Determining calcium content from spectral CT data

Patent metadata

Field	Value
Publication number	US-10929974-B2
Application number	US-201716301477-A
Country	US
Kind code	B2
Filing date	Jun 14, 2017
Priority date	Jun 15, 2016
Publication date	Feb 23, 2021
Grant date	Feb 23, 2021

Abstract

Present invention relates to devices and methods for determining a calcium content by analyzing cardiac spectral CT data. CT projection data (9), obtainable by scanning a cardiac region of a subject using a spectral CT scanning unit, is modelled (12) by applying a material decomposition algorithm to the projection data to provide a calcium-specific component. Tomographic reconstructions (13) of the projection data, to provide a first 3D image (8), and of the calcium-specific component, to provide a second 3D image (6), are performed. The first 3D image (8) is segmented (14) to provide an image mask (5) corresponding to a cardiovascular structure of interest, a part of the second 3D image (6) is selected (15) based on the image mask (5), and a calcium content is calculated (16) in the cardiovascular structure of interest based on the selected part of the second 3D image (6).

First claim

The invention claimed is:

1. An image data processing device for determining a calcium content by analyzing cardiac spectral CT data, the image data processing device comprising:
a memory that stores a plurality of instructions;
processor circuitry that couples to the memory and that is configured to execute the plurality of instructions to:
receive spectral CT projection data obtained by scanning a cardiac region of a subject using a spectral CT scanning unit;
apply a material decomposition algorithm to said spectral CT projection data such as to provide a calcium-specific component of said spectral CT projection data;
reconstruct said spectral CT projection data such as to provide a first 3D image of said cardiac region and for reconstructing said calcium-specific component of the spectral CT projection data such as to provide a second 3D image representative of calcium content in said cardiac region;
segment said first 3D image such as to provide an image mask corresponding to a cardiovascular structure of interest in said cardiac region, wherein both of the segmented first 3D image and the second 3D image are derived from the same spectral CT projection data;
select a part of said second 3D image based on said image mask; and
calculate a calcium content in said cardiovascular structure of interest based on said selected part of the second 3D image.

2. The image data processing device of claim 1 , wherein the processor circuitry is further configured to provide the image mask corresponding to a coronary artery or part thereof in said cardiac region.

3. The image data processing device of claim 1 , wherein the processor circuitry is further configured to select a first set of voxels of said second 3D image that form said cardiovascular structure of interest, and wherein the processor circuitry is further configured to integrate an amount of calcium represented by said selected voxels such as to calculate the calcium content in the cardiovascular structure of interest.

4. The image data processing device of claim 1 , wherein the processor circuitry is further configured to select a second set of voxels of said second 3D image that is the set complement of the voxels that form said cardiovascular structure of interest,
wherein the processor circuitry is further configured to project the second set of voxels to generate simulated projection data corresponding to the same projections as said spectral CT projection data, and
wherein the processor circuitry is further configured to subtract said simulated projection data from said calcium-specific component of the spectral CT projection data to obtain subtracted projection data representative of calcium specific attenuation in specifically the cardiovascular structure of interest.

5. The image data processing device of claim 4 , wherein the processor circuitry is further configured to integrate an amount of calcium represented by each projection image comprised in said subtracted projection data to calculate a plurality of calcium content measurements.

6. The image data processing device of claim 5 , wherein the processor circuitry is further configured to re-bin said subtracted projection data into projection images corresponding to parallel geometries prior to said integrating of the amount of calcium represented by each projection image.

7. The image data processing device of claim 5 , wherein the processor circuitry is further configured to calculate a measure of statistical central tendency of said plurality of calcium content measurements.

8. The image data processing device of claim 5 , wherein the processor circuitry is further configured to calculate a measure of statistical dispersion and/or a statistical confidence interval of said plurality of calcium content measurements.

9. The image data processing device of claim 1 , wherein the processor circuitry is further configured to partition the spectral CT projection data into said calcium-specific component and at least a first further component indicative of attenuation specific to soft tissue and/or water.

10. The image data processing device of claim 9 , wherein the processor circuitry is further configured to partition the spectral CT projection data into said calcium-specific component, said first further component and at least a second further component indicative of attenuation specific to a predetermined contrast agent.

11. The image data processing device of claim 1 , wherein the processor circuitry is further configured to implement a forward model for detected photon counts represented by said spectral CT projection data, and to apply a maximum likelihood estimation method to determine a material length along each projection path for each modelled material, the modelled materials comprising at least calcium.

12. A workstation comprising the image data processing device of claim 1 .

13. An imaging system comprising the image data processing device of claim 1 , and a spectral CT scanner generating said spectral CT projection data when scanning said cardiac region and supplying this spectral CT projection data to said data input.

14. A method for determining a calcium content by analyzing cardiac spectral CT data, the method comprising:
obtaining spectral CT projection data corresponding to a scanned cardiac region of a subject;
applying a material decomposition algorithm to said spectral CT projection data such as to provide a calcium-specific component of said spectral CT projection data;
reconstructing said spectral CT projection data such as to provide a first 3D image of said cardiac region;
reconstructing said calcium-specific component of the spectral CT projection data such as to provide a second 3D image representative of calcium content in said cardiac region;
segmenting said first 3D image such as to provide an image mask corresponding to a cardiovascular structure of interest in said cardiac region, wherein both of the segmented first 3D image and the second 3D image are derived from the same spectral CT projection data;
selecting a part of said second 3D image based on said image mask; and
calculating a calcium content in said cardiovascular structure of interest based on said selected part of the second 3D image.

15. A non-transitory computer-readable medium having computer readable program code for calculating, when executed by a computer, a calcium content by analyzing cardiac spectral CT data, in which said calculation comprises performing a method for determining a calcium content by analyzing cardiac spectral CT data, the method comprising:
obtaining spectral CT projection data corresponding to a scanned cardiac region of a subject;
applying a material decomposition algorithm to said spectral CT projection data such as to provide a calcium-specific component of said spectral CT projection data;
reconstructing said spectral CT projection data such as to provide a first 3D image of said cardiac region;
reconstructing said calcium-specific component of the spectral CT projection data such as to provide a second 3D image representative of calcium content in said cardiac region;
segmenting said first 3D image such as to provide an image mask corresponding to a cardiovascular structure of interest in said cardiac region, wherein both of the segmented first 3D image and the second 3D image are derived from the same spectral CT projection data;
selecting a part of said second 3D image based on said image mask; and
calculating a calcium content in said cardiovascular structure of interest based on said selected part of the second 3D image.

16. The image d

Assignees

• Koninklijke Philips Nv

Inventors

• Schaefer Dirk
• Daerr Heiner
• Koehler Thomas
• Roessl Ewald

Classifications

• G06T12/10

  Image preprocessing, e.g. calibration, positioning of sources or scatter correction · CPC title

• G06T2207/30048

  Heart; Cardiac · CPC title

• G06T2211/408

  Dual energy · CPC title

• G06T7/0012 Primary

  Biomedical image inspection · CPC title

• G06T2207/30101

  Blood vessel; Artery; Vein; Vascular · CPC title