Compounds, compositions and methods

Patent metadata

Field	Value
Publication number	US-10975034-B2
Application number	US-201916459754-A
Country	US
Kind code	B2
Filing date	Jul 2, 2019
Priority date	Jun 17, 2004
Publication date	Apr 13, 2021
Grant date	Apr 13, 2021

Abstract

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

First claim

What is claimed is:

1. A compound selected from the group consisting of:
N-[2-fluoro-5-({methyl[2-(methylamino)ethyl]amino}methyl)phenyl][(4-fluorophenyl)amino]carboxamide;
N-(2-{[(4-fluoro-3-{[(4-fluorophenyl)amino]carbonylamino}phenyl)methyl]methylamino}ethyl) methoxy-N-methylcarboxamide;
N-(2-{[(4-fluoro-3-{[(4-fluorophenyl)amino]carbonylamino}phenyl)methyl]methylamino}ethyl)-N-methylacetamide;
N-{2-fluoro-5-[(methyl{2-[methyl(methylsulfonyl)amino]ethyl}amino)methyl]phenyl}[(4-fluorophenyl)amino]carboxamide; and
N-{5-[({2-[(ethylsulfonyl)methylamino]ethyl}methylamino)methyl]-2-fluorophenyl}[(4-fluorophenyl)amino]carboxamide;
or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a pharmaceutically acceptable excipient, carrier or adjuvant and a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

Assignees

• Cytokinetics Inc

Inventors

• Morgan Bradley Paul
• Muci Alex
• Lu Pu-Ping
• Kraynack Erica Anne
• Tochimoto Todd
• Morgans Jr David J

Classifications

• C07D401/12 Primary

  linked by a chain containing hetero atoms as chain links · CPC title

• A61K31/42

  Oxazoles · CPC title

• A61K31/44

  Non condensed pyridines; Hydrogenated derivatives thereof · CPC title

• C07D401/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D213/75 Primary

  Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates · CPC title