Graphene bio-device for electrotherapy

Patent metadata

Field	Value
Publication number	US-10918856-B2
Application number	US-201816030863-A
Country	US
Kind code	B2
Filing date	Jul 10, 2018
Priority date	Jan 22, 2018
Publication date	Feb 16, 2021
Grant date	Feb 16, 2021

Abstract

A graphene bio-device for electrotherapy, includes: a flexible substrate; An electrode made of graphene on the flexible substrate; and an insulation layer on the graphene electrode; wherein the graphene bio-device comprises electrodes for ground, reference, recording and stimulation, wherein the graphene bio-device is measured corticography with low noise and alleviated seizure signals successfully by imposing electrical stimulation.

First claim

What is claimed is:

1. A neurostimulating apparatus, consisting of:
a graphene bio-device consisting of:
a flexible substrate which is PMMA (polymethylmethacrylate);
doped four-layer graphene electrodes on the flexible substrate forming an electrode array having 30 channels for recording and electrotherapy; and
an insulation layer on the doped four-layer graphene electrodes which comprise ground electrodes, reference electrodes, recording electrodes and stimulation electrodes;

a neurostimulator generating sinusoidal high frequency stimulation signals and enabling the graphen bio-device to provide neurostimulating signals to a target, wherein the sinusoidal high frequency stimulation signals include an amplitude of 1V, a frequency of 100 Hz, and a duration of 30 sec;
an amplifier intensifying brain signals from the graphene bio-device; and
an interface transmitting the amplified brain signals to a user terminal,
wherein the graphene bio-device, the neurostimulator, the amplifier, and the interface are connected to each other by a lead.

2. A method for detecting signals from a mammalian brain or a mammalian tissue and electrical stimulation to the brain or the tissue using the graphene bio-device claim 1 .

3. The method of claim 2 , wherein the electrical stimulation is sinusoidal high frequency stimulation (sHFS).

4. The neurostimulating apparatus of claim 1 , wherein the insulation layer is OCR (optical clean resin), OCA (optical clean adhesive) or SU-8.

5. The neurostimulating apparatus of claim 1 , wherein the doped four-layer graphene electrodes layers have a specific capacitance of 326.7 F/g.

6. The neurostimulating apparatus of claim 1 , wherein the graphene bio-device is placed in somatosensory area or motor cortical area.

Assignees

• Univ Incheon Ind Acad Coop
• Univ Yonsei Iacf
• Gbrain Inc

Inventors

• Yang Sunggu
• Ahn Jong-Hyun
• Kim Jejung
• Lee Wonho
• Kang Minpyo

Classifications

• A61B5/686

  Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence) · CPC title

• A61B2562/125

  characterised by the manufacture of electrodes · CPC title

• A61N1/06

  for high-frequency therapy · CPC title

• A61N1/0531 Primary

  Brain cortex electrodes · CPC title

• A61B5/4064

  Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369) · CPC title