Combination containing SGC stimulators and mineralocorticoid receptor antagonists

Patent metadata

Field	Value
Publication number	US-10918639-B2
Application number	US-201716340810-A
Country	US
Kind code	B2
Filing date	Oct 5, 2017
Priority date	Oct 11, 2016
Publication date	Feb 16, 2021
Grant date	Feb 16, 2021

Abstract

The present invention relates to the combination of stimulators of soluble guanylate cyclase (sGC stimulators) with mineralocorticoid receptor antagonists (MR antagonists) and to the use of the combination for the treatment and/or prophylaxis of cardiac and cardiovascular disorders, of renal and cardiorenal disorders, of pulmonary and cardiopulmonary disorders and also for the treatment and/or prophylaxis of fibrotic disorders.

First claim

The invention claimed is:

1. A combination comprising (methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate) of the formula (X)

and (S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (IV)

2. A medicament comprising the combination of claim 1 in combination with an inert, non-toxic, pharmaceutically suitable auxiliary.

3. A medicament comprising the combination of claim 1 in combination with one or more further active compounds selected from the group consisting of ACE inhibitors, angiotensin receptor blockers, combinations of angiotensin receptor blockers and NEP inhibitors (ARNIs), antidiabetics, betablockers, acetylsalicylic acid, diuretics, I f channel blockers (ivabradin), calcium antagonists, statins, digitalis (digoxin) derivatives, calcium sensitizers, nitrates and antithrombotics.

4. A method for the treatment of a cardiac or cardiovascular disorder that is heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, atrial fibrillation, stroke or atherosclerosis, a renal or cardiorenal disorder that is chronic kidney failure or diabetic nephropathy, or a lung or cardiopulmonary disorder that is pulmonary hypertension in humans and animals comprising administering a therapeutically effective amount of a medicament according to claim 2 to a human or animal in need thereof.

5. The method of claim 4 , wherein 10 to 40 mg of (S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (IV) is administered.

6. A kit comprising a pharmaceutical composition comprising finerenone and the compound of the formula (X)

7. A method for the treatment of a cardiac or cardiovascular disorder that is heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, atrial fibrillation, stroke or atherosclerosis, a renal or cardiorenal disorder that is chronic kidney failure or diabetic nephropathy, or a lung or cardiopulmonary disorder that is pulmonary hypertension comprising administering a therapeutically effective amount of a combination of an sGC stimulator and a non-steroidal MR antagonist to a human or animal in need thereof, wherein the sGC stimulator is methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (X)

and the non-steroidal MR antagonist is (S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (IV)

8. The method of claim 7 , wherein the sGC stimulator and the non-steroidal MR antagonist are administered sequentially.

9. The method of claim 7 , wherein the sGC stimulator and the non-steroidal MR antagonist are administered in two separate unit dosage forms.

10. The method of claim 7 , wherein 10 to 40 mg of (S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (IV) is administered.

11. The method of claim 7 , wherein the sGC stimulator and the non-steroidal MR antagonist are administered simultaneously.

12. The method of claim 7 , wherein the method is for treatment of chronic kidney failure or diabetic nephropathy.

13. The method of claim 7 , wherein the method is for treatment of heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, atrial fibrillation, stroke or atherosclerosis.

14. The method of claim 13 , wherein the method is for treatment of heart failure with preserved ejection fraction or heart failure with reduced ejection fraction.

15. The method of claim 7 , wherein the method is for treatment of pulmonary hypertension.

16. The method of claim 7 , further comprising administering a therapeutically effective amount of one or more further active compounds selected from the group consisting of ACE inhibitors, angiotensin receptor blockers, combinations of angiotensin receptor blockers and NEP inhibitors, antidiabetics, betablockers, acetylsalicylic acid, diuretics, I f channel blockers, calcium antagonists, statins, digitalis derivatives, calcium sensitizers, nitrates and antithrombotics.

17. The method of claim 7 , wherein 1.25 to 10 mg of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyri din-3-yl]pyrimidin-5-yl}carbamate of the formula (X) is administered.

18. The method of claim 10 , wherein 1.25 to 10 mg of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (X) is administered.

19. The method of claim 7 , wherein 1 to 15 mg of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (X) and 2.5 to 50 mg of (S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (IV) is administered.

Assignees

• Bayer Pharma AG

Inventors

• Kolkhof Peter
• Sandner Peter

Classifications

• A61K31/167 Primary

  having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61K31/4375

  the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine · CPC title

• A61K31/506 Primary

  not condensed and containing further heterocyclic rings · CPC title