Coolant mixtures

Patent metadata

Field	Value
Publication number	US-10933039-B2
Application number	US-201616099082-A
Country	US
Kind code	B2
Filing date	May 5, 2016
Priority date	May 5, 2016
Publication date	Mar 2, 2021
Grant date	Mar 2, 2021

Abstract

The invention relates to coolant mixtures containing: (a) at least one compound of formula (I), (b) at least one compound of formula (II) in which R 1 stands for hydrogen or a methyl group, R 2 stands for a methyl, ethyl or propyl group and n stands for 0, 1, or 2, and if applicable (c) an additional component.

First claim

The invention claimed is:

1. A coolant mixture comprising:
(a) at least one compound of the formula (I)

(b) at least one compound of the formula (II)

wherein R 1 is in each case hydrogen or a methyl group, R 2 is in each case a methyl, ethyl or propyl group and n is 0, 1 or 2; and (c) optionally a further coolant
wherein said mixture comprises:
(a) about 90 to about 99% by weight substances of the formula (I),
(b) about 1 to about 10% by weight substances of the formula (II), and
(c) 0 to about 90% by weight further coolants with the proviso that the components add up to 100% by weight.

2. The coolant mixture, according to claim 1 , wherein, said mixture comprises isobutyraldehyde or isovaleraldehyde or mixtures thereof as component (a).

3. The coolant mixture, according to claim 1 , wherein said mixture comprises isobutyric acid or isovaleric acid or mixtures thereof as component (b).

4. The coolant mixture, according to claim 1 , wherein said mixture comprises one selected from menthol, menthyl acetate, and mixtures thereof as component (c).

5. The coolant mixture, according to claim 1 said mixture comprises at least one mixture of components (a) and (b) selected from:
(i) isobutyraldehyde and isobutyric acid;
(ii) isovaleraldehyde and isovaleric acid;
(iii) isobutyraldehyde and isovaleric acid;
(iv) isovaleraldehyde and isobutyric acid; and
(v) isobutyraldehyde, isobutyric acid, isovaleraldehyde and isovaleric acid.

6. A preparation for oral administration comprising the coolant mixture, according to claim 1 .

7. The preparation, according to claim 6 , wherein said preparation takes a form of one selected from foodstuffs, pharmaceutical preparations, mouth compositions, dental care compositions, and combinations thereof.

8. The preparation, according to claim 7 , wherein said preparation takes a form of one selected from hard candies, chewy candies, and chewing gums.

9. The preparation, according to claim 7 , wherein said preparation takes a form of a cold remedy.

10. The preparation, according to claim 7 , wherein said preparation takes a form of one selected from toothpastes, mouthwashes, and medicinal chewing gums.

11. The preparation, according to claim 6 , wherein said preparation comprises the coolant mixture in an amount of from about 0.005 to about 5% by weight-based on the finished preparation.

12. A method for enhancing the cooling effect caused by a preparation on oral administration, the method comprising adding the coolant mixture, according to claim 1 , to the preparation.

13. The preparation according to claim 9 , wherein the cold remedy is one selected from syrups, sprays, and candies.

Assignees

• Symrise Ag

Inventors

• Siegel Sven
• Machinek Arnold
• Hölscher Bernd

Classifications

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/36

  Carboxylic acids; Salts or anhydrides thereof · CPC title

• A23G4/06

  characterised by the composition {containing organic or inorganic compounds} · CPC title

• A23L27/2028 Primary

  Carboxy compounds · CPC title

• A61K8/35

  Ketones, e.g. benzophenone · CPC title