Biocompatible nanoparticle and use thereof

Patent metadata

Field	Value
Publication number	US-10954348-B2
Application number	US-201816040871-A
Country	US
Kind code	B2
Filing date	Jul 20, 2018
Priority date	Jan 20, 2016
Publication date	Mar 23, 2021
Grant date	Mar 23, 2021

Abstract

The present invention relates to a biocompatible nanoparticle and a use thereof and, more specifically, to a biocompatible nanoparticle formed by irradiation an electron beam to an aqueous solution comprising at least one substance selected from the group consisting of a polysaccharide, a derivative thereof and a polyethylene glycol, thereby inducing inter-molecular cross-linking or intra-molecular cross-linking, and to a use of the biocompatible nanoparticle in a drug carrier, a contrast agent, a diagnostic agent or an intestinal adhesion prevention agent or for disease prevention and treatment.

First claim

The invention claimed is:

1. A method for preparing biocompatible nanoparticles, the method comprising:
(a) adding to water, at least one material selected from the group consisting of polysaccharides, and a mixture of a polysaccharide and polyethylene glycol to prepare a 0.1% (w/v) to 15% (w/v) solution; and
(b) irradiating the solution prepared in step (a) with an electron beam at a dose of 5 to 250 kGy to crosslink the material, wherein the biocompatible nanoparticle is formed exclusively by inter-molecular or intra-molecular crosslinking of at least one selected from the group consisting of a polysaccharide, and a mixture of a polysaccharide and polyethylene glycol,
wherein the method excludes the use of a crosslinking agent, a curing agent, an inorganic material, and an organic solvent,
wherein the polysaccharide is at least one selected from the group consisting of mannan, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, fructo-oligosaccharides, isomalto-oligosaccharides, inulin, glycogen, amylose, carboxymethyl dextran, beta-glucan, fucoidan, and chondroitin,
wherein a size of the nanoparticle is in a range of 1 to 700 nm.

Assignees

• Kyungpook Nat Univ Ind Academic Coop Found

Inventors

• Yoo Jeongsoo
• Lee Woonghee

Classifications

• C08B37/18

  Reserve carbohydrates, e.g. glycogen, inulin, laminarin; Derivatives thereof (not used) · CPC title

• C08B33/04

  Ethers · CPC title

• A61K51/065

  conjugates with carriers being macromolecules · CPC title

• C08B37/0069

  Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof · CPC title

• A61K9/5161

  Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin · CPC title