Antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and a diol, and cosmetic composition containing same

Patent metadata

Field	Value
Publication number	US-10932465-B2
Application number	US-201816626074-A
Country	US
Kind code	B2
Filing date	Jun 27, 2018
Priority date	Jun 30, 2017
Publication date	Mar 2, 2021
Grant date	Mar 2, 2021

Abstract

The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxy-phenyl)butan-2-one and an additional compound chosen from chlorhexidine digluconate, chlorhexidine hydrochloride and a polyhexamethylene biguanide salt, and also to a cosmetic composition containing such a mixture. Use in caring for, making up and cleansing keratin materials.

First claim

The invention claimed is:

1. An antimicrobial mixture comprising 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an additional compound chosen from:
i) a chlorhexidine compound chosen from chlorhexidine digluconate and chlorhexidine hydrochloride; and
ii) a polyhexamethylene biguanide salt,
wherein the combination of said 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and said additional compound exhibit synergistic antimicrobial activity.

2. The antimicrobial mixture according to claim 1 , which comprises a poly-hexamethylene biguanide salt.

3. The antimicrobial mixture according to claim 2 , which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and a polyhexamethylene biguanide salt in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/polyhexamethylene biguanide salt weight ratio ranges from 5 to 75.

4. The antimicrobial mixture according to claim 3 , wherein the polyhexamethylene biguanide salt is chosen from hydrochloride, borate, acetate, gluconate, sulfonate, tartrate and citrate.

5. The antimicrobial mixture according to claim 2 , wherein the polyhexamethylene biguanide salt is chosen from hydrochloride, borate, acetate, gluconate, sulfonate, tartrate and citrate.

6. The antimicrobial mixture according to claim 2 , wherein the polyhexamethylene biguanide salt is the hydrochloride salt.

7. The antimicrobial mixture according to claim 1 , wherein the synergistic antimicrobial activity is against at least one of moulds and yeasts.

8. The antimicrobial mixture according to claim 1 , wherein the synergistic antimicrobial activity is against at least one of Aspergillus niger and Candida albicans.

9. The antimicrobial mixture according to claim 1 , which comprises a chlorhexidine compound chosen from chlorhexidine digluconate and chlorhexidine hydrochloride.

10. The antimicrobial mixture according to claim 9 , which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and a chlorhexidine compound chosen from chlorhexidine digluconate and chlorhexidine hydrochloride in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/chlorhexidine compound weight ratio ranges from 2 to 250.

11. The antimicrobial mixture according to claim 10 , wherein the chlorhexidine compound is chlorhexidine digluconate.

12. The antimicrobial mixture according to claim 10 , wherein the chlorhexidine compound is chlorhexidine hydrochloride.

13. The antimicrobial mixture according to claim 9 , wherein the chlorhexidine compound is chlorhexidine digluconate.

14. The antimicrobial mixture according to claim 13 , which has a 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/chlorhexidine digluconate weight ratio ranging from 25 to 150.

15. The antimicrobial mixture according to claim 13 , which has a 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/chlorhexidine digluconate weight ratio ranging from 10 to 75.

16. The antimicrobial mixture according to claim 9 , wherein the chlorhexidine compound is chlorhexidine hydrochloride.

17. The antimicrobial mixture according to claim 16 , which has a 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/chlorhexidine hydrochloride weight ratio ranging from 60 to 250.

18. The antimicrobial mixture according to claim 16 , which has a 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/chlorhexidine hydrochloride weight ratio ranging from 2 to 120.

19. A composition comprising, in a physiologically acceptable medium, an antimicrobial mixture according to claim 1 .

20. The composition according to claim 19 , which comprises at least one additional ingredient chosen from water, oils, polyols containing from 2 to 10 carbon atoms, gelling agents, surfactants, film-forming polymers, dyestuffs, fragrances, fillers, UV-screening agents, plant extracts, cosmetic and dermatological active agents, and salts.

21. The composition according to claim 19 , wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present in a content ranging from 0.01% to 5% by weight relative to the total weight of the composition.

22. A method for the conservation of a composition comprising a physiologically acceptable medium which comprises an antimicrobial mixture according to claim 1 in said composition.

Assignees

• Oreal

Inventors

• Galvan Julien
• Cupferman Sylvie
• Malet Gael

Classifications

• A01N35/02 Primary

  containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals · CPC title

• A61K8/18

  characterised by the composition · CPC title

• A01N47/44

  Guanidine; Derivatives thereof · CPC title