Adaptive system for blood fluid removal

Patent metadata

Field	Value
Publication number	US-10967112-B2
Application number	US-201715693535-A
Country	US
Kind code	B2
Filing date	Sep 1, 2017
Priority date	Apr 29, 2011
Publication date	Apr 6, 2021
Grant date	Apr 6, 2021

Abstract

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

First claim

What is claimed is:

1. A method carried out by a blood fluid removal system, comprising:
initiating a blood fluid removal session, using a blood fluid removal device, with initial system parameters;
acquiring a first set of data regarding one or more patient physiological parameters, wherein the one or more patient physiological parameters include at least one of pH and concentration of an electrolyte wherein at least one patient physiological parameter is measured in a dialysate;
storing the first data set in a most effective to date data set memory;
associating the initial system parameters in an increased effectiveness lookup table with the first data set;
adjusting at least one parameter of the blood fluid removal session by adjusting the dialysate to arrive at adjusted system parameters;
acquiring a second set of data regarding the one or more patient physiological parameters after the at least one parameter of the blood fluid removal session has been adjusted; and
determining which of the first and second set of data includes at least one value closer to a target value; storing in the increased effectiveness lookup table data regarding the data set having at least one value closer to the target value; and associating data regarding the adjusted system parameters with the data set having at least one value closer to the target value; and
repeating the process beginning with acquiring a first set of data regarding one or more patient physiological parameters;
storing the first data set in a least effective to date data set memory;
associating the initial system parameters in a decreased effectiveness lookup table with the first data set prior to adjusting the at least one parameter of the blood fluid removal session;
determining which of the first and second set of data includes at least one value further from the target value; storing in the decreased effectiveness lookup table data regarding the data set having at least one value further from the target value; and associating data regarding the adjusted system parameters with the data set having at least one value further from to the target value;
replacing the data in the least effective to date data set with the data from the data set having at least one value further from the target value; and
continuing the blood fluid removal session with the system parameters in the most effective to date data set;
wherein the blood fluid removal system performs at least one blood fluid removal process selected from the group consisting of ultrafiltration, hemofiltration, hemodialysis, hemodiafiltration and peritoneal dialysis.

2. The method of claim 1 , further comprising:
further adjusting at least one parameter of the blood fluid removal session to arrive at further adjusted system parameters;
acquiring a third set of data regarding the one or more patient physiological parameters after the at least one parameter of the blood fluid removal session has been further adjusted; and
determining which of the first and third sets of data includes at least one value and storing in the increased effectiveness lookup table data regarding the data set and associating data regarding the further adjusted system parameters with the data set having at least one value closer to the target value.

3. The method of claim 1 , further comprising:
further adjusting at least one parameter of the blood fluid removal session to arrive at further adjusted system parameters;
acquiring a fourth set of data regarding the one or more patient physiological parameters after the at least one parameter of the blood fluid removal session has been further adjusted; and
determining which of the first, second and fourth set of data includes at least one value further from the target value; and storing in the decreased effectiveness lookup table data regarding the data set having at least one value further from the target value and associating data regarding the further adjusted system parameters with the data set having at least one value further from the target value.

4. The method of claim 1 , further comprising:
acquiring a fifth set of data regarding one or more patient physiological parameters;
comparing the fifth data set to the increased effectiveness lookup table; and
determining whether at least one parameter of the data set stored in the increased effectiveness table is within a predetermined range of the fifth data set; and adjusting the system parameters associated with the data set stored in the increased effectiveness lookup table if the at least one parameter of the data set stored in the increased effectiveness lookup table is within the predetermined range of the fifth data set.

5. The method of claim 1 , further comprising:
stopping the blood fluid removal session;
acquiring a sixth set of data regarding one or more patient physiological parameters;
comparing the sixth data set to the increased effectiveness lookup table; and
initiating a second blood fluid removal session with the system parameters associated with the data set stored in the increased effectiveness lookup table if at least one parameter of a data set stored in the increased effectiveness lookup table is within a predetermined range of at least one parameter of the sixth data set.

6. The method of claim 1 , wherein the at least one of the one or more patient parameters also include at least one parameter selected from the group consisting of blood pressure and heart rate.

7. The method of claim 1 , wherein the electrolyte is potassium.

8. The method of claim 1 , wherein the system parameters comprise one or more of fluid removal rate and concentration of one or more electrolyte.

9. A blood fluid removal system, comprising:
a blood fluid removal medium configured to remove blood from a patient, wherein blood enters the medium, fluid is removed from the blood, and blood exits the medium;
one or more control elements configured to control (i) the rate at which the medium removed fluid from the blood or (ii) the concentration of electrolytes or pH in the blood that exits the medium;
one or more sensors configured to monitor one or more physiological parameter of the patient; wherein at least one physiological parameter of the patient is measured in a dialysate; and
control electronics comprising memory and a processor, wherein the control electronics are in operable communication with the one or more sensors and are operably coupled to the one or more control elements,
wherein the control electronics are configured to carry out a method of:
initiating a blood fluid removal session, using a blood fluid removal device, with initial system parameters;
acquiring a first set of data regarding one or more patient physiological parameters, wherein the one or more patient physiological parameters include at least one of pH and concentration of an electrolyte wherein at least one patient physiological parameter is measured in a dialysate;
storing the first data set in a most effective to date data set memory;
associating the initial system parameters in an increased effectiveness lookup table with the first data set;
adjusting at least one parameter of the blood fluid removal session by adjusting the dialysate to arrive at adjusted system parameters;
acquiring a second set of data regarding the one or more patient physiological parameters after the at least one parameter of the blood fluid removal session has been adjusted; and
determining which of the first and second set of data includes at least one value closer to a target value; storing in the increased effectiveness lookup table data regarding the data set having at least one value closer to the target value; and associating data regarding the adjusted

Assignees

• Medtronic Inc

Inventors

• Gerber Martin
• Burnes John
• Lyu Suping
• Manda Venkatesh R
• Pudil Bryant

Classifications

• G16H40/63

  for local operation · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title

• G16H20/17

  delivered via infusion or injection · CPC title

• A61M1/1603 Primary

  Regulation parameters · CPC title

• G16H50/70

  for mining of medical data, e.g. analysing previous cases of other patients · CPC title