Use of an acoustic wave in a chromatography system

Patent metadata

Field	Value
Publication number	US-10935527-B2
Application number	US-201916284942-A
Country	US
Kind code	B2
Filing date	Feb 25, 2019
Priority date	Mar 1, 2018
Publication date	Mar 2, 2021
Grant date	Mar 2, 2021

Abstract

The present invention relates to a method comprising using an acoustic wave in a chromatography system. The present invention also relates to a corresponding system and a corresponding use. The system may comprise a surface acoustic wave assembly, wherein the surface acoustic wave assembly comprises a sender unit comprising a sender transducer for sending an acoustic wave and a detection unit for detecting the acoustic wave, a substrate configured for propagation of the acoustic wave, wherein the sender transducer is connected to the substrate, wherein the substrate comprises a substrate section for propagation of the wave from the sender transducer, wherein this substrate section comprises a substrate surface, wherein the surface acoustic wave assembly further comprises at least one channel for conducting fluid, wherein this channel is partly defined by the substrate surface.

First claim

The invention claimed is:

1. A system for using an acoustic wave in a chromatography system, wherein the system comprises a surface acoustic wave assembly, wherein the surface acoustic wave assembly comprises
a sender unit comprising a sender transducer for sending an acoustic wave and a detection unit for detecting the acoustic wave,
a substrate configured for propagation of the acoustic wave,
wherein the sender transducer is connected to the substrate,
wherein the substrate comprises a substrate section for propagation of the wave from the sender transducer, wherein this substrate section comprises a substrate surface,
wherein the surface acoustic wave assembly further comprises at least a first channel for conducting solvent with a sample and a second channel for conducting solvent without the sample, wherein the solvent without the sample is used as a reference for a differential measurement, wherein the first and second channels are partly defined by the substrate surface.

2. The system according to claim 1 , wherein the system further comprises a measuring cell, and wherein the first and second channels are defined by the substrate surface and by the measuring cell, and wherein the measuring cell is disconnectable from the substrate.

3. The system according to claim 1 , wherein the detection unit comprises two receiver transducers.

4. The system according to claim 1 , wherein the at least one of the first and second channels comprises a U-channel having a general U-shape in the plane of the substrate surface.

5. The system according to claim 1 , wherein at least a part of the substrate is piezoelectric.

6. The system according to claim 1 , wherein the channel has a height perpendicular to the substrate surface not exceeding 0.4 mm.

7. A method comprising using an acoustic wave in a chromatography system, wherein the method utilizes the system according to claim 1 .

8. The method according to claim 7 , wherein the system further comprises a conduit connecting the first channel and the second channel, the method comprising
conducting a solvent through the first channel, through the conduit and through the second channel, and
supplying a sample to the solvent,
wherein when the solvent with the sample is conducted through the first channel, the solvent without the sample is conducted through the second channel, and
wherein the method further comprises using the solvent without the sample as a reference for a differential measurement.

Assignees

• Dionex Softron Gmbh

Inventors

• Baigar Erik
• Strobl Christoph

Classifications

• G01N2030/027

  Liquid chromatography · CPC title

• G01N2030/765

  for measuring mechanical vibrations · CPC title

• B01D15/10 Primary

  characterised by constructional or operational features · CPC title

• G01N30/76 Primary

  Acoustical detectors {(measurement of mechanical vibrations or ultrasonic, sonic or infrasonic waves G01H)} · CPC title

• G01N30/60

  Construction of the column · CPC title