Nutritional compositions and methods for promoting cognitive development

Patent metadata

Field	Value
Publication number	US-10945446-B2
Application number	US-202016776777-A
Country	US
Kind code	B2
Filing date	Jan 30, 2020
Priority date	Jul 10, 2015
Publication date	Mar 16, 2021
Grant date	Mar 16, 2021

Abstract

A method for enhancing cognitive development in a pediatric subject involving administering to the subject a nutritional composition which includes up to 7 g/100 Kcal of a fat or lipid; up to 5 g/100 Kcal of a protein or protein equivalent source; 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk; 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acid; and 0.015 g/100 Kcal to 1.5 g/100 Kcal of a prebiotic.

First claim

What is claimed is:

1. A nutritional composition comprising:
up to 7 g/100 Kcal of a fat or lipid;
up to 5 g/100 Kcal of a protein source;
0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk, wherein the buttermilk comprises 6 mg/100 Kcal to 300 mg/100 Kcal of phospholipids, 1 mg/100 Kcal to 60 mg/100 Kcal of sphingomyelin, and 0.25 mg/100 Kcal to 7.5 mg/100 Kcal of gangliosides;
5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acids; and
a prebiotic.

2. The nutritional composition of claim 1 , wherein the buttermilk is present at a level of about 0.6 g/100 Kcal to about 15 g/100 Kcal.

3. The nutritional composition of claim 1 , wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid.

4. The nutritional composition of claim 3 , wherein the source of long chain polyunsaturated fatty acids further comprises arachidonic acid.

5. The nutritional composition of claim 4 , wherein the source of long chain polyunsaturated fatty acids is present at a level of about 5 mg/100 Kcal to about 75 mg/100 Kcal.

6. The nutritional composition of claim 5 , wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid and arachidonic acid at a ratio of arachidonic acid to docosahexaenoic acid of about 1:3 to about 9:1.

7. The nutritional composition of claim 1 , wherein the prebiotic is present at a level of about 0.015 g/100 Kcal to about 1.5 g/100 Kcal.

8. The nutritional composition of claim 1 , wherein the prebiotic comprises polydextrose and galactooligosaccharides.

9. The nutritional composition of claim 7 , wherein the polydextrose and galactooligosaccharides comprise at least about 20% of the prebiotic composition.

10. The nutritional composition of claim 1 , wherein the nutritional composition is an infant formula.

11. A nutritional composition comprising:
up to 7 g/100 Kcal of a fat or lipid;
up to 5 g/100 Kcal of a protein source;
0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk, wherein the buttermilk comprises 6 mg/100 Kcal to 300 mg/100 Kcal of phospholipids, 1 mg/100 Kcal to 60 mg/100 Kcal of sphingomyelin, and 0.25 mg/100 Kcal to 7.5 mg/100 Kcal of gangliosides;
5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acids;
a prebiotic; and
lactoferrin.

12. The nutritional composition of claim 11 , wherein the buttermilk is present at a level of 0.6 g/100 Kcal to 15 g/100 Kcal.

13. The nutritional composition of claim 11 , wherein the lactoferrin is present at a level of about 5 mg/100 Kcal to about 300 mg/100 Kcal.

14. The nutritional composition of claim 13 , wherein the lactoferrin is from a non-human source.

15. The nutritional composition of claim 11 , wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid, arachidonic acid, or a combination thereof.

16. The nutritional composition of claim 15 , wherein the source of long chain polyunsaturated fatty acids is present at a level of about 5 mg/100 Kcal to about 75 mg/100 Kcal.

17. The nutritional composition of claim 16 , wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid and arachidonic acid at a ratio of arachidonic acid to docosahexaenoic acid of about 1:3 to about 9:1.

18. The nutritional composition of claim 11 , wherein the prebiotic is present at a level of about 0.015 g/100 Kcal to 1.5 g/100 Kcal.

19. The nutritional composition of claim 11 , wherein the prebiotic comprises polydextrose and galactooligosaccharides.

20. The nutritional composition of claim 11 , wherein the nutritional composition is an infant formula.

Assignees

• Mead Johnson Nutrition Co

Inventors

• Ao Zihua
• Berseth Carol Lynn
• Cobb Patricia
• Gonzalez Juan M
• London Elisha
• Nguyen Minhthy
• Richards James David
• Rudolph Colin
• Alvey John D
• Maldonado Yadilka
• Kuang Chenzhong
• Xiao Yan
• Hondmann Dirk

Classifications

• A61K38/482 Primary

  Serine endopeptidases (3.4.21) · CPC title

• A23L33/19

  Dairy proteins · CPC title

• A61K31/714

  Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12 · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A23L33/21

  Addition of substantially indigestible substances, e.g. dietary fibres · CPC title