Utilizing polymers and antibiotics to enhance antimicrobial activity and inhibit antibiotic resistance

Patent metadata

Field	Value
Publication number	US-10953039-B2
Application number	US-201816144040-A
Country	US
Kind code	B2
Filing date	Sep 27, 2018
Priority date	Sep 27, 2018
Publication date	Mar 23, 2021
Grant date	Mar 23, 2021

Abstract

Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

First claim

What is claimed is:

1. A method for treating a bacteria infection, comprising:
contacting the bacteria infection with a combination therapy comprising an antibiotic and a polycarbonate polymer, wherein the polycarbonate polymer enhances an antimicrobial activity of the antibiotic, and wherein the polycarbonate polymer is characterized by a chemical structure:

wherein “R 1 ” corresponds to a first functional group selected from a first group consisting of a first alkyl group and a first aryl group;
wherein “R 2 ” corresponds to a second functional group selected from a second group consisting of a second alkyl group and a second aryl group;
wherein “X” corresponds to a spacer structure selected from a third group consisting of a third alkyl group and a third aryl group; and
wherein “n” corresponds to an integer greater than or equal to 1 and less than or equal to one thousand.

2. The method of claim 1 , wherein the enhancing the antimicrobial activity of the antibiotic comprises interacting the polycarbonate polymer with a cytosolic member targeted by the antibiotic, wherein the cytosolic member is selected from a group consisting of a protein, an enzyme, and a gene.

3. The method of claim 1 , wherein the chemical structure is:

4. A method for reducing a minimum inhibitory concentration of an antibiotic selected from the group consisting of rifampicin, tetracycline, azithromycin, ciprofloxacin, ceftazidime, penicillin, gentamicin, and imipenem, comprising:
administering the antibiotic by a combination therapy comprising the antibiotic and a polycarbonate polymer, wherein the polycarbonate polymer enhances an antimicrobial activity of the antibiotic against a bacterium selected from the group consisting of Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa , and Klebsiella pneumoniae , and wherein the polycarbonate polymer is characterized by a chemical structure:

wherein “R 1 ” corresponds to a first functional group selected from a first group consisting of a first alkyl group and a first aryl group;
wherein “R 2 ” corresponds to a second functional group selected from a second group consisting of a second alkyl group and a second aryl group;
wherein “X” corresponds to a spacer structure selected from a third group consisting of a third alkyl group and a third aryl group; and
wherein “n” corresponds to an integer greater than or equal to 1 and less than or equal to one thousand.

5. The method of claim 4 , wherein the antibiotic is toxic.

6. The method of claim 4 , wherein the enhancing the antimicrobial activity comprises precipitating, by the polycarbonate polymer, a cytosolic member comprised within the bacterium, and wherein the cytosolic member is selected from a group consisting of a protein, an enzyme, and a gene.

7. A method for inhibiting a development of a resistance to an antibiotic by a bacterium, wherein the antibiotic is selected from the group consisting of rifampicin, tetracycline, azithromycin, ciprofloxacin, ceftazidime, penicillin, gentamicin, and imipenem, and wherein the bacterium is selected from the group consisting of Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa , and Klebsiella pneumoniae , the method comprising:
administering a mixture of the antibiotic and a polycarbonate polymer to the bacterium, wherein the polycarbonate polymer enhances an antimicrobial activity of the antibiotic, and wherein the polycarbonate polymer is characterized by a chemical structure:

wherein “R 1 ” corresponds to a first functional group selected from a first group consisting of a first alkyl group and a first aryl group;
wherein “R 2 ” corresponds to a second functional group selected from a second group consisting of a second alkyl group and a second aryl group;
wherein “X” corresponds to a spacer structure selected from a third group consisting of a third alkyl group and a third aryl group; and
wherein “n” corresponds to an integer greater or equal to 1 and less than or equal to one thousand.

8. The method of claim 7 , wherein the inhibiting comprises delaying the development of the resistance.

Assignees

• IBM
• Agency Science Tech & Res

Inventors

• Hedrick James L
• Bianco Simone
• Kunitomi Mark
• Yang Yi Yan
• Ding Xin
• Yang Chuan
• Liang zhen chang
• De Sessions Paola Florez
• Periaswamy Balamurugan

Classifications

• Y02A50/30

  Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

• A61K31/7052

  having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides · CPC title

• A61K31/785 Primary

  Polymers containing nitrogen · CPC title