• Bartko Andrew P
• Blohm Kurt
• Daly Ryan W
• Deal Aaron M
• Gibbons Scott M
• Lira-Gonzalez Susana
• Richetti Benjamin J
• Roehr Nathan
• Ronningen Theodore J
• Scheitlin Christopher

Classifications

• B01D65/02 Primary

  Membrane cleaning or sterilisation {; Membrane regeneration} · CPC title

• B01D2311/2523

  to feed side · CPC title

• B01D2311/2699

  Drying · CPC title

• B01D2321/16

  Use of chemical agents · CPC title

• G01N1/40

  Concentrating samples · CPC title