Filtration system for preparation of fluids for medical applications

Patent metadata

Field	Value
Publication number	US-10973969-B2
Application number	US-201916423214-A
Country	US
Kind code	B2
Filing date	May 28, 2019
Priority date	Jan 7, 2005
Publication date	Apr 13, 2021
Grant date	Apr 13, 2021

Abstract

A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.

First claim

The invention claimed is:

1. A medicament preparation and disposal system, comprising:
a deionizing water filter containing a pretreatment filter, a UV module, and a resin module;
a fluid circuit with a plurality of controllable valves configured to select a flow path and direct a fluid received by the fluid circuit to a selected one of a medicament concentrate container, a batch container, a treatment machine, and a waste line having a conductivity sensor positioned along the waste line;
the fluid circuit being selectively connectable to receive medicament concentrate from the medicament concentrate container and to receive the fluid from the batch container;
the fluid circuit being selectively connectable to pump the fluid from the batch container to the treatment machine;
the fluid circuit being selectively connectable to pump fluid from the batch container to the waste line and past the conductivity sensor to thereby test a conductivity of the fluid from the batch container before conveying the fluid in the batch container to the treatment machine; and
the fluid circuit being selectively connectable to pump fluid from the batch container to the waste line to drain said batch container.

2. The system of claim 1 , further comprising a controller configured to control the fluid circuit with the plurality of controllable valves.

3. The system of claim 2 , wherein the controller is configured to connect the batch container to the waste line to empty when said controller detects that contents of the batch container are expired.

4. The system of claim 1 , wherein the fluid circuit includes four controllable valves and a pump.

5. The system of claim 1 , wherein said batch container is connected to the fluid circuit by two fluid lines.

6. The system of claim 5 , wherein one of said two fluid lines has a check valve with predefined cracking pressure.

7. The system of claim 1 , wherein the batch container has a fluid warmer.

8. The system of claim 6 , wherein the cracking pressure is about 3.5 pounds per square inch.

9. The system of claim 6 , wherein
the fluid circuit includes a first pump configured to pump fluid through the fluid circuit, and
said two fluid lines connecting the batch container to the fluid circuit are linked by a pumping tube segment driven by a second pump.

10. A fluid preparation system, comprising:
a disposable component with preconnected tubing, the disposable component including a sealed sterilized fluid circuit that includes
a sealed sterilized container;
a conductivity sensor preconnected to the container and in communication with an interior of said container;
at least one sealed connector adapted for adding fluid to said container; and
at least one sealed connector adapted for removing fluid from said container, wherein
said conductivity sensor is contained in a test line that is preconnected to the container, the test line being in communication with said interior and adapted to be connected to a source of suction thereby to draw a sample of contents of said container.

11. A system as in claim 10 , wherein said test line includes a check valve to prevent ingress of contaminants into said container.

12. A system as in claim 10 , wherein said at least one sealed connector is adapted for adding fluid to said container and includes an inline sterile filter.

13. A system as in claim 12 , further comprising:
a controller;
pumping actuators;
clamps controlled by the controller; and
a deionization water purifier with a product water outlet having a connector for connection to said sterile filter.

14. The system of claim 13 , wherein the fluid circuit includes a quantity of medicament concentrate.

15. The system of claim 14 , wherein said controller is programmed to pump said concentrate into said sterilized container and to dilute the same using water from the product water outlet.

16. The system of claim 15 , wherein the controller reads a fluid quality sensor reading from said conductivity sensor and controls a pump to continue or discontinue pumping responsively to said sensor reading.

17. The system of claim 16 , wherein said controller is programmed to maintain a clamp on a mixed fluid outlet of said sterilized container responsively to said sensor reading.

18. The system of claim 14 , wherein the controller reads a fluid quality sensor reading from said conductivity sensor and controls a pump to continue or discontinue pumping responsively to said sensor reading.

19. The system of claim 18 , wherein said controller is programmed to maintain a clamp on a mixed fluid outlet of said sterilized container responsively to said sensor reading.

Assignees

• Nxstage Medical Inc

Inventors

• Burbank Jeffrey H
• Treu Dennis M
• Friederichs Goetz
• Green Brian C
• Mcdowell Christopher S
• Brugger James M

Classifications

• A61M2205/12

  with interchangeable cassettes forming partially or totally the fluid circuit · CPC title

• A61M1/1656 Primary

  Apparatus for preparing dialysates · CPC title

• A61M1/167

  Flexible packaging for solid concentrates · CPC title

• C02F1/44

  by dialysis, osmosis or reverse osmosis {(general membrane separation processes B01D61/00, membrane modules B01D63/00, electrodialysis C02F1/4693, combination of membrane modules and bioreactors C02F3/1268)} · CPC title

• A61M1/1668

  Details of containers · CPC title