Device for manipulating magnetic particles and method for manipulating magnetic particles

Patent metadata

Field	Value
Publication number	US-10941394-B2
Application number	US-201515543425-A
Country	US
Kind code	B2
Filing date	Jan 15, 2015
Priority date	Jan 15, 2015
Publication date	Mar 9, 2021
Grant date	Mar 9, 2021

Abstract

A device for manipulating magnetic particles includes a gelled medium layer and liquid layers alternately stacked in a tubular container along a longitudinal direction of the container. A magnetic particle movement portion for moving magnetic particles exists along an inner wall surface of the container, and the magnetic particle movement portion extends along the longitudinal direction of the container. At a portion where the gelled medium layer is loaded, the cross-sectional shape of the container inner wall in a plane perpendicular to the longitudinal direction of the container is non-circular, and the shape of the magnetic particle movement portion in the cross section is a curved shape or an angular shape.

First claim

The invention claimed is:

1. A magnetic particle manipulation device comprising:
a container;
a magnet; and
an upper liquid layer, a gelled medium layer, and a lower liquid layer alternately stacked within the container in this order along a longitudinal direction of the container, wherein
an inner wall surface of the container includes a portion configured to move magnetic particles, the portion configured to move the magnetic particles extending along the longitudinal direction of the container at the gelled medium layer, and
in a cross section perpendicular to the longitudinal direction of the container at the portion configured to move the magnetic particles, a cross-sectional shape of the inner wall surface of the container is a non-circular curved shape including an inflection point or an angular shape, and
the magnet faces an outer wall surface of the container at the inflection point or the angular shape of the portion configured to move the magnetic particles, and the magnet is configured to be moved in the longitudinal direction along the outer wall surface of the container.

2. The magnetic particle manipulation device according to claim 1 , wherein r<(2S/π) 1/2 is satisfied in the cross section, where r is a curvature radius of the inner wall surface at the portion configured to move the magnetic particles, and S is a cross-sectional area within the inner wall surface of the container.

3. The magnetic particle manipulation device according to claim 1 , wherein the cross-sectional shape of the inner wall surface of the container has a straight line portion.

4. The magnetic particle manipulation device according to claim 1 , wherein the magnetic particles to be moved in the container are loaded in the container.

Assignees

• Shimadzu Corp

Inventors

• Kanai Masaki
• Ohashi Tetsuo
• Nishimoto Takahiro

Classifications

• B03C1/01

  by addition of magnetic adjuvants · CPC title

• B01L2200/0673

  Handling of plugs of fluid surrounded by immiscible fluid · CPC title

• B03C1/0332

  using permanent magnets · CPC title

• B03C1/30

  Combinations with other devices, not otherwise provided for · CPC title

• C07K1/14

  Extraction; Separation; Purification · CPC title