Integrated human organ-on-chip microphysiological systems

Patent metadata

Field	Value
Publication number	US-10954482-B2
Application number	US-201816134746-A
Country	US
Kind code	B2
Filing date	Sep 18, 2018
Priority date	Dec 9, 2011
Publication date	Mar 23, 2021
Grant date	Mar 23, 2021

Abstract

The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

First claim

What is claimed is:

1. A cartridge comprising a microfluidic device attached thereto, said microfluidic device comprising one or more fluid channels, said cartridge comprising a mating surface, said microfluidic device positioned between said surface of said cartridge and a substrate, said substrate clamping said microfluidic device in place through one or more attachments to said cartridge, wherein said mating surface comprises at least one fluidic channel disposed therein, wherein said at least one fluidic channel of the cartridge mating surface is positioned opposite one or more of said channels of said microfluidic device.

2. The cartridge of claim 1 , wherein said microfluidic device comprises cells.

3. The cartridge of claim 2 , wherein said cells are in said one or more fluid channels of said microfluidic device.

4. The cartridge of claim 1 , wherein said microfluidic device is an organ-chip comprising living cells that mimic one or more functions of cells in an organ.

5. The cartridge of claim 1 , wherein said cartridge comprises fluid inputs and outputs.

6. The cartridge of claim 5 , wherein said cartridge comprises a luer lock connector in fluid contact with at least one of the fluid inputs or outputs.

Assignees

• Harvard College

Inventors

• Ingber Donald E
• Bahinski Anthony
• Cunningham Robert
• Goss Josue A
• Hamilton Geraldine A
• Hinojosa Christopher David
• Levner Daniel
• Parker Kevin Kit

Classifications

• C12M23/58

  Reaction vessels connected in series or in parallel (combinations of bioreactors with other apparatus, C12M43/00) · CPC title

• A01N1/148

  with provisions specially adapted for transporting · CPC title

• A01N1/143

  for organ perfusion · CPC title

• A01N1/122

  Preservation or perfusion media · CPC title

• A01N1/10

  Preservation of living parts · CPC title