Microfluidic liquid-liquid contactor

Patent metadata

Field	Value
Publication number	US-10967352-B1
Application number	US-201815947673-A
Country	US
Kind code	B1
Filing date	Apr 6, 2018
Priority date	Apr 7, 2017
Publication date	Apr 6, 2021
Grant date	Apr 6, 2021

Abstract

An assembly comprises a first liquid guide having an inlet, an outlet, and a liquid-conducting layer comprising a first material. The liquid-conducting layer extends between the inlet and the outlet. A second liquid guide has an inlet, an outlet, and a liquid-conducting layer comprising a second material. The liquid-conducting layer extends between the inlet and the outlet. At least a portion of the liquid-conducting layer of the second liquid guide overlaps the liquid-conducting layer of the first liquid guide such that, when a first liquid flows along the liquid-conducting layer of the first liquid guide and a second liquid flows along the liquid-conducting layer of the second liquid guide, the second liquid contacts the first liquid along the portion of the liquid-conducting layer of the second liquid guide that overlaps the liquid-conducting layer of the first liquid guide.

First claim

The invention claimed is:

1. An assembly, comprising:
a first liquid guide having an inlet, an outlet, and a liquid-conducting layer comprising a porous member, the porous member comprising a first material, the first liquid guide further comprising one or more solid members arranged with the porous member in a stacked arrangement, the liquid-conducting layer extending between the inlet and the outlet; and
a second liquid guide having an inlet, an outlet, and a liquid-conducting layer comprising a second material that is different from the first material, the liquid-conducting layer extending between the inlet and the outlet;
wherein at least a portion of the liquid-conducting layer of the second liquid guide overlaps the liquid-conducting layer of the first liquid guide such that, when a first liquid is present in the liquid-conducting layer of the first liquid guide and a second liquid is present in the liquid-conducting layer of the second liquid guide, the second liquid contacts the first liquid along the portion of the liquid-conducting layer of the second liquid guide that overlaps the liquid-conducting layer of the first liquid guide.

2. The assembly of claim 1 , wherein the liquid-conducting layer of the first liquid guide comprises a mesh formed from a plurality of filaments.

3. The assembly of claim 1 , wherein the first material comprises a hydrophilic material such that the liquid-conducting layer of the first liquid guide is configured to conduct an aqueous liquid.

4. The assembly of claim 3 , wherein the second material comprises a hydrophobic material such that the liquid-conducting layer of the second liquid guide is configured to conduct an organic liquid.

5. The assembly of claim 4 , wherein:
the liquid-conducting layer of the first liquid guide comprises a metal screen; and
the liquid-conducting layer of the second liquid guide comprises a polymeric screen.

6. The assembly of claim 1 , wherein the liquid-conducting layer of the second liquid guide contacts the liquid-conducting layer of the first liquid guide along the portion of the liquid-conducting layer of the second liquid guide that overlaps the liquid-conducting layer of the first liquid guide.

7. The assembly of claim 1 , wherein:
the porous member is a first porous member; and
the one or more solid members of the first liquid guide include a first solid member situated adjacent the porous member and having a size and shape corresponding to a size and shape of the porous member.

8. The assembly of claim 7 , wherein:
the first solid member forms a first layer of the first liquid guide;
the first porous member is situated adjacent the first solid member and forms a second layer of the first liquid guide; and
the first liquid guide further comprises a third layer comprising a plurality of second porous members, the second porous members being situated adjacent the first porous member such that the first porous member is located between the first solid member and the second porous members.

9. The assembly of claim 8 , wherein the first liquid guide further comprises a fourth layer including a plurality of second solid members, the second solid members being situated adjacent the second porous members such that the first porous member and the second porous members are located between the first solid member and the second solid members.

10. The assembly of claim 9 , wherein lengths of the second porous members and lengths of the second solid members are less than a length of the first porous member.

11. The assembly of claim 9 , wherein:
the first porous member comprises an inlet portion and an outlet portion;
one of the second porous members is situated on the inlet portion of the first porous member; and
one of the second porous members is situated on the outlet portion of the first porous member.

12. The assembly of claim 1 , wherein the first and second liquid guides are situated in a housing.

13. The assembly of claim 12 , wherein:
the housing comprises one or more alignment pins; and
the porous member and the one or more solid members comprise one or more openings configured to receive the alignment pins.

14. A method, comprising:
situating a first liquid guide on a surface of a first housing portion, the first liquid guide having an inlet, an outlet, and a liquid-conducting layer comprising a porous member, the porous member comprising a first material, the first liquid guide further comprising one or more solid members arranged with the porous member in a stacked arrangement, the liquid-conducting layer extending between the inlet and the outlet;
situating a second liquid guide on the surface of the first housing portion such that at least a portion of a liquid-conducting layer of the second liquid guide overlaps the liquid-conducting layer of the first liquid guide, and such that when a first liquid flows along the liquid-conducting layer of the first liquid guide and a second liquid flows along the liquid-conducting layer of the second liquid guide, the second liquid contacts the first liquid along the portion of the liquid-conducting layer of the second liquid guide that overlaps the liquid-conducting layer of the first liquid guide, the liquid-conducting layer of the second liquid guide comprising a second material that is different from the first material, the liquid-conducting layer of the second liquid guide extending between an inlet and an outlet of the second liquid guide; and
securing a second housing portion to the first housing portion to enclose the first and second liquid guides.

15. The method of claim 14 , wherein:
situating the first liquid guide on the surface of the first housing portion further comprises stacking the porous member and the one or more solid members on the surface of the first housing portion.

16. The method of claim 15 , wherein:
the surface of the first housing portion further comprises one or more alignment pins; and
situating the first liquid guide on the surface of the first housing portion further comprises stacking the porous member and the one or more solid members such that the one or more alignment pins are received in corresponding openings defined in the porous member and the one or more solid members.

17. The method of claim 14 , further comprising situating a sealing member on the surface of the first housing portion.

18. A method, comprising:
flowing a first liquid through the first liquid guide of the assembly of claim 1 such that the first liquid flows from the inlet of the first liquid guide, along the liquid-conducting layer of the first liquid guide, to the outlet of the first liquid guide; and
flowing a second liquid through the second liquid guide such that the second liquid flows from the inlet of the second liquid guide, along the liquid-conducting layer of the second liquid guide, to the outlet of the second liquid guide;
wherein the second liquid contacts the first liquid along the portion of the liquid-conducting layer of the second liquid guide that overlaps the liquid-conducting layer of the first liquid guide.

Assignees

• Triad Nat Security Llc

Inventors

• Mcculloch Quinn
• Yarbro Stephen
• Chamberlin Rebecca
• Guengerich Quintessa

Classifications

• B01L2400/0406

  capillary forces · CPC title

• B01L2300/161

  Control and use of surface tension forces, e.g. hydrophobic, hydrophilic · CPC title

• B01L2200/12

  Specific details about manufacturing devices · CPC title

• B01L3/502753

  characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation · CPC title

• B01L2400/0487

  fluid pressure, pneumatics · CPC title