Hydrogel structure, blood vessel, internal organ model, practice tool for medical procedure, and method of manufacturing the hydrogel structure

Patent metadata

Field	Value
Publication number	US-10950143-B2
Application number	US-201715692833-A
Country	US
Kind code	B2
Filing date	Aug 31, 2017
Priority date	Aug 31, 2016
Publication date	Mar 16, 2021
Grant date	Mar 16, 2021

Abstract

A hydrogel structure includes a hollow tubular structure having an inner diameter of 1.0 mm or less, wherein the hydrogel structure has a transmission of 80 percent or more in a visible light range.

First claim

What is claimed is:

1. A hydrogel structure comprising:
a hollow tubular structure having an inner diameter of 1.0 mm or less,
wherein the hydrogel structure has a transmission of 80 percent or more in a visible light range, and wherein one of the following conditions are met:
(i) the hollow tubular structure comprises a first hydrogel object and is at least partially adjacent to a second hydrogel object having a modulus of elasticity different from that of the first hydrogel object, or
(ii) the hollow tubular structure comprises at least two kinds of hydrogel objects having different modulus of elasticity.

2. The hydrogel structure according to claim 1 , wherein the inner diameter is 0.3 mm or less.

3. The hydrogel structure according to claim 1 , wherein the transmission in the visible light range is 90 percent or more.

4. The hydrogel structure according to claim 1 , wherein the hollow tubular structure comprises a solid material in a hollow portion and a phase of the solid material is changed to a liquid state due to heat.

5. The hydrogel structure according to claim 4 , wherein the hollow tubular structure further comprises a coloring material in the hollow portion.

6. The hydrogel structure according to claim 1 , wherein the hollow tubular structure comprises a first hydrogel object and is at least partially adjacent to a second hydrogel object having a modulus of elasticity different from that of the first hydrogel object.

7. The hydrogel structure according to claim 1 , wherein the hollow tubular structure comprises at least two kinds of hydrogel objects having different modulus of elasticity.

8. The hydrogel structure according to claim 1 , wherein the hollow tubular structure comprises an inner wall at least part of which has an arithmetic surface roughness of 50 μm or less.

9. The hydrogel structure according to claim 1 , wherein the hollow tubular structure comprises an inner wall at least part of which has a coefficient of static friction of 0.1 or less.

10. A blood vessel model comprising:
the hydrogel structure of claim 1 .

11. An internal organ model comprising:
the hydrogel structure of claim 1 ,
wherein the hydrogel structure has an internal organ-like form.

12. A practice tool for medical procedure comprising:
the blood vessel model of claim 10 ; and
at least one of a catheter and an endoscope.

13. The practice tool for medical procedure according to claim 12 , further comprising an internal organ model, which comprises:
the hydrogel structure, wherein the hydrogel structure has an internal organ-like form.

14. A practice tool for medical procedure comprising:
the internal organ model of claim 11 ; and
at least one of a catheter and an endoscope.

15. A method of manufacturing a hydrogel structure including a hollow tubular structure, comprising:
forming a pillar-like core part with a core part forming material;
covering the pillar-like core part with a hydrogel forming material to form a tube-like portion; and
removing the pillar-like core part,
wherein the hydrogel forming material has a transmission of 80 percent or more in a visible light range, and wherein one of the following conditions are met:
(i) the hollow tubular structure comprises a first hydrogel object and is at least partially adjacent to a second hydrogel object having a modulus of elasticity different from that of the first hydrogel object, or
(ii) the hollow tubular structure comprises at least two kinds of hydrogel objects having different modulus of elasticity.

16. The method according to claim 15 , wherein the pillar-like core part and the tube-like portion are formed utilizing an additive manufacturing method.

17. The method according to claim 15 , wherein both of the core part forming material and the hydrogel forming material comprise an active energy ray curable composition.

18. The method according to claim 15 , wherein the pillar-like core part is liquefied by heat and removed.

19. A method of manufacturing a hydrogel structure including a hollow tubular structure, comprising:
forming a pillar-like core part with a core part forming material including an active energy ray curable composition; and
covering the pillar-like core part with a hydrogel forming material to form a tube-like portion,
wherein a cured object of the active energy ray curable composition is liquefied by heat,
wherein the hydrogel forming material has a transmission of 80 percent or more in a visible light range, and wherein one of the following conditions are met:
(i) the hollow tubular structure comprises a first hydrogel object and is at least partially adjacent to a second hydrogel object having a modulus of elasticity different from that of the first hydrogel object, or
(ii) the hollow tubular structure comprises at least two kinds of hydrogel objects having different modulus of elasticity.

Assignees

• Niimi Tatsuya
• Norikane Yoshihiro
• Matsumura Takashi
• Iwata Hiroshi
• Okada Noriaki
• Saito Takuya
• Ricoh Co Ltd

Inventors

• Niimi Tatsuya
• Norikane Yoshihiro
• Matsumura Takashi
• Iwata Hiroshi
• Okada Noriaki
• Saito Takuya

Classifications

• B33Y70/00

  Materials specially adapted for additive manufacturing · CPC title

• G09B23/30 Primary

  Anatomical models {(G09B23/281 - G09B23/288 take precedence)} · CPC title

• B29C64/40

  Structures for supporting 3D objects during manufacture and intended to be sacrificed after completion thereof · CPC title

• B29K2105/0002

  monomers or prepolymers · CPC title

• B29K2105/0061

  Gel or sol · CPC title