Recombinant microorganisms and methods for producing cannabinoids and cannabinoid derivatives
US-10563211-B2 · Feb 18, 2020 · US
Methods for producing cannabinoids and cannabinoid derivatives
US10975379B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10975379-B2 |
| Application number | US-202016791991-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 14, 2020 |
| Priority date | Apr 27, 2017 |
| Publication date | Apr 13, 2021 |
| Grant date | Apr 13, 2021 |
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- Title
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Abstract
Official abstract text for this publication.
The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of producing a cannabinoid or a cannabinoid derivative, the method comprising use of a geranyl pyrophosphate:olivetolic acid geranyltransferase (GOT) polypeptide comprising the amino acid sequence of SEQ ID NO:110 or SEQ ID NO:100, wherein the method comprises mixing the GOT polypeptide with olivetolic acid and GPP, and wherein cannabigerolic acid is produced as a precursor to the cannabinoid or cannabinoid derivative. 2. The method of claim 1 , wherein the cannabinoid is cannabigerolic acid monomethylether (CBGAM), cannabigerol, cannabigerol monomethylether, Δ 9 -trans-tetrahydrocannabinol, Δ 9 -tetrahydrocannabinolic acid, Δ 9 -tetrahydrocannabinolic acid A, Δ 9 -tetrahydrocannabinolic acid B, Δ 9 -tetrahydrocannabinolic acid-C 4 , Δ 9 -tetrahydrocannabinol-C 4 , Δ 9 -tetrahydrocannabivarinic acid, Δ 9 -tetrahydrocannabivarin, Δ 9 -tetrahydrocannabiorcolic acid, Δ 9 -tetrahydrocannabiorcol, Δ 7 -cis-iso-tetrahydrocannabivarin, Δ 9 -tetrahydrocannabinol, Δ 8 -tetrahydrocannabinolic acid, Δ 8 -trans-tetrahydrocannabinol, Δ 8 -tetrahydrocannabinol, cannabidiolic acid, cannabidiol, cannabidiol monomethylether (CBDM), cannabidiol-C 4 (CBD-C 4 ), cannabidiorcol (CBD-C 1 ), cannabitriol, cannabichromenic acid, cannabichromene, cannabinolic acid, cannabinol, cannabinol methylether, cannabinol-C4, cannabinol-C2, cannabidivarinic acid, cannabidivarin, tetrahydrocannabivarinic acid, tetrahydrocannabivarin, cannabichromevarinic acid, cannabichromevarin, cannabigerovarinic acid, cannabigerovarin, cannabicyclolic acid, cannabicyclol, cannabicyclovarin, cannabielsoic acid A, cannabielsoic acid B, cannabielsoinic acid, cannabielsoin, cannabicitranic acid, or cannabicitran.
Assignees
Inventors
Classifications
Genes encoding for enzymes or proenzymes · CPC title
Fatty-acyl-CoA synthase (2.3.1.86) · CPC title
Vectors or expression systems specially adapted for E. coli · CPC title
Geranyl-pyrophosphate—olivetolic acid geranyltransferase (2.5.1.102) · CPC title
Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2) · CPC title
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Frequently asked questions
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- What does patent US10975379B2 cover?
- The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
- Who is the assignee on this patent?
- Univ California
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1085. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).