Liver-receptor imaging injection, dispensing method and pharmaceutical composition thereof
US-9040017-B2 · May 26, 2015 · US
Hexa-lactoside-triazanonane triacetic acid (NOTA) derivative, method for radiolabeling hexa-lactoside positron emission tomography (PET) imaging agent for liver receptor with Ga-68, and hexa-lactoside PET imaging agent for liver receptor
US10925981B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10925981-B2 |
| Application number | US-201816200833-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 27, 2018 |
| Priority date | May 9, 2018 |
| Publication date | Feb 23, 2021 |
| Grant date | Feb 23, 2021 |
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Abstract
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The present invention provides a hexa-lactoside-triazanonane triacetic acid (NOTA) derivative, a method for radiolabeling a hexa-lactoside positron emission tomography (PET) imaging agent for a liver receptor with Ga-68, and a hexa-lactoside PET imaging agent for a liver receptor. The hexa-lactoside-NOTA derivative is a conjugate of six chains of lactose with NOTA obtained by conjugating hexa-lactoside to a chelating agent p-thiocyanate-benzyl-triazanonane diacetic acid-glutamic acid in the presence of triethyl amine/dimethyl formamide as a solvent. The radiolabeling method comprises labeling with Ga-68 at room temperature. According to the present invention, the labeling effect is stable, the labeling efficiency of the labeled product is greater than 95%, the labeled product is highly stable and the radiochemical purity is still greater than 90% after 4 hours.
First claim
Opening claim text (preview).
What is claimed is: 1. A hexa-lactoside-triazanonane triacetic acid (NOTA) derivative, having a structure of: 2. A hexa-lactoside positron emission tomography (PET) imaging agent for a liver receptor, having a structure of: 3. The imaging agent according to claim 2 , which is prepared by the steps of: reacting 3-valent Ga-68 and a triazanonane triacetic acid (NOTA) conjugate of six chains of lactose with sodium acetate buffer in a freeze drying ampoule at room temperature.
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Classifications
Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids · CPC title
Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12 (esters with inorganic acids C07H11/00) · CPC title
Isotopically modified compounds, e.g. labelled · CPC title
- A61K51/065Primary
conjugates with carriers being macromolecules · CPC title
Acyclic or carbocyclic radicals, substituted by hetero rings · CPC title
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- What does patent US10925981B2 cover?
- The present invention provides a hexa-lactoside-triazanonane triacetic acid (NOTA) derivative, a method for radiolabeling a hexa-lactoside positron emission tomography (PET) imaging agent for a liver receptor with Ga-68, and a hexa-lactoside PET imaging agent for a liver receptor. The hexa-lactoside-NOTA derivative is a conjugate of six chains of lactose with NOTA obtained by conjugating hexa-l…
- Who is the assignee on this patent?
- Iner Aec Executive Yuan
- What technology area does this patent fall under?
- Primary CPC classification A61K51/065. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).