Implantable intestinal reactor

Patent metadata

Field	Value
Publication number	US-10960191-B2
Application number	US-201615564105-A
Country	US
Kind code	B2
Filing date	Apr 4, 2016
Priority date	Apr 3, 2015
Publication date	Mar 30, 2021
Grant date	Mar 30, 2021

Abstract

The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed from, a semi-permeable or porous membrane. The reactor can also delimit, at least partially with the semi-permeable or porous membrane of same, a closed inner space. The reactor can comprise or carry enzymes or micro-organisms, in particular bacteria or yeast. The reactor is used for generating a chemical reaction with one or more molecules present in the intestine, or for producing one or more biologically active molecules. It can, in particular, be used for consuming sugars, disaccharides and simple sugars or producing essential amino acids or other molecules having a positive effect on the health.

First claim

The invention claimed is:

1. A device implantable in an intestinal cavity, comprising a reactor, a cord, an active product, and a fastener for keeping the reactor in place in the intestinal cavity, wherein:
said fastener is fastened to a fastening location on an intestinal or gastric wall;
the cord connects the reactor to the fastener, and extends at least between the fastening location and the intestinal cavity, said cord having a solid section preventing the movement of the active product through the cord so that the cord remains free of the active product; and
the active product is located in the interior or on the external surface of the reactor and comprises a chemical molecule that generates a chemical or biological reaction with one or more molecules present in an intestine, living microorganisms, or living eukaryotic cells.

2. The device according to claim 1 , wherein the reactor comprises a semi-permeable membrane, a semi-permeable coating, or another semi-permeable material.

3. The device according to claim 1 , wherein the reactor is fastened to the cord that secures it to the fastener.

4. The device according to claim 1 , wherein the cord is surrounded by cylindrical segments.

5. The device according to claim 1 , wherein the cord is mounted on a swivel.

6. The device according to claim 1 , wherein the fastener is selected from the group consisting of a gastric clip, a pyloric stent, and an intestinal stent.

7. The device according to claim 1 , wherein the reactor includes a semi-permeable or porous membrane, and defines a closed inner space.

8. The device according to claim 1 , wherein the reactor defines an inner space containing at least one active element or product.

9. The device according to claim 1 , wherein the reactor comprises a particulate or granular biocompatible material or a mass of biocompatible material.

10. The device according to claim 1 , wherein the reactor contains a material selected from the group consisting of:
a disaccharidase;
bacteria breaking down glucose;
enzymes breaking down gluten;
a digestive enzyme inhibitor and/or an anorectic hormone;
microorganisms producing one or more essential amino acids;
microorganisms breaking down cellulose;
microorganisms producing dimethyl-butanol; and
bacteria producing insulin, acetohexamide, or acarbose.

11. The device according to claim 1 , comprising genetically modified microorganisms that produce at least one molecule of therapeutic interest.

12. The device according to claim 1 , comprising a microorganism genetically modified to produce a molecule, the production of this molecule that is induced by a signaling molecule ingested by the host.

13. The device according to claim 1 , wherein the device generates at least one chemical reaction with one or more molecules present in the intestine or produces at least one biologically active molecule for the production of molecules of therapeutic interest or for the consumption of glucose present in the intestine before it is absorbed, the reactor comprising:
one or more enzymes of the disaccharidase type and glucose oxidase and/or a combination of glucose dehydrogenase, aldose reductase and NAD or NADP; or
microorganisms or eukaryotic cells capable of producing at least one molecule of therapeutic interest.

14. The device according to claim 1 , wherein the reactor includes at least two faces on the surface of at least upon one of which a biofilm of microorganisms is formed, said biofilm allowing a sowing of microbiota.

15. The device according to claim 1 , wherein the reactor includes one or more parts centered on the cord, said at least one or more parts having an essentially cylindrical shape or cross-section having at least one surface irregularity selected from the group consisting of:
a thickness variation in a longitudinal direction of the essentially cylindrical shape or cross-section;
a diameter variation along a diametrical direction of the essentially cylindrical shape or cross-section; and
a cavity set back from the essentially cylindrical shape or cross-section and having protuberances extending past the essentially cylindrical shape or cross-section.

16. The device according to claim 15 , wherein an outer surface of the one or more parts having an essentially cylindrical shape or cross-section has a surface irregularity comprising a helical shape or a twist segment shape.

17. The device according to claim 1 , wherein the length of the device is comprised between about 5 cm and about 150 cm.

18. A method of treating a mammal, human or animal, in which a device according to claim 1 is implanted, comprising fastening the fastener to the intestinal or gastric wall, and positioning the reactor in the intestinal lumen, owing to which the active element produces its biological or chemical effect.

19. The device according to claim 1 , wherein the active product is selected from the group consisting of an enzyme and a microorganism, and said active product alters the physicochemical conditions in the intestinal cavity and modifies the intestinal microbiota.

20. The device according to claim 1 , wherein the cord extends between the fastener and the reactor over a distance greater than the length of the reactor.

21. A device implantable in an intestinal cavity, comprising a reactor, a cord, an active product, and a fastener for keeping the reactor in place in the intestinal cavity, wherein:
said fastener is fastened to a fastening location on an intestinal or gastric wall;
the cord connects the reactor to the fastener, and extends at least between the fastening location and the intestinal cavity, said cord remaining free of the active product; and
the active product is located in the interior or on the external surface of the reactor and comprises a chemical molecule that generates a chemical with one or more molecules present in an intestine, or comprises a living microorganism or eukaryotic cell,
wherein when the active product is a chemical molecule, the chemical molecule is maintained in the reactor by a chemical matrix; and
wherein when the active product is a living microorganism or eukaryotic cell, said living microorganism or eukaryotic is immobilized on a face of the reactor in a biofilm.

Assignees

• Univ Grenoble Alpes
• Centre Hospitalier Univ Grenoble

Inventors

• Cinquin Philippe
• Schneider Dominique
• Maurin Max
• Martin Donald
• El Ichi Sarra
• Zebda Abdelkader
• Alcaraz Jean-Pierre
• Reche Fabian
• Tuvignon Patrick
• Thelu Jacques
• Le Gouellec Audrey
• Toussaint Bertrand

Classifications

• A61B5/6873

  Intestine · CPC title

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61M31/002 Primary

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title

• A61M25/04

  in the body, e.g. expansible {(A61M25/10, A61M16/0488 take precedence)} · CPC title

• B01D69/144

  containing embedded or bound biomolecules · CPC title