Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues
US-9545340-B1 · Jan 17, 2017 · US
US10932901B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10932901-B2 |
| Application number | US-201815892987-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 9, 2018 |
| Priority date | Feb 10, 2017 |
| Publication date | Mar 2, 2021 |
| Grant date | Mar 2, 2021 |
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Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.
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We claim: 1. An optical device selected from a contact lens, intraocular lens, or corneal inlay for improving visual performance in a patient, including central optical and outer peripheral zones comprising an optical polymer material, wherein select regions of the optical device in the central and outer zones have been irradiated with a focused, visible or near-IR laser below the optical breakdown threshold of the optical polymer material to provide refractive structures that exhibit a change in refractive index, and exhibit little or no scattering loss, and wherein ablation or removal of the optical polymeric material is not observed in the irradiated regions, wherein laser-irradiated refractive structures provided in the central optical zone of the optical device provide one or more of the following when the optical device is employed by a patient: extended depth of focus by inducing a higher order aberration; diffractive multifocal; refractive multifocal; chromatic aberration correction; higher order aberration corrections; binocular monovision; rotationally symmetric or asymmetric single ring; or custom corrections; and further wherein laser-irradiated refractive structures provided in the peripheral zone of the optical device provide a region of altered refractive index to reduce glare, halo, edge effects or dysphotopsias. 2. An optical device according to claim 1 , wherein the optical device is an intraocular lens. 3. An optical device according to claim 2 , wherein refractive structures provided in the peripheral zone of the optical device provide a region of altered refractive index to reduce glare or halo effects caused by edges of the intraocular lens. 4. An optical device selected from a contact lens, intraocular lens, or corneal inlay for improving visual performance in a patient, including central optical and outer peripheral zones comprising an optical polymer material, wherein select regions of the optical device in the central and outer zones have been irradiated with a focused, visible or near-IR laser below the optical breakdown threshold of the optical polymer material to provide refractive structures that exhibit a change in refractive index, and exhibit little or no scattering loss, and wherein ablation or removal of the optical polymeric material is not observed in the irradiated regions, wherein laser-irradiated refractive structures provided in the central optical zone of the optical device provide one or more of the following when the optical device is employed by a patient: extended depth of focus by inducing a higher order aberration; diffractive multifocal; refractive multifocal; chromatic aberration correction; higher order aberration corrections; binocular monovision; rotationally symmetric or asymmetric single ring; or custom corrections; further wherein the optical device is an intraocular lens and the laser-irradiated refractive structures provided in the peripheral zone of the optical device provide a region of altered refractive index to reduce glare or halo effects caused by edges of the intraocular lens; and wherein refractive structures provided in the peripheral zone of the optical device comprise a refractive index GRIN layer added to the lens inside the periphery of the lens having a decreasing refractive index with increasing distance from the optical axis of the lens. 5. An optical device according to claim 4 , wherein refractive structures provided in the peripheral zone of the optical device reduce the refractive index of the polymer material to at or near the refractive index of surrounding aqueous fluid in use of the device in order to reduce internal reflections inside the lens that cause glare or halo effects. 6. An optical device according to claim 1 , wherein the optical device is a contact lens. 7. An optical device according to claim 6 , wherein refractive structures provided in the peripheral zone expand peripheral vision. 8. A method for modifying an optical device selected from a contact lens, intraocular lens, or corneal inlay for improving visual performance in a patient, wherein the optical device includes central optical and outer peripheral zones comprising an optical polymer material, comprising: modifying the refractive index of the optical polymer material in the central and outer peripheral zones by irradiating select regions with a focused, visible or near-IR laser below the optical breakdown threshold of the optical polymer material to provide refractive structures that exhibit a change in refractive index, and exhibit little or no scattering loss, and scanning over the select regions with the laser such that ablation or removal of the optical polymer material is not observed in the irradiated region, wherein refractive structures provided in the central optical zone of the optical device provide one or more of the following when the optical device is employed by a patient: extended depth of focus by inducing a higher order aberration; diffractive multifocal; refractive multifocal; chromatic aberration correction; higher order aberration corrections; binocular monovision; rotationally symmetric or asymmetric single ring; or custom corrections; and further wherein refractive structures provided in the peripheral zone of the optical device provide a region of altered refractive index to reduce glare, halo, edge effects or dysphotopsias. 9. A method according to claim 8 , wherein the optical device is an intraocular lens. 10. A method according to claim 9 , wherein refractive structures provided in the peripheral zone of the optical device provide a region of altered refractive index to reduce glare or halo effects caused by edges of the intraocular lens. 11. A method according to claim 8 , wherein the optical device is a contact lens. 12. An optical device according to claim 11 , wherein refractive structures provided in the peripheral zone expand peripheral vision. 13. A method for modifying an optical device selected from a contact lens, intraocular lens, or corneal inlay for improving visual performance in a patient, wherein the optical device includes central optical and outer peripheral zones comprising an optical polymer material, comprising: modifying the refractive index of the optical polymer material in the central and outer peripheral zones by irradiating select regions with a focused, visible or near-IR laser below the optical breakdown threshold of the optical polymer material to provide refractive structures that exhibit a change in refractive index, and exhibit little or no scattering loss, and scanning over the select regions with the laser such that ablation or removal of the optical polymer material is not observed in the irradiated region, wherein refractive structures provided in the central optical zone of the optical device provide one or more of the following when the optical device is employed by a patient: extended depth of focus by inducing a higher order aberration; diffractive multifocal; refractive multifocal; chromatic aberration correction; higher order aberration corrections; binocular monovision; rotationally symmetric or asymmetric single ring; or custom corrections; further wherein the optical device is an intraocular lens and the refractive structures provided in the peripheral zone of the optical device provide a region of altered refractive index to reduce glare or halo effects caused by edges of the intraocular lens; and wherein refractive structures provided in the peripheral zone of the optical device comprise a refractive index GRIN layer added to the lens inside the periphery of the lens having a decreasing refractive index with increasing distance from the
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