Methods for treating inflammation and hypertension with γ-ketoaldehyde skavengers

Patent metadata

Field	Value
Publication number	US-10975033-B2
Application number	US-201214232615-A
Country	US
Kind code	B2
Filing date	Jul 12, 2012
Priority date	Jul 12, 2011
Publication date	Apr 13, 2021
Grant date	Apr 13, 2021

Abstract

A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.

First claim

We claim:

1. A method of treating or ameliorating an isoprostane induced inflammatory autoimmune response, comprising administering a gamma-ketoaldehyde scavenging effective amount to a patient in need thereof a compound of the following formula:

and stereoisomers and pharmaceutically acceptable salts thereof,
wherein the inflammatory autoimmune response includes at least one of hypertension, psoriasis, or edema.

2. A method of treating hypertension, comprising administering to a patient in need thereof an effective amount of a compound of the following formula:

and stereoisomers and pharmaceutically acceptable salts thereof.

3. A method of treating hypertension, comprising co-administering to a patient in need thereof a gamma-ketoaldehyde scavenging effective amount of a compound of the following formula:

and stereoisomers and pharmaceutically acceptable salts thereof, with an additional pharmaceutical agent known for at least one of treating inflammation, treating an isoprostane-induced autoimmune response, and reducing hypertension.

4. The method of claim 1 , wherein the co-administration is separate compositions given at the same time or at different times.

5. A method of treating psoriasis, comprising administering to a patient in need thereof an effective amount of a compound of the following formula:

and stereoisomers and pharmaceutically acceptable salts thereof.

Assignees

• Roberts Ii L Jackson
• Amarnath Venkataraman
• Harrison David G
• Kirabo Annet
• Univ Vanderbilt

Inventors

• Roberts Ii L Jackson
• Amarnath Venkataraman
• Harrison David G
• Kirabo Annet

Classifications

• A61K31/44

  Non condensed pyridines; Hydrogenated derivatives thereof · CPC title

• A61K31/137 Primary

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• C07C217/58

  with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• C07D213/65 Primary

  attached in position 3 or 5 · CPC title