Blood component separation device and blood component separation method

Patent metadata

Field	Value
Publication number	US-10940260-B2
Application number	US-201716086259-A
Country	US
Kind code	B2
Filing date	Mar 13, 2017
Priority date	Mar 21, 2016
Publication date	Mar 9, 2021
Grant date	Mar 9, 2021

Abstract

Provided is a blood component separation device and related method, each capable of separating a blood component from blood and rapidly performing a virus inactivation process on the separated blood component. The blood component separation device includes a blood component separation section, provided in a centrifuge, configured to separate a blood component from blood by centrifugation, a diluting section configured to dilute, in a diluent containing riboflavin, concentrated red blood cells separated by the blood component separation section, and a UV light emitting unit configured to perform a virus inactivation process by exposing the concentrated red blood cells thus diluted to the UV light.

First claim

The invention claimed is:

1. A blood component separation device, the device comprising:
a centrifugal separation device;
a blood component separation section configured to separate a blood component from blood by centrifugation;
a diluting section configured to dilute, in a diluent containing a photoactive virus inactivation agent, the blood component separated by the blood component separation section;
a blood-component virus inactivation section configured to perform a virus inactivation by exposing the diluted blood component to a UV light source; and
a concentration adjustment section,
wherein the blood component separation section and the concentration adjustment section are disposed within the centrifugal separation device.

2. The blood component separation device according to claim 1 , wherein the concentration adjustment section is configured to adjust a concentration of the blood component that has been subjected to the virus inactivation process.

3. The blood component separation device according to claim 2 , wherein the concentration adjustment section adjusts the concentration of the blood component by centrifuging the blood component.

4. The blood component separation device according to claim 3 , wherein the blood component separation section and the concentration adjustment section are provided in a same centrifugal separation section of the centrifugal separation device.

5. The blood component separation device according to claim 2 , wherein the concentration adjustment section includes a filter, and
wherein the concentration of the blood component is adjusted by flowing the blood component into the filter in one direction to catch the blood component in the filter, and then flowing a liquid component in an opposite direction across the filter to collect the blood component.

6. The blood component separation device according to claim 1 , wherein the blood component is concentrated red blood cells.

7. The blood component separation device according to claim 1 , wherein the blood component is platelets.

8. The blood component separation device according to claim 6 , further comprising a plasma virus inactivation section configured to perform a virus inactivation process on plasma separated by the blood component separation section.

9. The blood component separation device according to claim 6 , further comprising a platelet virus inactivation section configured to perform a virus inactivation process on platelets separated by the blood component separation section.

10. A blood component separation method, the method comprising:
separating a blood component from blood by centrifugation;
diluting, in a diluent containing a photoactive virus inactivation agent, the separated blood component;
performing a virus inactivation by exposing the diluted blood component to a UV light; and
adjusting a concentration of the blood component subjected to UV light,
wherein the separating of the blood component from blood and the adjusting of the concentration of the blood component subjected to UV light occur in a single centrifugal separation device.

11. The method of claim 10 , wherein the adjusting of the concentration of the blood component subjected to UV light is performed using a filter.

12. The method of claim 10 , wherein the separating of the blood component from blood and the adjusting of the concentration of the blood subjected to UV light are provided in a same centrifugal separation section of centrifugal separation device.

Assignees

• Terumo Corp

Inventors

• IGARASHI Masatsugu

Classifications

• A61M1/3693

  using separation based on different densities of components, e.g. centrifuging · CPC title

• A61M2202/0429

  Red blood cells; Erythrocytes · CPC title

• B01D21/262

  by using a centrifuge · CPC title

• A61M2202/0427

  Platelets; Thrombocytes · CPC title

• B01D36/045

  Combination of filters with centrifugal separation devices · CPC title