Matrices comprising a modified polysaccharide

Patent metadata

Field	Value
Publication number	US-10968285-B2
Application number	US-201816000370-A
Country	US
Kind code	B2
Filing date	Jun 5, 2018
Priority date	Aug 18, 2011
Publication date	Apr 6, 2021
Grant date	Apr 6, 2021

Abstract

The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.

First claim

The invention claimed is:

1. A plastic surgery implant consisting essentially of a matrix comprising:
at least one modified polysaccharide consisting of repeating disaccharide units, wherein the primary alcohol group is oxidized to a carboxylic acid group in at least 11% of the disaccharide units,
wherein the matrix further comprises at least one unmodified polysaccharide,
wherein the weight ratio of the modified polysaccharide to unmodified polysaccharide in the matrix is greater than 10 wt % of a modified polysaccharide, and
wherein the shear modulus G′ of the matrix is in the range of from 10 Pa to 10 7 Pa.

2. The plastic surgery implant of claim 1 , wherein the at least one modified polysaccharide is selected form the group consisting of a member of the carrageenan family, hyaluronic acid, heparin sulfate, dermatan sulfate, chondroitin sulfate, alginate, chitosan, pullulan, and agarose.

3. The plastic surgery implant of claim 1 , wherein the at least one modified polysaccharide is agarose.

4. The plastic surgery implant of claim 1 , wherein the at least one unmodified polysaccharide is selected from the group consisting of a member of the carrageenan family, hyaluronic acid, heparin sulfate, dermatan sulfate, chondroitin sulfate, alginate, chitosan, pullulan, and agarose.

5. The plastic surgery implant of claim 1 , wherein the at least one unmodified polysaccharide is agarose.

6. The plastic surgery implant of claim 1 , wherein the shear modulus G′ of the matrix is in the range of from 10 Pa to 100 kPa.

7. The plastic surgery implant of claim 1 , wherein one primary alcohol group is oxidized to a carboxylic acid group in at least 20-99% of the disaccharide units.

8. A method for reconstructive and cosmetic surgery, the method comprising implanting in plastic surgery a plastic surgery implant according to claim 1 .

9. A plastic surgery implant consisting essentially of a matrix comprising:
at least one modified agarose consisting of repeating disaccharide units, wherein one primary alcohol group is oxidized to a carboxylic acid group in at least 11% of the disaccharide units,
wherein the matrix further comprises at least one unmodified agarose,
wherein the weight ratio of the modified polysaccharide to unmodified polysaccharide in the matrix is greater than 10 wt % of a modified polysaccharide, and
wherein the shear modulus G′ of the matrix is in the range of from 10 Pa to 10 7 Pa.

Assignees

• Univ Freiburg Albert Ludwigs

Inventors

• Shastri V Prasad
• Forget Aurelien

Classifications

• C08B37/00 Primary

  Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof (cellulose D21; {microbiological processes C12P}) · CPC title

• A61Q90/00

  Cosmetics or similar toiletry preparations for specific uses not provided for in other groups of this subclass · CPC title

• C08B37/0069

  Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof · CPC title

• C08B37/0075

  Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof · CPC title

• C08B37/0039

  Agar; Agarose, i.e. D-galactose, 3,6-anhydro-D-galactose, methylated, sulfated, e.g. from the red algae Gelidium and Gracilaria; Agaropectin; Derivatives thereof, e.g. Sepharose, i.e. crosslinked agarose · CPC title