Peroxide dispersions

Patent metadata

Field	Value
Publication number	US-10925302-B2
Application number	US-201715825377-A
Country	US
Kind code	B2
Filing date	Nov 29, 2017
Priority date	Jun 15, 2012
Publication date	Feb 23, 2021
Grant date	Feb 23, 2021

Abstract

The viscosity of aqueous dispersions of normally solid organic peroxides may be advantageously lowered through the use of surfactants which are polyglyceryl esters of C6-C12 fatty acids. The reduction in viscosity facilitates milling the peroxides to reduce particle size and also provides dispersions of small particle size peroxides which may be readily poured or pumped. The aqueous dispersions are useful as components of pharmaceutical, personal care, and cleaning products and the like and are effective decolorizing agents for food products, industrial products and the like.

First claim

What is claimed is:

1. A composition comprising:
a) an aqueous pumpable, pourable, or sprayable dispersion having a viscosity between 800 and 2000 centipoise, based on said dispersion, and which is shear thinning and sufficiently fluid such that it is capable of being poured without subjection to stirring, comprised of:
i) about 35% by weight or more, based on said dispersion, of water insoluble, solid benzoyl peroxide having an average particle size of less than 10 μm,
ii) 0.1 weight % to 2 weight % surfactant, based on said dispersion, which is a polyglyceryl ester of one or more C6-C12 fatty acids selected from the group consisting of octanoic acid, decanoic acid, and mixtures thereof, wherein the surfactant has an HLB value of 12 to 18;

b) optionally, at least one additional pharmaceutically acceptable component, and
c) optionally, one or more excipients.

2. The composition of claim 1 , wherein the at least one pharmaceutically acceptable component is selected from the group consisting of antibacterial agents, antimicrobial agents, and bleach activators.

3. The composition of claim 1 comprising at least one pharmaceutically acceptable component selected from the group consisting of pharmaceutically active ingredients.

4. The composition of claim 1 comprising at least one excipient selected from the group consisting of fillers, carriers, surfactants, pigments, stabilizers, rheology control agents, gelling agents, flavorants, remineralizers, and emollients.

5. The composition of claim 1 comprising at least one additional pharmaceutically acceptable component that is a pharmaceutically active ingredient, at least one excipient, and optionally water.

6. The composition of claim 1 , wherein the polyglyceryl ester of one or more C6-C12 fatty acids contains a polyglycerol moiety having 8 to 12 glycerol repeating units on average.

7. The composition of claim 1 , wherein the surfactant is based on a polyglyceryl having hydroxyl groups with from about 25% to about 60% of the hydroxyl groups of the polyglyceryl being esterified.

8. The composition of claim 1 , wherein the surfactant is a polyglyceryl-10 caprylate/caprate.

9. The composition of claim 1 , wherein the surfactant is a pharmaceutically acceptable surfactant.

10. The composition of claim 1 , wherein the solid benzoyl peroxide has an average particle size of less than 5 μm.

11. The composition of claim 1 , wherein the surfactant has structure (I):
R 1 —[CH 2 —CH(OR 2 )—CH 2 O] n —R 3 wherein the average value of n is from about 6 to about 14 and R 1 , R 2 and R 3 are each independently a C8 or C10 fatty acid moiety or hydrogen, provided that at least one of R 1 , R 2 or R 3 is a C8 or C10 fatty acid moiety.

12. The composition of claim 1 , wherein the composition is an anti-acne composition.

13. The composition of claim 1 , wherein the composition is a teeth whitening composition.

14. The composition of claim 1 , wherein the composition is a hair coloring or hair bleaching composition.

15. The composition of claim 1 , wherein the composition is a paste, lotion, soap, gel or cream.

16. The composition of claim 1 , wherein the aqueous dispersion remains fluid during milling and stably dispersed thereafter, and which has a viscosity between 800 and 2000 centipoise and is shear thinning, comprises:
about 37 to about 42 weight %, based on said dispersion, benzoyl peroxide having an average particle size of less than 5 μm;
about 53 to about 62 weight %, based on said dispersion, water;
about 0.2 to about 2 weight %, based on said dispersion, gelling agent;
about 0.1 to about 2 weight % polyglyceryl ester, based on said dispersion, which contains a polyglycerol moiety having 8 to 12 glycerol repeating units on average which is partially esterified with a mixture of octanoic acid and decanoic acid and has an HLB value of 12-18;
about 0.01 to about 0.05 weight %, based on said dispersion, crosslinking agent; and
about 0.2 to about 1 weight %, based on said dispersion, base.

17. A composition derived from a process comprising the step of combining:
a) an aqueous pumpable, pourable, or sprayable dispersion having a viscosity between 800 and 2000 centipoise and which is shear thinning and sufficiently fluid such that it is capable of being poured without subjection to stirring, comprised of:
i) about 35% by weight or more, based on said dispersion, of water insoluble, solid benzoyl peroxide having an average particle size of less than 10 μm,
ii) 0.1 weight % to 2 weight % surfactant, based on said dispersion, which is a polyglyceryl ester of one or more C6-C12 fatty acids selected from the group consisting of octanoic acid, decanoic acid, and mixtures thereof, wherein the surfactant has an HLB value of 12 to 18;
with either

b) at least one additional pharmaceutically acceptable component,
or

c) one or more excipients.

Assignees

• Arkema Inc

Inventors

• Kozel Thomas H
• Gravelle Joseph M
• Belford Timothy
• Salvador Tomas
• Despotopoulou Marina

Classifications

• A61K9/145 Primary

  with organic compounds · CPC title

• A23L5/49 Primary

  Removing colour by chemical reaction, e.g. bleaching · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• C11D3/3947

  Liquid compositions · CPC title

• A61Q5/08

  Preparations for bleaching the hair · CPC title