Production method for easy-to-take solid preparation, and easy-to-take solid preparation

Patent metadata

Field	Value
Publication number	US-10959915-B2
Application number	US-201615737939-A
Country	US
Kind code	B2
Filing date	Jun 28, 2016
Priority date	Jun 29, 2015
Publication date	Mar 30, 2021
Grant date	Mar 30, 2021

Abstract

The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that a coating processing for the easy-to-take property is simply performed by using a gelling agent in a dry process, without going through a wet condition, the easy-to-take solid preparation and the like.
The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein a compression-molded core is coated with a coating agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising directly applying only powder of the coating agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently loading and integrally compression-molding a core-molding material; a powder composition for coating the solid preparation, which comprises a water-soluble polymer to be used in the aforementioned production method, and the like.

First claim

The invention claimed is:

1. A dry-process method for the production of an easy-to-take solid preparation
comprising:
directly applying only powder of a coating agent to a mortar inner surface, a bottom end surface of an upper-pestle, and a top end surface of a lower-pestle, and
loading a core-molding material and integrally compression-molding a core so that the core becomes coated with the coating agent,
wherein the coating agent comprises at least one water-soluble polymer.

2. The method according to claim 1 , wherein the water-soluble polymer is selected from the group consisting of sodium carboxylmethylcellulose, sodium alginate, carrageenan, xanthan gum and gelatin.

3. The method according to claim 2 wherein the water-soluble polymer is sodium carboxylmethylcellulose.

4. The method according to claim 1 , wherein the coating agent further comprises a lubricant.

5. The method according to claim 4 , wherein the lubricant is selected from the group consisting of calcium stearate, magnesium stearate and sucrose fatty acid ester.

6. The method according to claim 1 , wherein the coating agent further comprises a lubricant.

7. The method according to claim 2 , wherein the coating agent further comprises a lubricant.

8. The method according to claim 3 , wherein the coating agent further comprises a lubricant.

Assignees

• Daicel Corp

Inventors

• Hamasaki Momoko
• SAKAGUCHI Anan
• Okabayashi Tomohito
• Hashikawa Naohiro
• Hiramura Takahiro

Classifications

• A61K9/2866 Primary

  Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose · CPC title

• A61K9/2893 Primary

  Tablet coating processes (mechanical aspects A61J3/06) · CPC title

• A61K9/282

  Organic compounds, e.g. fats · CPC title

• A61J3/06

  into the form of pills, lozenges or dragees · CPC title

• A61K9/2095

  Tabletting processes · CPC title