Detecting apparatus and associated imaging method

Patent metadata

Field	Value
Publication number	US-10952701-B2
Application number	US-201615735759-A
Country	US
Kind code	B2
Filing date	Jun 16, 2016
Priority date	Jun 16, 2015
Publication date	Mar 23, 2021
Grant date	Mar 23, 2021

Abstract

The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising: —a holder comprising: —a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves, —a removable imaging device comprising: —a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18), —a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder, —an ultrasound probe (32), and —a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).

First claim

The invention claimed is:

1. Detecting apparatus for imaging at least two areas of a brain of a subject, a first area of the brain being distinct from a second area of the brain, the detecting apparatus being characterized in that the detecting apparatus comprises:
a holder comprising:
a frame devoted to be fixed, notably cemented, on a part of the skull of the subject, the frame delimitating an inner portion which is transparent to ultrasound waves,

a removable imaging device comprising:
a platform delimitating an inner space the inner space facing the inner portion,
a fixing element adapted to temporary fix and lock the platform to the holder,
an ultrasound probe comprising one or more transducer arrays, and
a moving stage holding the ultrasound probe, and being adapted to move the ultrasound probe within the inner space, the moving stage being adapted to move between a first position wherein the first area of the brain is imaged with the ultrasound probe and a second position wherein the second area of the brain is imaged with the ultrasound probe.

2. Detecting apparatus according to claim 1 , wherein the holder further comprises a window transparent to ultrasound waves, the window being inserted in the frame such that the window corresponds to the inner portion.

3. Detecting apparatus according to claim 1 , wherein the fixing element and the frame are magnetic.

4. Detecting apparatus according to claim 1 , wherein the frame further comprises an element having a first shape, the fixing element having a second shape, the first shape and the second shape being complementary.

5. Detecting apparatus according to claim 1 , wherein each transducer array is a linear transducer array.

6. Detecting apparatus according to claim 1 , wherein the moving stage comprises a movable screw.

7. Detecting apparatus according to claim 6 , wherein the moving stage further comprises a motor adapted to move the screw and a controller adapted to command the motor with a command law.

8. Detecting apparatus according to claim 7 , wherein the command law depends on at least one of the following elements:
the amplitude of reflected ultrasound signal obtained by the ultrasound probe over an object with a known position such as a wire or bead,
images obtained by the ultrasound probe using a Doppler technique,
images obtained by the ultrasound probe using an ultrasensitive Doppler technique, and
a reference structural atlas.

9. Detecting apparatus according to claim 7 , wherein the removable imaging device further comprises at least one additional sensor adapted to provide a continuous signal, each additional sensor being chosen among an electrode, an implanted electrode, an accelerometer, a camera adapted to film the subject and wherein the command law depends from the signal from the additional sensor.

10. Detecting apparatus according to claim 7 , wherein the removable imaging device further comprises a unique cable, the cable being positioned between the platform and the controller.

11. Detecting apparatus according to claim 1 , wherein the moving stage is a translating stage adapted to translate the ultrasound probe within the inner space.

12. Detecting apparatus according to claim 1 , wherein the moving stage is a rotating stage adapted to rotate the ultrasound probe around an axis within the inner space.

13. Method for imaging at least two areas of a brain of a subject, a first area of the brain being distinct from a second area of the brain, the method comprising the steps of:
providing a holder comprising:
a frame devoted to be fixed, notably cemented, on a part of the skull of the subject, the frame delimitating an inner portion which is transparent to ultrasound waves,

fixing, notably cementing, the frame to the part of the skull of the subject,
providing a removable imaging device comprising:
a platform delimitating an inner space, the inner space facing the inner portion,
a fixing element adapted to temporary fix and lock the platform to the holder,
an ultrasound probe comprising one or more transducer arrays, and
a moving stage holding the ultrasound probe and being adapted to move the ultrasound probe within the inner space,

fixing the platform to the holder with the fixing element,
imaging a first area of the brain with the ultrasound probe,
moving the ultrasound probe with the moving stage, and
imaging a second area of the brain with the ultrasound probe.

14. Method for imaging according to claim 13 , wherein the subject is awake.

Assignees

• Inst Nat Sante Rech Med
• Univ Pierre Et Marie Curie Paris 6
• Univ Paris Diderot—Paris 7
• Centre Nat Rech Scient
• Ecole Superieure Physique & Chimie Ind Ville De Paris
• Institut National De La Sante Et De Rech Medical Inserm

Inventors

• Deffieux Thomas
• Gennisson Jean-Luc
• Tanter Mickaël
• Cohen Ivan
• Pernot Mathieu

Classifications

• A61B8/145

  characterised by scanning multiple planes · CPC title

• A61B8/4411

  Device being modular · CPC title

• A61B8/4416

  related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions · CPC title

• A61B2503/40

  Animals · CPC title

• A61B8/488

  involving Doppler signals · CPC title