Implantable medical devices

Patent metadata

Field	Value
Publication number	US-10933172-B2
Application number	US-201615088798-A
Country	US
Kind code	B2
Filing date	Apr 1, 2016
Priority date	Jul 24, 2009
Publication date	Mar 2, 2021
Grant date	Mar 2, 2021

Abstract

Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.

First claim

What is claimed is:

1. A method for producing a medical implant, comprising:
providing a bioresorbable ceramic matrix including a series of interconnected macropores defined by a plurality of interconnected struts, said interconnected struts each including a hollow interior;
impregnating said ceramic matrix with a biologically stable polymeric material such that at least a portion of said series of interconnected macropores is substantially filled with said polymeric material and said hollow interiors remain hollow to provide a composite blank, said polymeric material comprising a material selected from the group consisting of polyetheretherketone (PEEK), carbon-reinforced PEEK, and polyetherketoneketone (PEKK); and
processing said composite blank to provide an implant body including an external surface defining an outer profile of a configuration and shape for implantation, said implant body including a plurality of openings extending through at least a portion of said external surface and communicating with said hollow interior of at least a portion of said plurality of interconnected struts.

2. The method of claim 1 , wherein said external surface further includes an exposed area of said polymeric material and an exposed area of said ceramic matrix.

3. The method of claim 1 , wherein said hollow interiors are substantially free of said polymeric material.

4. The method of claim 1 , wherein said impregnating includes injection molding said polymeric material into and around said ceramic matrix.

5. The method of claim 1 , wherein said processing includes at least one of machining, cutting, etching, laser shaping and chemical degradation.

6. The method of claim 1 , wherein said implant body has a compressive strength of about 10 MPa.

7. The method of claim 1 , wherein:
said ceramic matrix comprises a calcium based ceramic material defined by a compound that includes elements of calcium, oxygen and phosphorous, wherein a portion of at least one of said elements is substituted with an element having an ionic radius of about 0.1 to about 0.6 Å; and
said ceramic matrix has a compressive strength of about 10 MPa.

8. The method of claim 1 , wherein said ceramic matrix comprises Skelite® and has a compressive strength of about 10 MPa.

9. The method of claim 1 , wherein said ceramic matrix is porous.

10. The method of claim 1 , wherein said ceramic matrix is formed of at least one of an osteoconductive material and an osteoinductive material configured to be capable of undergoing a bone remodeling process.

Assignees

• Warsaw Orthopedic Inc

Inventors

• Melkent Anthony J
• Thoren Brian R
• Smith Timothy J N
• Grant Ian D
• Dunkley Ian R

Classifications

• A61L27/425 Primary

  of phosphorus containing material, e.g. apatite · CPC title

• A61F2002/30973

  Two joined adjacent layers having complementary interlocking protrusions and recesses · CPC title

• B05D1/18

  performed by dipping · CPC title

• B29C2045/0058

  removing material · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title